Abstract
The isolation and biological activity of carbazole alkaloids is summarized. Recent developments of novel methodologies for the synthesis of carbazole alkaloids are described. The focus is on syntheses using the oxidative coupling of arylamines with either arenes, cyclohexadienes, or cyclohexene mediated or catalyzed by palladium, iron, or molybdenum. The implementation of these annulations in total syntheses provides highly convergent routes to biologically active carbazole alkaloids. Advantages, scope, and limitations of the different synthetic methods are discussed.
Keywords: carbazole alkaloids, cyclohexene, cyclohexadienes, arylamines
Current Organic Synthesis
Title: Transition Metal Complexes in Organic Synthesis, Part 70. Synthesis of Biologically Active Carbazole Alkaloids Using Organometallic Chemistry
Volume: 1 Issue: 4
Author(s): Hans-Joachim Knolker
Affiliation:
Keywords: carbazole alkaloids, cyclohexene, cyclohexadienes, arylamines
Abstract: The isolation and biological activity of carbazole alkaloids is summarized. Recent developments of novel methodologies for the synthesis of carbazole alkaloids are described. The focus is on syntheses using the oxidative coupling of arylamines with either arenes, cyclohexadienes, or cyclohexene mediated or catalyzed by palladium, iron, or molybdenum. The implementation of these annulations in total syntheses provides highly convergent routes to biologically active carbazole alkaloids. Advantages, scope, and limitations of the different synthetic methods are discussed.
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Cite this article as:
Knolker Hans-Joachim, Transition Metal Complexes in Organic Synthesis, Part 70. Synthesis of Biologically Active Carbazole Alkaloids Using Organometallic Chemistry, Current Organic Synthesis 2004; 1 (4) . https://dx.doi.org/10.2174/1570179043366594
DOI https://dx.doi.org/10.2174/1570179043366594 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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