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Abstract
Oncolytic viral therapy is a promising biological therapy for the treatment of cancer. Recent advances in genetic engineering have facilitated the construction of custom-built oncolytic viruses that can be exquisitely targeted to tumors by exploiting each cancers unique biology and their efficacy can be further enhanced by “arming” them with additional therapeutic genes. Such an approach allows the virus to unload its “therapeutic cargo” at the tumor site, thereby enhancing its anti-neoplastic properties. While several clever strategies have been recently described using genes that can induce cellular apoptosis/suicide and/or facilitate tumor/virus imaging, viruses armed with genes that also affect the tumor microenvironment present an exciting and promising approach to therapy. In this review we discuss recently developed oncolytic viruses armed with genes encoding for angiostatic factors, inflammatory cytokines, or proteases that modulate the extracellular matrix to regulate tumor vascularization, anti-tumor immune responses and viral spread throughout the solid tumor.
Keywords: Oncolytic viruses, tumor microenvironment, angiogenesis, extracellular matrix, cytokines
Current Gene Therapy
Title: “Buy One Get One Free”: Armed Viruses for the Treatment of Cancer Cells and their Microenvironment
Volume: 9 Issue: 5
Author(s): Balveen Kaur, Timothy P. Cripe and E. Antonio Chiocca
Affiliation:
Keywords: Oncolytic viruses, tumor microenvironment, angiogenesis, extracellular matrix, cytokines
Abstract: Oncolytic viral therapy is a promising biological therapy for the treatment of cancer. Recent advances in genetic engineering have facilitated the construction of custom-built oncolytic viruses that can be exquisitely targeted to tumors by exploiting each cancers unique biology and their efficacy can be further enhanced by “arming” them with additional therapeutic genes. Such an approach allows the virus to unload its “therapeutic cargo” at the tumor site, thereby enhancing its anti-neoplastic properties. While several clever strategies have been recently described using genes that can induce cellular apoptosis/suicide and/or facilitate tumor/virus imaging, viruses armed with genes that also affect the tumor microenvironment present an exciting and promising approach to therapy. In this review we discuss recently developed oncolytic viruses armed with genes encoding for angiostatic factors, inflammatory cytokines, or proteases that modulate the extracellular matrix to regulate tumor vascularization, anti-tumor immune responses and viral spread throughout the solid tumor.
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Cite this article as:
Kaur Balveen, Cripe P. Timothy and Chiocca Antonio E., “Buy One Get One Free”: Armed Viruses for the Treatment of Cancer Cells and their Microenvironment, Current Gene Therapy 2009; 9 (5) . https://dx.doi.org/10.2174/156652309789753329
DOI https://dx.doi.org/10.2174/156652309789753329 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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