Biodistribution and Tumor Targeted Accumulation of Anti-CEA-loaded Iron Nanoparticles

Title:Biodistribution and Tumor Targeted Accumulation of Anti-CEA-loaded Iron Nanoparticles

Volume: 25

Author(s): Thais Silva Correa, William Gustavo Lima, Aline Beatriz do Couto Campos, Alexsandro Sobreira Galdino*, Emilia Celma de Oliveira Lima, Valbert Nascimento Cardoso, Simone Odília Antunes Fernandes and Mariana Campos-da-Paz

Affiliation:

• Laboratory of Microbial Biotechnology, Federal University of Sao Joao Del-Rei, MG, 35500-291, Brazil

Keywords: breast cancer, magnetic nanoparticles, targeting, carcinoembryonic antigen, nanotechnology, theranostic

Abstract: Introduction: Active targeting of tumors by nanomaterials favors early diagnosis and the reduction of harsh side effects of chemotherapeuticals.

Method: We synthesized magnetic nanoparticles (64 nm; -40 mV) suspended in a magnetic fluid (MF) and decorated them with anti-carcinoembryonic antigen (MFCEA; 144 nm; -39 mV). MF and MFCEA nanoparticles were successfully radiolabeled with technetium–99m (99mTc) and intravenously injected in CEA-positive 4T1 tumor-bearing mice to perform biodistribution studies. Both 99mTc-MF and 99mTc-MFCEA had marked uptake by the liver and spleen, and the renal uptake of 99mTc-MFCEA was higher than that observed for 99mTc-MF at 20h. At 1 and 5 hours, the urinary excretion was higher for 99mTc-MF than for 99mTc-MFCEA.

Results: These data suggest that anti-CEA decoration might be responsible for a delay in renal clearance. Regarding the tumor, 99mTc-MFCEA showed tumor uptake nearly two times higher than that observed for 99mTc-MFCEA. Similarly, the target-nontarget ratio was higher with 99mTc-MFCEA when compared to the group that received the 99mTc-MF.

Conclusion: These data validated the ability of active tumor targeting by the as-developed antiCEA loaded nanoparticles and are very promising results for the future development of a nanodevice for the management of breast cancer and other types of CEA-positive tumors.

Cite this article as:

Correa Silva Thais, Lima Gustavo William, do Couto Campos Beatriz Aline, Galdino Sobreira Alexsandro*, de Oliveira Lima Celma Emilia, Cardoso Nascimento Valbert, Antunes Fernandes Simone Odília and Campos-da-Paz Mariana, Biodistribution and Tumor Targeted Accumulation of Anti-CEA-loaded Iron Nanoparticles, Current Pharmaceutical Biotechnology 2024; 25 () . https://dx.doi.org/10.2174/0113892010268872240104114444

DOI https://dx.doi.org/10.2174/0113892010268872240104114444	Print ISSN 1389-2010
Publisher Name Bentham Science Publisher	Online ISSN 1873-4316