Abstract
The synthesis and evaluation as hypoxic selective cytotoxins of new derivatives of 2-amino or 2- hydroxyphenazine 5,10-dioxide are described. The compounds were developed as structural analogs of other bioreductive compounds and its in vitro cytotoxicities on V79 cells under hypoxic and aerobic conditions were determined. To gain insight into its mechanism of action electrochemical behavior, interaction with DNA experiments and QSAR studies were performed.
Keywords: Phenazine 5, 10-dioxide derivatives, bioreductive compounds, DNA, cyclic voltammetry
Medicinal Chemistry
Title: Phenazine 5,10-Dioxide Derivatives as Hypoxic Selective Cytotoxins: Part II. Structure-Activity Relationship Studies
Volume: 2 Issue: 5
Author(s): H. Cerecetto, M. Gonzalez, M. L. Lavaggi, M. A. Aravena, C. Rigol, C. Olea-Azar, A. Azqueta, A. Lopez de Cerain, A. Monge and A. M. Bruno
Affiliation:
Keywords: Phenazine 5, 10-dioxide derivatives, bioreductive compounds, DNA, cyclic voltammetry
Abstract: The synthesis and evaluation as hypoxic selective cytotoxins of new derivatives of 2-amino or 2- hydroxyphenazine 5,10-dioxide are described. The compounds were developed as structural analogs of other bioreductive compounds and its in vitro cytotoxicities on V79 cells under hypoxic and aerobic conditions were determined. To gain insight into its mechanism of action electrochemical behavior, interaction with DNA experiments and QSAR studies were performed.
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Cerecetto H., Gonzalez M., Lavaggi L. M., Aravena A. M., Rigol C., Olea-Azar C., Azqueta A., Lopez de Cerain A., Monge A. and Bruno M. A., Phenazine 5,10-Dioxide Derivatives as Hypoxic Selective Cytotoxins: Part II. Structure-Activity Relationship Studies, Medicinal Chemistry 2006; 2 (5) . https://dx.doi.org/10.2174/157340606778250207
DOI https://dx.doi.org/10.2174/157340606778250207 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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