Abstract
The reactivity of 5-hydroxy-6-methyluracil (HMU) towards peroxyl radicals generated from the aerobic thermal decomposition of 2,2-azo-bis(2-amidinopropane)dihydrochloride (AAPH) has been investigated. The oxidation product of HMU is dihydro-5,5,6-trihydroxy-6-methylpyrimidin-2,4-dion-e (94%). The relative oxidation rate of HMU vs. quercetin by peroxyl radicals generated from AAPH has been measured as 0.20 ± 0.04 at 54.6°C, hence HMU is the effective scavenger of peroxyl radicals. The overall kinetic parameters and the efficiency of radical generation from AAPH in water solution at pH 7.0 (0.1 M phosphate buffer) have been determined using HMU in temperature range 26° - 84°C.
Current Organic Chemistry
Title: 5-Hydroxy-6-methyluracil, an Efficient Scavenger of Peroxyl Radical in Water
Volume: 13 Issue: 17
Author(s): S. A. Grabovskiy, A. R. Abdrakhmanova, Y. I. Murinov and N. N. Kabal'nova
Affiliation:
Abstract: The reactivity of 5-hydroxy-6-methyluracil (HMU) towards peroxyl radicals generated from the aerobic thermal decomposition of 2,2-azo-bis(2-amidinopropane)dihydrochloride (AAPH) has been investigated. The oxidation product of HMU is dihydro-5,5,6-trihydroxy-6-methylpyrimidin-2,4-dion-e (94%). The relative oxidation rate of HMU vs. quercetin by peroxyl radicals generated from AAPH has been measured as 0.20 ± 0.04 at 54.6°C, hence HMU is the effective scavenger of peroxyl radicals. The overall kinetic parameters and the efficiency of radical generation from AAPH in water solution at pH 7.0 (0.1 M phosphate buffer) have been determined using HMU in temperature range 26° - 84°C.
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Grabovskiy A. S., Abdrakhmanova R. A., Murinov I. Y. and Kabal'nova N. N., 5-Hydroxy-6-methyluracil, an Efficient Scavenger of Peroxyl Radical in Water, Current Organic Chemistry 2009; 13 (17) . https://dx.doi.org/10.2174/138527209789578081
DOI https://dx.doi.org/10.2174/138527209789578081 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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