Abstract
IMGT®, the international ImMunoGeneTics information system® (http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune system (RPI) of any species. RPI include proteins that belong to the immunoglobulin superfamily (IgSF) and MHC superfamily (MhcSF). IMGT has set up a unique numbering system, which takes into account the structural features of the Ig-like and Mhc-like domains. In this paper, we describe the IMGT Scientific chart rules for the description of the IgSF V type and C type and of the MhcSF G type domains. These rules are based on the IMGT-ONTOLOGY concepts and are applicable for the sequence and structure analysis, whatever the species, the IgSF or MhcSF protein, or the chain type. We present examples of IMGT Colliers de Perles of IgSF V type (V-DOMAIN and V-LIKE-DOMAIN), C type (C-DOMAIN and C-LIKE-DOMAIN) and MhcSF G type (G-DOMAIN and G-LIKE-DOMAIN) based on the IMGT unique numbering. These standardized two-dimensional graphical representations are particularly useful for antibody engineering, sequence- structure analysis, visualization and comparison of positions for mutations, polymorphisms and contact analysis.
Keywords: IMGT, immunoglobulin superfamily, major histocompatibility complex superfamily, domain alignment, Ig-like, Mhc-like
Current Bioinformatics
Title: IMGT Colliers de Perles: Standardized Sequence-Structure Representations of the IgSF and MhcSF Superfamily Domains
Volume: 2 Issue: 1
Author(s): Quentin Kaas and Marie-Paule Lefranc
Affiliation:
Keywords: IMGT, immunoglobulin superfamily, major histocompatibility complex superfamily, domain alignment, Ig-like, Mhc-like
Abstract: IMGT®, the international ImMunoGeneTics information system® (http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrates, and related proteins of the immune system (RPI) of any species. RPI include proteins that belong to the immunoglobulin superfamily (IgSF) and MHC superfamily (MhcSF). IMGT has set up a unique numbering system, which takes into account the structural features of the Ig-like and Mhc-like domains. In this paper, we describe the IMGT Scientific chart rules for the description of the IgSF V type and C type and of the MhcSF G type domains. These rules are based on the IMGT-ONTOLOGY concepts and are applicable for the sequence and structure analysis, whatever the species, the IgSF or MhcSF protein, or the chain type. We present examples of IMGT Colliers de Perles of IgSF V type (V-DOMAIN and V-LIKE-DOMAIN), C type (C-DOMAIN and C-LIKE-DOMAIN) and MhcSF G type (G-DOMAIN and G-LIKE-DOMAIN) based on the IMGT unique numbering. These standardized two-dimensional graphical representations are particularly useful for antibody engineering, sequence- structure analysis, visualization and comparison of positions for mutations, polymorphisms and contact analysis.
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Cite this article as:
Kaas Quentin and Lefranc Marie-Paule, IMGT Colliers de Perles: Standardized Sequence-Structure Representations of the IgSF and MhcSF Superfamily Domains, Current Bioinformatics 2007; 2 (1) . https://dx.doi.org/10.2174/157489307779314302
DOI https://dx.doi.org/10.2174/157489307779314302 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
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