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Abstract
Nonpeptidyl agonists for the somatostatin (SRIF) receptor family have been developed. We have studied the desensitization effects for two of these agonists upon SRIF receptor function in AtT-20 cells, a neuroendocrine tumor cell, which endogenously expresses two distinct SRIF receptor, subtypes. We observe that SRIF and the nonpeptidyl, subtype selective agonists, differentially regulate SRIF receptor subtypes in the AtT-20 cell.
Keywords: Somatostatin,, nonpeptidyl agonists,, receptor subtype,, desensitization,
Protein & Peptide Letters
Title: Differential Desensitization of Somatostatin Receptor Subtypes in AtT-20 Cells
Volume: 11 Issue: 2
Author(s): Fredric C. Mazza and Allan D. Blake
Affiliation:
Keywords: Somatostatin,, nonpeptidyl agonists,, receptor subtype,, desensitization,
Abstract: Nonpeptidyl agonists for the somatostatin (SRIF) receptor family have been developed. We have studied the desensitization effects for two of these agonists upon SRIF receptor function in AtT-20 cells, a neuroendocrine tumor cell, which endogenously expresses two distinct SRIF receptor, subtypes. We observe that SRIF and the nonpeptidyl, subtype selective agonists, differentially regulate SRIF receptor subtypes in the AtT-20 cell.
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Cite this article as:
Mazza C. Fredric and Blake D. Allan, Differential Desensitization of Somatostatin Receptor Subtypes in AtT-20 Cells, Protein & Peptide Letters 2004; 11 (2) . https://dx.doi.org/10.2174/0929866043478239
DOI https://dx.doi.org/10.2174/0929866043478239 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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