Differential Desensitization of Somatostatin Receptor Subtypes in AtT-20 Cells

Title: Differential Desensitization of Somatostatin Receptor Subtypes in AtT-20 Cells

Volume: 11 Issue: 2

Author(s): Fredric C. Mazza and Allan D. Blake

Affiliation:

Keywords: Somatostatin,, nonpeptidyl agonists,, receptor subtype,, desensitization,

Abstract: Nonpeptidyl agonists for the somatostatin (SRIF) receptor family have been developed. We have studied the desensitization effects for two of these agonists upon SRIF receptor function in AtT-20 cells, a neuroendocrine tumor cell, which endogenously expresses two distinct SRIF receptor, subtypes. We observe that SRIF and the nonpeptidyl, subtype selective agonists, differentially regulate SRIF receptor subtypes in the AtT-20 cell.

Cite this article as:

Mazza C. Fredric and Blake D. Allan, Differential Desensitization of Somatostatin Receptor Subtypes in AtT-20 Cells, Protein & Peptide Letters 2004; 11 (2) . https://dx.doi.org/10.2174/0929866043478239