Perils and Problems in Bispecific T-Cell Engager Antibodies

Title:Perils and Problems in Bispecific T-Cell Engager Antibodies

Volume: 19

Author(s): Bisht Khushboo*Joshi Rajat Kumar

Affiliation:

• All India Institute of Medical Sciences, Rishikesh, India

Keywords: Immunotherapy, bispecific antibodies, cytokine release syndrome, neurotoxic, toxicity, BsAbs.

Abstract: Bispecific antibodies (BsAbs) are promising immunotherapies for cancer treatment designed to engage both tumour and immune cells. However, their use is associated with potential toxicities, including cytokine release syndrome (CRS), neurotoxicity, and on-target, off-tumour toxicity. CRS, characterized by cytokine release, is the most common, potentially life-threatening toxicity. Neurotoxicity presents as neurological symptoms and on-target, off-tumour toxicity damages healthy cells. Incidence and severity vary based on BsAb type, dose, patient factors, and tumor characteristics. For this study, articles pertaining to BsAb toxicity were searched on PubMed. Moreover, the management involves early recognition, dose modification, supportive care, and, in severe cases, immunosuppressive therapy or treatment discontinuation. Clinicians must carefully assess risks and benefits, considering individual patient profiles. Close monitoring and multidisciplinary collaboration are crucial for effective BsAb therapy. All in all, while toxicity is a concern, with vigilant management, BsAbs remain a valuable cancer treatment option.

Cite this article as:

Khushboo Bisht*, Kumar Rajat Joshi, Perils and Problems in Bispecific T-Cell Engager Antibodies, Current Drug Safety 2024; 19 () . https://dx.doi.org/10.2174/0115748863286774240219094217