Abstract
Folate, a B vitamin found almost ubiquitously in foods, is required for de novo nucleotide synthesis and methylation reactions in our body. A shortage of folate can lead to macrocytic anemia, however, extra folic acid, the synthetic form of folate, is considered to be a modern day panacea for a variety of diseases, specifically vascular disease. This review summarizes the evidence from randomized controlled trials and illustrates the weak foundation on which health claims regarding the possible beneficial effect of extra folic acid for vascular disease are based. It is prudent for public health policy makers to await trials--the conventional golden standard by which to test causality--before deciding on folic acid fortification for the general population.
Keywords: folic acid, b vitamin, natural foods, antioxidant, amino acid
Current Nutrition & Food Science
Title: Let Them Eat Cake
Volume: 1 Issue: 1
Author(s): Jane Durga and Petra Verhoef
Affiliation:
Keywords: folic acid, b vitamin, natural foods, antioxidant, amino acid
Abstract: Folate, a B vitamin found almost ubiquitously in foods, is required for de novo nucleotide synthesis and methylation reactions in our body. A shortage of folate can lead to macrocytic anemia, however, extra folic acid, the synthetic form of folate, is considered to be a modern day panacea for a variety of diseases, specifically vascular disease. This review summarizes the evidence from randomized controlled trials and illustrates the weak foundation on which health claims regarding the possible beneficial effect of extra folic acid for vascular disease are based. It is prudent for public health policy makers to await trials--the conventional golden standard by which to test causality--before deciding on folic acid fortification for the general population.
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Cite this article as:
Durga Jane and Verhoef Petra, Let Them Eat Cake, Current Nutrition & Food Science 2005; 1 (1) . https://dx.doi.org/10.2174/1573401052953221
DOI https://dx.doi.org/10.2174/1573401052953221 |
Print ISSN 1573-4013 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3881 |
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