The Relationship Between the Py3 Amino Acid in the Phosphopeptide Ligands and the Specificity for Various Sh2 Domains

Title: The Relationship Between the Py3 Amino Acid in the Phosphopeptide Ligands and the Specificity for Various Sh2 Domains

Volume: 11 Issue: 6

Author(s): Keun-Hyeung Lee and See-Hyoung Park

Affiliation:

Keywords: sh2 domain, specificity, phosphopeptide, ligand, lck, src, fyn

Abstract: After consideration of the tertiary structure of the pY+3 binding pocket in SH2 domains, isoleucine of Ac-pYEEIE was replaced with various unnatural aliphatic amino acids and the binding affinities for Lck, Src, and Fyn SH2 domains were measured. We determined the characteristics of the amino acid at the pY+3 position in the phosphopeptide ligands for the specificity for the SH2 domains.

Cite this article as:

Lee Keun-Hyeung and Park See-Hyoung, The Relationship Between the Py3 Amino Acid in the Phosphopeptide Ligands and the Specificity for Various Sh2 Domains, Protein & Peptide Letters 2004; 11 (6) . https://dx.doi.org/10.2174/0929866043406337