Abstract
In experimental models of brain injury of the ischemia-reperfusion type, there is a period of time in which the formation of oxidative damage exceeds its repair. Simultaneously, the expression of immediate early genes is induced to activate the expression of late effector genes. Drugs that reduce the need to repair during this transient period of time also attenuate neuronal death after brain injury. An example discussed in this review is the activator protein-1 (AP-1), the product of the c-fos gene and other immediate early genes. What is the effect of a delayed expression of these genes in relationship to the process of cell death? This short period presents a window of opportunity to study the effects of oxidative damage on gene expression in the brain and specific deficiencies in gene repair that have been associated with particular neurological disorders.
Keywords: Oxidative stress, Immediate early genes, Neurodegenerative diseases, 8-oxo-guanosine glycosylase/AP lyase, Fos/AP-1
Current Topics in Medicinal Chemistry
Title: DNA Damage and Repair in the Brain After Cerebral Ischemia
Volume: 1 Issue: 6
Author(s): Philip K. Liu
Affiliation:
Keywords: Oxidative stress, Immediate early genes, Neurodegenerative diseases, 8-oxo-guanosine glycosylase/AP lyase, Fos/AP-1
Abstract: In experimental models of brain injury of the ischemia-reperfusion type, there is a period of time in which the formation of oxidative damage exceeds its repair. Simultaneously, the expression of immediate early genes is induced to activate the expression of late effector genes. Drugs that reduce the need to repair during this transient period of time also attenuate neuronal death after brain injury. An example discussed in this review is the activator protein-1 (AP-1), the product of the c-fos gene and other immediate early genes. What is the effect of a delayed expression of these genes in relationship to the process of cell death? This short period presents a window of opportunity to study the effects of oxidative damage on gene expression in the brain and specific deficiencies in gene repair that have been associated with particular neurological disorders.
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Cite this article as:
Philip K. Liu , DNA Damage and Repair in the Brain After Cerebral Ischemia, Current Topics in Medicinal Chemistry 2001; 1 (6) . https://dx.doi.org/10.2174/1568026013394688
DOI https://dx.doi.org/10.2174/1568026013394688 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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