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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

1,4-Diazabicyclo[2.2.2]octane (DABCO) in Organic Synthesis and Catalysis: A Quinquennial Report (2019-to date)

Author(s): Ravi Varala*, Vittal Seema, Mohammed Mujahid Alam*, Mohammed Amanullah and Beda Durga Prasad

Volume 28, Issue 17, 2024

Published on: 12 June, 2024

Page: [1307 - 1345] Pages: 39

DOI: 10.2174/0113852728313865240528073519

Price: $65

Abstract

DABCO is one of the more effective basic organocatalysts/reagents that can be used for a range of organic transformations, including C-H functionalization, formation of hetero-hetero bonds, rearrangements, the synthesis of heterocyclic compounds, cyclizations and annulations, other miscellaneous reactions. This quinquennial review aims to critically and perceptively address noteworthy contributions of non chiral catalyst DABCO for regular organic transformations from 2019 onward. The key areas of attention were the advantages and limits of the approach, in addition to the mechanistic pathway, which is required for a specific organic transformation to be performed effectively.

Keywords: DABCO, base, organocatalyst, catalysis, organic synthesis, C-H functionalization, heterocyclic ring formation, cyclization.

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