Vitamin B12 Protects against Genotoxicity Induced by Cisplatin

Title:Vitamin B12 Protects against Genotoxicity Induced by Cisplatin

Volume: 24 Issue: 11

Author(s): Wejdan M. Al-Bataineh, Karem H. Alzoubi*, Omar F. Khabour, Amjad Mahasneh and Enaam M. Al Momany

Affiliation:

• Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, UAE
• Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, 22110, Jordan

Keywords: Vitamin B12, cisplatin, sister chromatid exchanges, chromosomal aberrations, mitotic index, genotoxicity.

Abstract:

Background: Cisplatin is an effective synthetic chemotherapeutic drug used for cancer treatment. Vitamin B12 has been shown to possess anti-genotoxic activity. This study aimed to investigate the effect of vitamin B12 on chromosomal damage induced by cisplatin.

Methods: The level of sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) were measured in cultured human blood lymphocytes treated with cisplatin and/or vitamin B12.

Results: The results showed a significantly elevated frequency of CAs and SCEs of cisplatin-treated cultures compared to the control (P < 0.05). The CAs and SCEs induced by cisplatin were significantly lowered by pretreatment of cell cultures with vitamin B12. In addition, cisplatin caused a slight reduction in the mitotic index (MI), while vitamin B12 did not modulate the effect of cisplatin on MI.

Conclusion: Vitamin B12 can protect human lymphocytes against genotoxicity associated with cisplatin.

Cite this article as:

Al-Bataineh M. Wejdan, Alzoubi H. Karem*, Khabour F. Omar, Mahasneh Amjad and Al Momany M. Enaam, Vitamin B12 Protects against Genotoxicity Induced by Cisplatin, Current Cancer Drug Targets 2024; 24 (11) . https://dx.doi.org/10.2174/0115680096284684240110044954