Abstract
Epigenetics include DNA methylation, the modification of histone tails that affect chromatin states, and small RNAs that are involved in the setting and maintenance of chromatin modifications. Marine stramenopiles (MAS), which are a diverse assemblage of algae that acquired photosynthesis from secondary endosymbiosis, include single-celled organisms such as diatoms as well as multicellular forms such as brown algae. The recent publication of two diatom genomes that diverged ∼90 million years ago (mya), as well as the one of a brown algae that diverged from diatoms ∼250 Mya, provide a great system of related, yet diverged set of organisms to compare epigenetic marks and their relationships. For example, putative DNA methyltransferase homologues were found in diatoms while none could be identified in the brown algal genome. On the other hand, no canonical DICER-like protein was found in diatoms in contrast to what is observed in brown algae. A key interest relies in understanding the adaptive nature of epigenetics and its inheritability. In contrast to yeast that lack DNA methylation, homogeneous cultures of diatoms constitute an attractive system to study epigenetic changes in response to environmental conditions such as nutrient-rich to nutrient-poor transitions which is especially relevant because of their ecological importance. P. tricornutum is also of outstanding interest because it is observed as three different morphotypes and thus constitutes a simple and promising model for the study of the epigenetic phenomena that accompany cellular differentiation. In this review we focus on the insights obtained from MAS comparative genomics and epigenomic analyses.
Keywords: Marine stramenopiles, epigenomics, DNA methylation, chromatin, diatom, genomics, Small RNA, Brown algae, Transposable elements, HISTONE MODIFICATIONS
Current Genomics
Title: Stemming Epigenetics in Marine Stramenopiles
Volume: 12 Issue: 5
Author(s): Florian Maumus, Pablo Rabinowicz, Chris Bowler and Maximo Rivarola
Affiliation:
Keywords: Marine stramenopiles, epigenomics, DNA methylation, chromatin, diatom, genomics, Small RNA, Brown algae, Transposable elements, HISTONE MODIFICATIONS
Abstract: Epigenetics include DNA methylation, the modification of histone tails that affect chromatin states, and small RNAs that are involved in the setting and maintenance of chromatin modifications. Marine stramenopiles (MAS), which are a diverse assemblage of algae that acquired photosynthesis from secondary endosymbiosis, include single-celled organisms such as diatoms as well as multicellular forms such as brown algae. The recent publication of two diatom genomes that diverged ∼90 million years ago (mya), as well as the one of a brown algae that diverged from diatoms ∼250 Mya, provide a great system of related, yet diverged set of organisms to compare epigenetic marks and their relationships. For example, putative DNA methyltransferase homologues were found in diatoms while none could be identified in the brown algal genome. On the other hand, no canonical DICER-like protein was found in diatoms in contrast to what is observed in brown algae. A key interest relies in understanding the adaptive nature of epigenetics and its inheritability. In contrast to yeast that lack DNA methylation, homogeneous cultures of diatoms constitute an attractive system to study epigenetic changes in response to environmental conditions such as nutrient-rich to nutrient-poor transitions which is especially relevant because of their ecological importance. P. tricornutum is also of outstanding interest because it is observed as three different morphotypes and thus constitutes a simple and promising model for the study of the epigenetic phenomena that accompany cellular differentiation. In this review we focus on the insights obtained from MAS comparative genomics and epigenomic analyses.
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Cite this article as:
Maumus Florian, Rabinowicz Pablo, Bowler Chris and Rivarola Maximo, Stemming Epigenetics in Marine Stramenopiles, Current Genomics 2011; 12 (5) . https://dx.doi.org/10.2174/138920211796429727
DOI https://dx.doi.org/10.2174/138920211796429727 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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