Abstract
In the past three decades, powder X-ray diffraction (PXRD) analysis was widely used in the characterization of cyclodextrins (CDs) and their inclusion complexes. In this paper, representative PXRD spectra of all kinds of CD complexes reported in these years were reviewed. First of all, after comparing XRD spectra of CD hydrates, we found that some of water molecules crystallized in a crystal form played an important role in constructing a three-dimension structure. Next, differences and similarities in PXRD spectra of the inclusion complexes formed by CDs with organic compounds, polymers and transition metal coordination compounds were evaluated systematically. According to the results, the geometric differences in spatial structures of CD supramolecules were associated with the different intermolecular interactions due to different inclusion behaviors between CDs and guests. Finally, several influence factors for the PXRD spectra of CD complexes were summarized.
Keywords: Crystal structure, cyclodextrin, inclusion complex, molecular arrangement, powder X-ray diffraction, supramolecule
Current Organic Chemistry
Title: Applications of Powder X-Ray Diffraction to Inclusion Complexes of Cyclodextrins
Volume: 15 Issue: 6
Author(s): Zheng Dang, Le Xin Song, Xue Qing Guo, Fang Yun Du, Jun Yang and Jing Yang
Affiliation:
Keywords: Crystal structure, cyclodextrin, inclusion complex, molecular arrangement, powder X-ray diffraction, supramolecule
Abstract: In the past three decades, powder X-ray diffraction (PXRD) analysis was widely used in the characterization of cyclodextrins (CDs) and their inclusion complexes. In this paper, representative PXRD spectra of all kinds of CD complexes reported in these years were reviewed. First of all, after comparing XRD spectra of CD hydrates, we found that some of water molecules crystallized in a crystal form played an important role in constructing a three-dimension structure. Next, differences and similarities in PXRD spectra of the inclusion complexes formed by CDs with organic compounds, polymers and transition metal coordination compounds were evaluated systematically. According to the results, the geometric differences in spatial structures of CD supramolecules were associated with the different intermolecular interactions due to different inclusion behaviors between CDs and guests. Finally, several influence factors for the PXRD spectra of CD complexes were summarized.
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Cite this article as:
Dang Zheng, Xin Song Le, Qing Guo Xue, Yun Du Fang, Yang Jun and Yang Jing, Applications of Powder X-Ray Diffraction to Inclusion Complexes of Cyclodextrins, Current Organic Chemistry 2011; 15 (6) . https://dx.doi.org/10.2174/138527211794518899
DOI https://dx.doi.org/10.2174/138527211794518899 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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