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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

阿尔茨海默病线粒体自噬的研究进展

卷 20, 期 12, 2023

发表于: 12 March, 2024

页: [827 - 844] 页: 18

弟呕挨: 10.2174/0115672050300063240305074310

摘要

随着老年人口的增加，阿尔茨海默病(AD)的患病率不断上升，损害了老年人的认知能力和生活自理能力。线粒体自噬的过程包括选择性清除老化和受损的线粒体，这是维持细胞内稳态和能量代谢所必需的。目前已经发现，自噬异常与AD的发生和发展密切相关。本文就AD的线粒体自噬机制、线粒体自噬异常及治疗效果作一综述。目的是为AD的病因和治疗提供新的视角。

关键词: 阿尔茨海默病(AD)，线粒体损伤，线粒体自噬，PINK1，帕金，体内平衡。

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