摘要
全肠外营养(TPN)是一种为无法通过正常消化过程或胃肠道系统满足其营养需求的个体直接向血液中提供营养的方法。它在一个容器中提供宏量营养素和微量营养素,减少了处理和污染风险,使其更具成本效益。TPN具有作为药物输送系统的潜力,可用于联合治疗、个性化医疗和整合先进技术。它可以提高药物剂量的准确性,并提供营养援助,有可能减少住院时间,改善患者的预后。然而,实施新的应用程序需要彻底的测试和监管部门的批准。TPN在儿科和老年保健方面可能特别有用,还可以通过在医疗资源有限的地区防治营养不良,为全球健康作出贡献。医疗保健专业人员根据每个病人的营养需求准备一种无菌溶液,并且管理涉及中心静脉导管。然而,与PN外加剂同时给药会导致药理学不相容性,从而影响水包油系统的稳定性。欧洲临床营养与代谢学会和美国肠外和肠内营养学会建议,出于安全考虑,不要在PN混合物中加入非营养性药物。本文综述了全肠外营养(TPN)作为一种给药方法的应用。讨论了其商业应用的好处和困难,并对未来的研究工作提出了建议。
关键词: 全肠外营养(TPN),给药,配方,生物相容性,稳定性,营养不良。
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