Abstract
A series of new peptidomimetics based on the tripeptide sequence Z-Leu-Phe-Gln-OH were synthesized, with ten of these including the α-nitrogen atom of the N-terminal amino acid incorporated into the pyrrole cycle. The synthesized compounds were tested for antiviral activity by agar-diffusion plaque inhibition test against Coxsackievirus B1 replication in FL cell. Four of the products were observed to possess an antiviral activity, which was proven to be significant for one product. N- terminal pyrrole moiety and C-terminal free carboxyl function are available in all active compounds. On the other hand, their corresponding -OBzl and -OBut esters are inactive.
Keywords: Antipicornaviral compounds, pyrroles, peptidomimetics, 3C inhibitors, Coxsackievirus, SPPS
Protein & Peptide Letters
Title: Design, Synthesis and Biological Evaluation of Antipicornaviral Pyrrole-Containing Peptidomimetics
Volume: 14 Issue: 9
Author(s): I. Minchev, S. Vladimirova, L. Vezenkov, A. Bijev, V. Moussis, L. Nikolaeva-Glomb, V. Tsikaris, M. Czeuz and A. Galabov
Affiliation:
Keywords: Antipicornaviral compounds, pyrroles, peptidomimetics, 3C inhibitors, Coxsackievirus, SPPS
Abstract: A series of new peptidomimetics based on the tripeptide sequence Z-Leu-Phe-Gln-OH were synthesized, with ten of these including the α-nitrogen atom of the N-terminal amino acid incorporated into the pyrrole cycle. The synthesized compounds were tested for antiviral activity by agar-diffusion plaque inhibition test against Coxsackievirus B1 replication in FL cell. Four of the products were observed to possess an antiviral activity, which was proven to be significant for one product. N- terminal pyrrole moiety and C-terminal free carboxyl function are available in all active compounds. On the other hand, their corresponding -OBzl and -OBut esters are inactive.
Export Options
About this article
Cite this article as:
Minchev I., Vladimirova S., Vezenkov L., Bijev A., Moussis V., Nikolaeva-Glomb L., Tsikaris V., Czeuz M. and Galabov A., Design, Synthesis and Biological Evaluation of Antipicornaviral Pyrrole-Containing Peptidomimetics, Protein & Peptide Letters 2007; 14 (9) . https://dx.doi.org/10.2174/092986607782110220
DOI https://dx.doi.org/10.2174/092986607782110220 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Myocardial Contrast Echocardiography: Role in Clinical Cardiology
Current Vascular Pharmacology Current Antithrombotic Therapy: Beyond Coronary Artery Disease
Current Pharmaceutical Design Medicinal Plants and Bioactive Compounds for Diabetes Management: Important Advances in Drug Discovery
Current Pharmaceutical Design Incremental Value of Two Dimensional Speckle Tracking Echocardiography in the Functional Assessment and Characterization of Subclinical Left Ventricular Dysfunction
Current Cardiology Reviews Functional Variants of the Interleukin-23 Receptor Gene in Non-Gastrointestinal Autoimmune Diseases
Current Medicinal Chemistry MicroRNAs in the Management of Heart Failure
Current Medicinal Chemistry Unfolding Cardiac Amyloidosis –From Pathophysiology to Cure
Current Medicinal Chemistry MicroRNAs: Novel Diagnostic and Prognostic Biomarkers in Atherosclerosis
Current Topics in Medicinal Chemistry Dynorphins in Development and Disease: Implications for Cardiovascular Disease
Current Molecular Medicine Oxidative Stress During Myocardial Ischaemia and Heart Failure
Current Pharmaceutical Design Atrial Fibrillation with a Focus on Oral Antiarrhythmic Therapy
Current Drug Therapy Electrocardiographic and Cardiac Autonomic Indices - Implications of Sex-Specific Risk Stratification in Women After Acute Myocardial Infarction
Current Pharmaceutical Design Artificial Intelligence for Epigenetics: Towards Personalized Medicine
Current Medicinal Chemistry Glucagon-Like Peptide 1 and the Cardiovascular System
Current Diabetes Reviews Thienopyridines in Percutaneous Coronary Interventions: Standard Procedures and High Risk Subsets
Current Pharmaceutical Design Inhibition of Sphingomyelin Hydrolysis: Targeting the Lipid Mediator Ceramide as a Key Regulator of Cellular Fate
Current Medicinal Chemistry Research Advancements in Porcine Derived Mesenchymal Stem Cells
Current Stem Cell Research & Therapy Past, Present and Future Therapeutics for Cerebellar Ataxias
Current Neuropharmacology Exercise as Treatment for Neuropathy in the Setting of Diabetes and Prediabetic Metabolic Syndrome: A Review of Animal Models and Human Trials
Current Diabetes Reviews Endothelial Cell Senescence and Inflammaging: MicroRNAs as Biomarkers and Innovative Therapeutic Tools
Current Drug Targets