Oleogels for the Promotion of Healthy Skin Care Products: Synthesis and Characterization of Allantoin Containing Moringa-based Oleogel

Title:Oleogels for the Promotion of Healthy Skin Care Products: Synthesis and Characterization of Allantoin Containing Moringa-based Oleogel

Volume: 25 Issue: 17

Author(s): Nazia Yaqoob*, Fazeelat Imtiaz, Nusrat Shafiq*, Saima Rehman, Huma Munir, Mohammed Bourhia*, Khalid S. Almaary and Hiba-Allah Nafidi

Affiliation:

• Green Chemistry Lab, Department of Chemistry, Government College Women University Faisalabad, 38000, Faisalabad, Pakistan

• Synthetic and Natural Products drug discovery Lab., Department of Chemistry, Government College Women University Faisalabad, 38000, Faisalabad, Pakistan

• Department of Chemistry and Biochemistry, Faculty of Medicine and Pharmacy, Ibn Zohr University, Laayoune 70000, Morocco

Keywords: Allantoin, chitosan, eucalyptus, M. olifera, oleogels, oleoemulsion, pectin.

Abstract:

Background: Oleogelation is an efficient and emerging approach for obtaining biocompatible and biodegradable elastic semisolid crystals to be used in various cosmetic and pharmaceutical formulations. Recently, drug incorporation in oil structuring has been a promising strategy under consideration due to the effectiveness of this method. Plant oils have very beneficial characteristics for skin care and wound healing due to the presence of certain antioxidants.

Methods: In this study, the oleogels of Moringa oleifera seed oil with natural polysaccharides, including pectin, chitosan, and xanthan gum, were prepared using the emulsion template method. Moringa oil was selected because it can hydrate and moisturize the skin and has great antioxidant activity. Also, the natural polysaccharides, i.e., pectin and chitosan, exhibited good gelling properties. Allantoin, which is a wound healer and eucalyptus leaf oil with antioxidant potential, was incorporated into the emulsion-based-oleogels to enhance the antioxidant and antimicrobial activity of the oleogels.

Results: Allantoin and eucalyptus-loaded oleogels exhibited good antibacterial activity against E. coli. The FTIR spectra of moringa-based oleogels in the range between 3226-3422 cm^-1 indicate the presence of hydrogen bonding in oleogels.

Conclusion: The antioxidant potential of allantoin and eucalyptus-containing oleogel was maximized, and an IC₅₀ value of 0.9719 μM was found. Maximum release of allantoin from oleogel was observed in the first hour.

Cite this article as:

Yaqoob Nazia*, Imtiaz Fazeelat, Shafiq Nusrat*, Rehman Saima, Munir Huma, Bourhia Mohammed*, Almaary S. Khalid and Nafidi Hiba-Allah, Oleogels for the Promotion of Healthy Skin Care Products: Synthesis and Characterization of Allantoin Containing Moringa-based Oleogel, Current Pharmaceutical Biotechnology 2024; 25 (17) . https://dx.doi.org/10.2174/0113892010295050240508114723