Ocular Drug Delivery of Nanoparticles for Glaucoma

Title:Ocular Drug Delivery of Nanoparticles for Glaucoma

Volume: 19

Author(s): Aastha Dangwal*, Vikas Bhatt and Shiv Kumar Gupta

Affiliation:

• Pharmaceutics, Vikas Bhatt, Devsthali Vidyapeeth College of Pharmacy, Rudrapur, India

Keywords: IOP - Intra Ocular Pressure, HPH- High Pressure Homogenization, ACG - Angle-closure glucoma, OAG - open-angle glucoma, SLN - Solid Lipid Nanoparticles, HSH - High Speed Homogenization

Abstract: The nasolacrimal channels drain the medication from the pre-corneal area, causing the majority of the ophthalmic medication to be quickly removed following topical instillation. Over the past thirty years, newer medical techniques, such as in situ gel, nanoparticle, liposome, nanosuspension, microemulsion, iontophoresis, and occuserts have been created in an effort to overcome these challenges. These methods gradually and deliberately boost the drug's bioavailability. This article discusses ocular drug delivery for ophthalmics and its ideal characteristics, and also provides an insight on the use of nanotechnology in the form of nanoparticles used for the treatment of glaucoma in the eyes, employing HPH, ultrasonication/HSH, SE, SED technique, SFM, ME technique, SD method, DE method, PM, FUD, and other techniques to offer continuous and controlled IOP inside the eye chamber, make drug more ocularly bioavailable, and address a few pharmacological difficulties in ophthalmology. The creation of new drug delivery methods is currently gaining popularity, and this can facilitate the development of medicines for diseases that endanger eyesight.

Cite this article as:

Dangwal Aastha*, Bhatt Vikas and Gupta Kumar Shiv, Ocular Drug Delivery of Nanoparticles for Glaucoma, Current Drug Therapy 2024; 19 () . https://dx.doi.org/10.2174/0115748855278863240130074330