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当代肿瘤药物靶点

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Meta-Analysis

尼莫单抗联合放疗或放化疗治疗局部晚期头颈癌的疗效和安全性:一项系统综述和荟萃分析

卷 24, 期 9, 2024

发表于: 15 February, 2024

页: [952 - 966] 页: 15

弟呕挨: 10.2174/0115680096281982240117114819

价格: $65

摘要

背景:本荟萃分析旨在评估在放疗(RT)或放化疗(CRT)中加入尼莫单抗的疗效和安全性。 方法:检索EMBASE、PubMed和Cochrane图书馆2010年1月1日至2022年10月1日的前瞻性随机对照研究。总生存期(OS)、无进展生存期(PFS)、无病生存期(DFS)、完全缓解率(CRR)、客观缓解率(ORR)和所有级别不良事件的数据均从纳入的出版物中收集。OS是主要的测量指标。采用Stata SE 16.0软件对相对危险度(RRs)、危害危险度(HRs)及其对应的95%置信区间(ci)进行汇总分析。 结果:6个随机对照研究被纳入总体合并效应分析。与对照组相比,尼莫单抗干预组OS改善21%(合并HR=0.79,95% CI: 0.64-0.98, P=0.028), PFS改善31% (HR=0.69, 95% CI: 0.55-0.86, P=0.001), DFS改善29% (HR=0.71, 95% CI: 0.56-0.91, P=0.006), CRR提高50% (RR=1.50, 95% CI:1.09-2.04;P=0.012), ORR为35% (RR=1.35, 95% CI:1.04 ~ 1.73;P = 0.022)。在安全性方面,尼莫单抗联合RT或CRT并未增加所有级别不良事件的发生率(pooled-RD=-1.27, 95% CI:-2.78-0.23, P=0.099)。 结论:目前的荟萃分析表明,nimotuzumab联合RT或CRT可以提供生存益处并提高反应率。它的安全性是可控的。

关键词: 尼莫单抗,放疗,放化疗,头颈癌,鼻咽癌,靶向治疗。

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