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Abstract
Comprehensive analysis of the metabolome can contribute to mechanism of action studies for small molecules discovered in phenotypic screens. Examples are presented in this overview of the rapidly developing field of “metabolic profiling.” These examples include the use of NMR in gene function analysis, GC-based studies on the identification of metabolic pathways affected by PPAR-γ agonists, applications of Fourier-transform MS and the use of stable isotope-based metabolic profiling (SIDMAP) to investigate metabolic adaptive changes induced by effective anticancer agents.
Keywords: chemical genetics, reverse pharmacology, metabolic profiling, metabolic fingerprinting, metabonomics, metabolomics, sidmap
Mini-Reviews in Medicinal Chemistry
Title: Medicinal Chemistry, Metabolic Profiling and Drug Target Discovery: A Role for Metabolic Profiling in Reverse Pharmacology and Chemical Genetics
Volume: 5 Issue: 1
Author(s): George G. Harrigan, Daniel J. Brackett and Laszlo G. Boros
Affiliation:
Keywords: chemical genetics, reverse pharmacology, metabolic profiling, metabolic fingerprinting, metabonomics, metabolomics, sidmap
Abstract: Comprehensive analysis of the metabolome can contribute to mechanism of action studies for small molecules discovered in phenotypic screens. Examples are presented in this overview of the rapidly developing field of “metabolic profiling.” These examples include the use of NMR in gene function analysis, GC-based studies on the identification of metabolic pathways affected by PPAR-γ agonists, applications of Fourier-transform MS and the use of stable isotope-based metabolic profiling (SIDMAP) to investigate metabolic adaptive changes induced by effective anticancer agents.
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Cite this article as:
Harrigan G. George, Brackett J. Daniel and Boros G. Laszlo, Medicinal Chemistry, Metabolic Profiling and Drug Target Discovery: A Role for Metabolic Profiling in Reverse Pharmacology and Chemical Genetics, Mini-Reviews in Medicinal Chemistry 2005; 5 (1) . https://dx.doi.org/10.2174/1389557053402800
DOI https://dx.doi.org/10.2174/1389557053402800 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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