Abstract
The last 10 years have seen resurgent industry activity in discovery and development of new drugs for the treatment of tuberculosis (TB), a growing widespread and devastating (more than 2 million deaths annually) bacterial infection that is of increasing concern in developing and developed nations alike. This review describes drugs currently being evaluated in the clinic for treatment of uncomplicated and drug resistant pulmonary TB, and updates the literature on 5 new drugs that entered clinical trials in the last 4 years.
Keywords: drug resistant M. tuberculosis, HIV therapy, BACTEC growth assay, fluoroquinolone, PA-824
Medicinal Chemistry
Title: In Search of New Cures for Tuberculosis
Volume: 3 Issue: 3
Author(s): Marina Protopopova, Elena Bogatcheva, Boris Nikonenko, Sam Hundert, Leo Einck and Carol A. Nacy
Affiliation:
Keywords: drug resistant M. tuberculosis, HIV therapy, BACTEC growth assay, fluoroquinolone, PA-824
Abstract: The last 10 years have seen resurgent industry activity in discovery and development of new drugs for the treatment of tuberculosis (TB), a growing widespread and devastating (more than 2 million deaths annually) bacterial infection that is of increasing concern in developing and developed nations alike. This review describes drugs currently being evaluated in the clinic for treatment of uncomplicated and drug resistant pulmonary TB, and updates the literature on 5 new drugs that entered clinical trials in the last 4 years.
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Cite this article as:
Protopopova Marina, Bogatcheva Elena, Nikonenko Boris, Hundert Sam, Einck Leo and Nacy A. Carol, In Search of New Cures for Tuberculosis, Medicinal Chemistry 2007; 3 (3) . https://dx.doi.org/10.2174/157340607780620626
DOI https://dx.doi.org/10.2174/157340607780620626 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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