Abstract
A smooth and rapid one step synthesis of novel pyrido[2,3:3,4]pyrazolo[1,5-a]pyrimidines 4a,b and 7, pyrido[2,3:3,4]pyrazolo[5,1-c]triazines10-12a,b, pyrido[3“,2“:4,5]thieno[3,2:4,5]pyrimido/triazino[1,6-a]benzimidazoles 15-20 in synthetically useful yields utilizing, 3-amino-4-phenyl-5-(saccharin-2-yl)-1H-pyrazolo[3,4-b]pyridine (3) were described. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. Preliminary biological studies of some synthesized compounds showed promising antimicrobial activities.
Current Organic Chemistry
Title: A Synthetic Approach and Antimicrobial Evaluation of Annulated Pyrimidine and Triazine Derivatives
Volume: 13 Issue: 17
Author(s): A. A. Aly
Affiliation:
Abstract: A smooth and rapid one step synthesis of novel pyrido[2,3:3,4]pyrazolo[1,5-a]pyrimidines 4a,b and 7, pyrido[2,3:3,4]pyrazolo[5,1-c]triazines10-12a,b, pyrido[3“,2“:4,5]thieno[3,2:4,5]pyrimido/triazino[1,6-a]benzimidazoles 15-20 in synthetically useful yields utilizing, 3-amino-4-phenyl-5-(saccharin-2-yl)-1H-pyrazolo[3,4-b]pyridine (3) were described. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. Preliminary biological studies of some synthesized compounds showed promising antimicrobial activities.
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Cite this article as:
Aly A. A., A Synthetic Approach and Antimicrobial Evaluation of Annulated Pyrimidine and Triazine Derivatives, Current Organic Chemistry 2009; 13 (17) . https://dx.doi.org/10.2174/138527209789578090
DOI https://dx.doi.org/10.2174/138527209789578090 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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