Abstract
NMDA receptors are linked to neuronal loss in stroke and neurodegeneration because their activation can triggerexcitotoxic Ca2+ dysregulation. Accordingly, NMDA receptor antagonists are neuroprotective, providing a rationale fortheir clinical application. However, side effects often outweigh benefits. Herein we highlight structural properties inreceptors that are used in drug development.
Keywords: Glutamate, excitotoxicity, NMDA receptor, therapeutics, neurodegeneration, drug design
Mini-Reviews in Medicinal Chemistry
Title: Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies
Volume: 6 Issue: 7
Author(s): A. M. Gerber and M. L. Vallano
Affiliation:
Keywords: Glutamate, excitotoxicity, NMDA receptor, therapeutics, neurodegeneration, drug design
Abstract: NMDA receptors are linked to neuronal loss in stroke and neurodegeneration because their activation can triggerexcitotoxic Ca2+ dysregulation. Accordingly, NMDA receptor antagonists are neuroprotective, providing a rationale fortheir clinical application. However, side effects often outweigh benefits. Herein we highlight structural properties inreceptors that are used in drug development.
Export Options
About this article
Cite this article as:
Gerber M. A. and Vallano L. M., Structural Properties of the NMDA Receptor and the Design of Neuroprotective Therapies, Mini-Reviews in Medicinal Chemistry 2006; 6 (7) . https://dx.doi.org/10.2174/138955706777698651
DOI https://dx.doi.org/10.2174/138955706777698651 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Drugs and mitochondria
Mitochondria play a central role in the life and death of cells. They are not merely the center for energy metabolism but are also the headquarters for different catabolic and anabolic processes, calcium fluxes, and various signaling pathways. Mitochondria maintain homeostasis in the cell by interacting with reactive oxygen-nitrogen species ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer’s, Parkinson’s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Prevalence of Tooth Wear in Primary Dentition in School Children of Abu Dhabi, UAE
Applied Clinical Research, Clinical Trials and Regulatory Affairs Revolutionary Impact of Nanodrug Delivery on Neuroscience
Current Neuropharmacology Pharmacogenetics of Target Genes Across Doxorubicin Disposition Pathway: A Review
Current Drug Metabolism Genetics of Bladder-Exstrophy-Epispadias Complex (BEEC): Systematic Elucidation of Mendelian and Multifactorial Phenotypes
Current Genomics Therapeutic Drugs that Slow the Heart Rate of Early Rat Embryos. Is there a Risk for the Human?
Current Pharmaceutical Design Seizure Prediction on EEG Signals using Feature Augmentation based Multi Model Ensemble
Recent Patents on Engineering Brain Endothelial Cell-Cell Junctions: How to “Open” the Blood Brain Barrier
Current Neuropharmacology Neuroprotection by NMDA Receptor Antagonists in a Variety of Neuropathologies
Current Drug Targets Metabotropic Glutamate Receptors Modulate Periaqueductal Grey Descending Analgesic System
Central Nervous System Agents in Medicinal Chemistry Recent Advances in Synaptosomal Proteomics in Alzheimer’s Disease
Current Protein & Peptide Science Aluminum Vaccine Adjuvants: Are they Safe?
Current Medicinal Chemistry Synthesis, Anticonvulsant Evaluation of 2,3,4,5-Tetrahydro-7-alkoxy-1H-2-benzazepin-1-ones
Letters in Drug Design & Discovery PET with Non-Standard Nuclides
Current Topics in Medicinal Chemistry The Use of <i>Cannabis</i> and Cannabinoid-based Products by Pregnant Women: A Patent Review
Recent Patents on Biotechnology Natural Polymeric Nanoparticles for Brain-Targeting: Implications on Drug and Gene Delivery
Current Pharmaceutical Design Standardization and Pharmacological Evaluation of <i>Ziziphus mauritiana</i> Extract for Sedative and Anticonvulsant Activity in Mice and Rat
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Is the Modulation of Autophagy the Future in the Treatment of Neurodegenerative Diseases?
Current Topics in Medicinal Chemistry Therapeutic Drug Monitoring of Phenytoin by Simple, Rapid, Accurate, Highly Sensitive and Novel Method and Its Clinical Applications
Current Pharmaceutical Biotechnology BDZs, Designer BDZs and Z-drugs: Pharmacology and Misuse Insights
Current Pharmaceutical Design Analysis of Electrical Brain Waves in Neurotoxicology: Gamma- Hydroxybutyrate
Current Neuropharmacology