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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

α-Synuclein and the Pathogenesis of Parkinsons Disease

Author(s): Francis L. Martin, Sally J.M. Williamson, Katerina E. Paleologou, David Allsop and Omar M.A. El-Agnaf

Volume 11, Issue 3, 2004

Page: [229 - 237] Pages: 9

DOI: 10.2174/0929866043407138

Price: $65

Abstract

Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinsons disease (PD) patients. Intracellular aggregation of α-synuclein (α-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.

Keywords: dna single-strand breaks, comet assay, reactive oxygen species, environmental causation


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