Abstract
Biocompatible nano-composite sol (NCS) comprising nano-crystalline hydroxyapatite (HAp, Ca 10(PO4)6(OH)2) and hyaluronic acid (HYA) was prepared. By varying the relative content of HAp in NCS, strongest network structure was obtained at 10wt% HAp in NCS, as confirmed from a number of circumstance evidences obtained by rheological, thermoanalytical, crystallographical measurements as well as FT-IR spectra. Interaction of NCS with natural bones and gut strings made from gut collagen was then examined in vitro. Adhesion of the collagen fibers with NCS was observed at the fracture surface of natural bones. Gut collagen was disentangled to the fragments of about 10 nm thick, where no NCS was observed, thus, confirming the fact that the adhesive strength between NCS and bone surface is stronger than that among collagen fibers.
Keywords: Biocompatible nano-composite sol, Hydroxyapatite, Hyaluronic acid, Collagen fibers, Adhesive strength
Current Nanoscience
Title: Properties of Hydroxyapatite - Hyaluronic Acid Nano-Composite Sol and its Interaction with Natural Bones and Collagen Fibers
Volume: 2 Issue: 3
Author(s): Y. Ishikawa, J. Komotori and M. Senna
Affiliation:
Keywords: Biocompatible nano-composite sol, Hydroxyapatite, Hyaluronic acid, Collagen fibers, Adhesive strength
Abstract: Biocompatible nano-composite sol (NCS) comprising nano-crystalline hydroxyapatite (HAp, Ca 10(PO4)6(OH)2) and hyaluronic acid (HYA) was prepared. By varying the relative content of HAp in NCS, strongest network structure was obtained at 10wt% HAp in NCS, as confirmed from a number of circumstance evidences obtained by rheological, thermoanalytical, crystallographical measurements as well as FT-IR spectra. Interaction of NCS with natural bones and gut strings made from gut collagen was then examined in vitro. Adhesion of the collagen fibers with NCS was observed at the fracture surface of natural bones. Gut collagen was disentangled to the fragments of about 10 nm thick, where no NCS was observed, thus, confirming the fact that the adhesive strength between NCS and bone surface is stronger than that among collagen fibers.
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Cite this article as:
Ishikawa Y., Komotori J. and Senna M., Properties of Hydroxyapatite - Hyaluronic Acid Nano-Composite Sol and its Interaction with Natural Bones and Collagen Fibers, Current Nanoscience 2006; 2 (3) . https://dx.doi.org/10.2174/1573413710602030191
DOI https://dx.doi.org/10.2174/1573413710602030191 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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