Abstract
Acyl ureas are a well-known class of organic compounds that have drawn a lot of attention recently because of their array of chemical properties and possible multi-use in medicine. The article summarizes the synthetic procedures used to produce various Acyl urea synthons and includes instances of clinical trials, patents, and commercialized medications having Acyl urea and N-acyl urea moiety. This extensive study examines and summarizes research on acyl urea derivatives conducted over the last 20 years from a variety of sources, including PubMed, Google Scholar, and Google Websites. When it comes to the discovery of new chemicals, urea derivatives still require attention compared to other acyl compounds. This review paper aims to provide a comprehensive overview of the various synthetic approaches utilized in the design of an array of acyl ureas to accomplish the same goal. This work summarizes information related to several heteroatom-fused acyl urea compounds, which fortunately will be a very useful resource for chemists and scientists who are interested in acyl urea synthesis and its applications in chemistry.
Keywords: Acyl ureas derivatives, organic compounds, chemical properties, marketed drugs, structure-activity relationship (SAR), pharmacological activity.
Current Organic Chemistry
Title:Multi-functional Acyl Urea Compounds: A Review on Related Patents, Clinical Trials, and Synthetic Approaches
Volume: 28 Issue: 17
Author(s): Janvi Rohilla, Rakhi Mishra*, Shruti Varshney, Avijit Mazumder, Rupa Mazumder, Arvind Kumar and Amrinder Kaur
Affiliation:
- Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida 201306, India
Keywords: Acyl ureas derivatives, organic compounds, chemical properties, marketed drugs, structure-activity relationship (SAR), pharmacological activity.
Abstract: Acyl ureas are a well-known class of organic compounds that have drawn a lot of attention recently because of their array of chemical properties and possible multi-use in medicine. The article summarizes the synthetic procedures used to produce various Acyl urea synthons and includes instances of clinical trials, patents, and commercialized medications having Acyl urea and N-acyl urea moiety. This extensive study examines and summarizes research on acyl urea derivatives conducted over the last 20 years from a variety of sources, including PubMed, Google Scholar, and Google Websites. When it comes to the discovery of new chemicals, urea derivatives still require attention compared to other acyl compounds. This review paper aims to provide a comprehensive overview of the various synthetic approaches utilized in the design of an array of acyl ureas to accomplish the same goal. This work summarizes information related to several heteroatom-fused acyl urea compounds, which fortunately will be a very useful resource for chemists and scientists who are interested in acyl urea synthesis and its applications in chemistry.
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Cite this article as:
Rohilla Janvi, Mishra Rakhi*, Varshney Shruti, Mazumder Avijit, Mazumder Rupa, Kumar Arvind and Kaur Amrinder, Multi-functional Acyl Urea Compounds: A Review on Related Patents, Clinical Trials, and Synthetic Approaches, Current Organic Chemistry 2024; 28 (17) . https://dx.doi.org/10.2174/0113852728307286240517054021
DOI https://dx.doi.org/10.2174/0113852728307286240517054021 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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