Abstract
High dietary intake of fruits and vegetables is consistently associated with a reduced risk of common human cancers. The specific mechanisms of action of most phytochemicals in cancer prevention are not yet clear but appear to be varied. One class of compounds currently under investigation is flavonoids, a large group of molecules with similar structure. Although their bioavailability is discussed, numerous in vitro and animal model data suggest that flavonoids modulate important cellular and molecular mechanisms related to carcinogenesis, a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor cells. Epidemiological studies confirmed that, among many flavonoids, apigenin, epigallocatechin gallate, delphinidin and genistein appear to be beneficial compounds in various stages of carcinogenesis. Therefore, according to in vitro and in vivo studies, this review attempts to increase our understanding about the preventive and therapeutic effects of these compounds to facilitate extrapolation of results from animal studies to human situations.
Keywords: Flavonoids, apigenin, EGCG, delphinidin, genistein, angiogenesis, carcinogenesis, tumor initiation, tumor progression, metastasis, tumor microenvironment
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: Anticancer Properties of Flavonoids: Roles in Various Stages of Carcinogenesis
Volume: 9 Issue: 2
Author(s): Nicolas Clere, Sebastien Faure, Maria Carmen Martinez and Ramaroson Andriantsitohaina
Affiliation:
Keywords: Flavonoids, apigenin, EGCG, delphinidin, genistein, angiogenesis, carcinogenesis, tumor initiation, tumor progression, metastasis, tumor microenvironment
Abstract: High dietary intake of fruits and vegetables is consistently associated with a reduced risk of common human cancers. The specific mechanisms of action of most phytochemicals in cancer prevention are not yet clear but appear to be varied. One class of compounds currently under investigation is flavonoids, a large group of molecules with similar structure. Although their bioavailability is discussed, numerous in vitro and animal model data suggest that flavonoids modulate important cellular and molecular mechanisms related to carcinogenesis, a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor cells. Epidemiological studies confirmed that, among many flavonoids, apigenin, epigallocatechin gallate, delphinidin and genistein appear to be beneficial compounds in various stages of carcinogenesis. Therefore, according to in vitro and in vivo studies, this review attempts to increase our understanding about the preventive and therapeutic effects of these compounds to facilitate extrapolation of results from animal studies to human situations.
Export Options
About this article
Cite this article as:
Clere Nicolas, Faure Sebastien, Carmen Martinez Maria and Andriantsitohaina Ramaroson, Anticancer Properties of Flavonoids: Roles in Various Stages of Carcinogenesis, Cardiovascular & Hematological Agents in Medicinal Chemistry 2011; 9 (2) . https://dx.doi.org/10.2174/187152511796196498
DOI https://dx.doi.org/10.2174/187152511796196498 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Psychiatric Comorbidities in Inflammatory Bowel Disease
Current Psychiatry Reviews The Ca2+-Activated K+ Channel of Intermediate Conductance:A Molecular Target for Novel Treatments?
Current Drug Targets Short-term RR-Interval Power Spectral Analysis as a New Tool to Stratify the Risk of Sudden Death in Various Cardiovascular Conditions
Vascular Disease Prevention (Discontinued) Targeting the Endocannabinod System to Limit Myocardial and Cerebral Ischemic and Reperfusion Injury
Current Pharmaceutical Biotechnology Ezetimibe and Reactive Oxygen Species
Current Vascular Pharmacology Theoretical and Evidence-Based Benefit of Afterload Reduction in the Postoperative Pediatric Heart
Current Vascular Pharmacology Patent Selections
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Tobacco Smoking and Association between Betel Nut Chewing and Metabolic Abnormalities Among Military Males: The CHIEF Study
Endocrine, Metabolic & Immune Disorders - Drug Targets Pleiotropic Effects of Glucagon-like Peptide-1 (GLP-1)-Based Therapies on Vascular Complications in Diabetes
Current Pharmaceutical Design Cardiac Side Effects of Chemotherapy: State of Art and Strategies for a Correct Management
Current Vascular Pharmacology Hydrogen Sulphide in Heart and Systemic Circulation
Inflammation & Allergy - Drug Targets (Discontinued) An Efficient Machine Learning Model for Prediction of Acute Myocardial Infarction
Recent Advances in Computer Science and Communications Role of β 2-Adrenoceptor Activation in Sepsis-Induced Renal Inflammation
Current Immunology Reviews (Discontinued) Role of the Autonomic Nervous System and Neuropeptides in the Development of Obesity in Humans: Targets for Therapy?
Current Pharmaceutical Design The Optimal Treatment of Thyroid Gland Function Disturbances During Pregnancy
Current Pharmaceutical Biotechnology Therapies Targeting Innate Immunity for Fighting Inflammation in Atherosclerosis
Current Pharmaceutical Design α-Lipoic Acid Supplementation: A Tool for Obesity Therapy?
Current Pharmaceutical Design Minocycline Repurposing in Critical Illness: Focus on Stroke
Current Topics in Medicinal Chemistry The Missed Tc-99m Radiopharmaceuticals for Cardiac Imaging
Current Radiopharmaceuticals Organophosphorus Compounds: Intervention in Mechanisms of Signal Transduction Relevant to Proliferative, Immunological and Circulatory Disorders
Current Medicinal Chemistry