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Abstract
Tumor angiogenesis, i.e. the development of neovascularisation in and around solid tumors, plays a key role in the local and distant growth of cancer and anti-angiogenic treatments are now established strategies to treat cancer patients. Specific inhibitors of angiogenesis such as bevacizumab or receptor tyrosine kinase inhibitors targeting VEGFR or PDGFR are now in clinical trials and are being increasingly validated for the treatment of poor prognostic cancers. Other anti-angiogenic strategies such as cilengitide or metronomic chemotherapy (low-dose anti-angiogenic chemotherapy) have been developed to treat certain types of adult cancer. In children, the clinical potential of anti-angiogenic approach is still in an early stage of investigation. This review will focus on the role of angiogenesis in pediatric solid tumors and will describe the pre-clinical and clinical experience with several anti-angiogenic compounds as a potential treatment for children with cancer.
Keywords: Children, oncology, angiogenesis, treatment, metronomic, VEGF, Tyrosine kinase inhibitors.
Current Cancer Drug Targets
Title:Anti-Angiogenic Therapies for Children with Cancer
Volume: 10 Issue: 8
Author(s): N. Andre, A. Verschuur, J. Rossler and J. Sterba
Affiliation:
Keywords: Children, oncology, angiogenesis, treatment, metronomic, VEGF, Tyrosine kinase inhibitors.
Abstract: Tumor angiogenesis, i.e. the development of neovascularisation in and around solid tumors, plays a key role in the local and distant growth of cancer and anti-angiogenic treatments are now established strategies to treat cancer patients. Specific inhibitors of angiogenesis such as bevacizumab or receptor tyrosine kinase inhibitors targeting VEGFR or PDGFR are now in clinical trials and are being increasingly validated for the treatment of poor prognostic cancers. Other anti-angiogenic strategies such as cilengitide or metronomic chemotherapy (low-dose anti-angiogenic chemotherapy) have been developed to treat certain types of adult cancer. In children, the clinical potential of anti-angiogenic approach is still in an early stage of investigation. This review will focus on the role of angiogenesis in pediatric solid tumors and will describe the pre-clinical and clinical experience with several anti-angiogenic compounds as a potential treatment for children with cancer.
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Cite this article as:
Andre N., Verschuur A., Rossler J. and Sterba J., Anti-Angiogenic Therapies for Children with Cancer, Current Cancer Drug Targets 2010; 10 (8) . https://dx.doi.org/10.2174/156800910793357899
DOI https://dx.doi.org/10.2174/156800910793357899 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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