神经元素通过激活NF-κB信号通路促进非小细胞肺癌的进展

Thai, A.A.; Solomon, B.J.; Sequist, L.V.; Gainor, J.F.; Heist, R.S. Lung cancer. Lancet, 2021, 398(10299), 535-554.
[http://dx.doi.org/10.1016/S0140-6736(21)00312-3] [PMID: 34273294]

Melosky, B.; Wheatley-Price, P.; Juergens, R.A.; Sacher, A.; Leighl, N.B.; Tsao, M.S.; Cheema, P.; Snow, S.; Liu, G.; Card, P.B.; Chu, Q. The rapidly evolving landscape of novel targeted therapies in advanced non-small cell lung cancer. Lung Cancer, 2021, 160, 136-151.
[http://dx.doi.org/10.1016/j.lungcan.2021.06.002] [PMID: 34353680]

Reck, M.; Remon, J.; Hellmann, M.D. First-line immunotherapy for non-small cell lung cancer. J. Clin. Oncol., 2022, 40(6), 586-597.
[http://dx.doi.org/10.1200/JCO.21.01497] [PMID: 34985920]

Allemani, C.; Matsuda, T.; Di Carlo, V.; Harewood, R.; Matz, M.; Nikšić, M.; Bonaventure, A.; Valkov, M.; Johnson, C.J.; Estève, J.; Ogunbiyi, O.J.; Azevedo e Silva, G.; Chen, W.Q.; Eser, S.; Engholm, G.; Stiller, C.A.; Monnereau, A.; Woods, R.R.; Visser, O.; Lim, G.H.; Aitken, J.; Weir, H.K.; Coleman, M.P.; Bouzbid, S.; Hamdi-Chérif, M.; Zaidi, Z.; Meguenni, K.; Regagba, D.; Bayo, S.; Cheick Bougadari, T.; Manraj, S.S.; Bendahhou, K.; Fabowale, A.; Bradshaw, D.; Somdyala, N.I.M.; Kumcher, I.; Moreno, F.; Calabrano, G.H.; Espinola, S.B.; Carballo Quintero, B.; Fita, R.; Diumenjo, M.C.; Laspada, W.D.; Ibañez, S.G.; Lima, C.A.; De Souza, P.C.F.; Del Pino, K.; Laporte, C.; Curado, M.P.; de Oliveira, J.C.; Veneziano, C.L.A.; Veneziano, D.B.; Latorre, M.R.D.O.; Tanaka, L.F.; Rebelo, M.S.; Santos, M.O.; Galaz, J.C.; Aparicio Aravena, M.; Sanhueza Monsalve, J.; Herrmann, D.A.; Vargas, S.; Herrera, V.M.; Uribe, C.J.; Bravo, L.E.; Garcia, L.S.; Arias-Ortiz, N.E.; Morantes, D.; Jurado, D.M.; Yépez Chamorro, M.C.; Delgado, S.; Ramirez, M.; Galán Alvarez, Y.H.; Torres, P.; Martínez-Reyes, F.; Jaramillo, L.; Quinto, R.; Castillo, J.; Mendoza, M.; Cueva, P.; Yépez, J.G.; Bhakkan, B.; Deloumeaux, J.; Joachim, C.; Macni, J.; Carrillo, R.; Shalkow Klincovstein, J.; Rivera Gomez, R.; Poquioma, E.; Tortolero-Luna, G.; Zavala, D.; Alonso, R.; Barrios, E.; Eckstrand, A.; Nikiforuk, C.; Noonan, G.; Turner, D.; Kumar, E.; Zhang, B.; McCrate, F.R.; Ryan, S.; MacIntyre, M.; Saint-Jacques, N.; Nishri, D.E.; McClure, C.A.; Vriends, K.A.; Kozie, S.; Stuart-Panko, H.; Freeman, T.; George, J.T.; Brockhouse, J.T.; O’Brien, D.K.; Holt, A.; Almon, L.; Kwong, S.; Morris, C.; Rycroft, R.; Mueller, L.; Phillips, C.E.; Brown, H.; Cromartie, B.; Schwartz, A.G.; Vigneau, F.; Levin, G.M.; Wohler, B.; Bayakly, R.; Ward, K.C.; Gomez, S.L.; McKinley, M.; Cress, R.; Green, M.D.; Miyagi, K.; Ruppert, L.P.; Lynch, C.F.; Huang, B.; Tucker, T.C.; Deapen, D.; Liu, L.; Hsieh, M.C.; Wu, X.C.; Schwenn, M.; Gershman, S.T.; Knowlton, R.C.; Alverson, G.; Copeland, G.E.; Bushhouse, S.; Rogers, D.B.; Jackson-Thompson, J.; Lemons, D.; Zimmerman, H.J.; Hood, M.; Roberts-Johnson, J.; Rees, J.R.; Riddle, B.; Pawlish, K.S.; Stroup, A.; Key, C.; Wiggins, C.; Kahn, A.R.; Schymura, M.J.; Radhakrishnan, S.; Rao, C.; Giljahn, L.K.; Slocumb, R.M.; Espinoza, R.E.; Khan, F.; Aird, K.G.; Beran, T.; Rubertone, J.J.; Slack, S.J.; Garcia, L.; Rousseau, D.L.; Janes, T.A.; Schwartz, S.M.; Bolick, S.W.; Hurley, D.M.; Whiteside, M.A.; Miller-Gianturco, P.; Williams, M.A.; Herget, K.; Sweeney, C.; Johnson, A.T.; Keitheri Cheteri, M.B.; Migliore Santiago, P.; Blankenship, S.E.; Farley, S.; Borchers, R.; Malicki, R.; Espinoza, J.R.; Grandpre, J.; Wilson, R.; Edwards, B.K.; Mariotto, A.; Lei, Y.; Wang, N.; Chen, J.S.; Zhou, Y.; He, Y.T.; Song, G.H.; Gu, X.P.; Mei, D.; Mu, H.J.; Ge, H.M.; Wu, T.H.; Li, Y.Y.; Zhao, D.L.; Jin, F.; Zhang, J.H.; Zhu, F.D.; Junhua, Q.; Yang, Y.L.; Jiang, C.X.; Biao, W.; Wang, J.; Li, Q.L.; Yi, H.; Zhou, X.; Dong, J.; Li, W.; Fu, F.X.; Liu, S.Z.; Chen, J.G.; Zhu, J.; Li, Y.H.; Lu, Y.Q.; Fan, M.; Huang, S.Q.; Guo, G.P.; Zhaolai, H.; Wei, K.; Zeng, H.; Demetriou, A.V.; Mang, W.K.; Ngan, K.C.; Kataki, A.C.; Krishnatreya, M.; Jayalekshmi, P.A.; Sebastian, P.; Nandakumar, A.; Malekzadeh, R.; Roshandel, G.; Keinan-Boker, L.; Silverman, B.G.; Ito, H.; Nakagawa, H.; Sato, M.; Tobori, F.; Nakata, I.; Teramoto, N.; Hattori, M.; Kaizaki, Y.; Moki, F.; Sugiyama, H.; Utada, M.; Nishimura, M.; Yoshida, K.; Kurosawa, K.; Nemoto, Y.; Narimatsu, H.; Sakaguchi, M.; Kanemura, S.; Naito, M.; Narisawa, R.; Miyashiro, I.; Nakata, K.; Sato, S.; Yoshii, M.; Oki, I.; Fukushima, N.; Shibata, A.; Iwasa, K.; Ono, C.; Nimri, O.; Jung, K.W.; Won, Y.J.; Alawadhi, E.; Elbasmi, A.; Ab Manan, A.; Adam, F.; Sanjaajmats, E.; Tudev, U.; Ochir, C.; Al Khater, A.M.; El Mistiri, M.M.; Teo, Y.Y.; Chiang, C.J.; Lee, W.C.; Buasom, R.; Sangrajrang, S.; Kamsa-ard, S.; Wiangnon, S.; Daoprasert, K.; Pongnikorn, D.; Leklob, A.; Sangkitipaiboon, S.; Geater, S.L.; Sriplung, H.; Ceylan, O.; Kög, I.; Dirican, O.; Köse, T.; Gurbuz, T.; Karaşahin, F.E.; Turhan, D.; Aktaş, U.; Halat, Y.; Yakut, C.I.; Altinisik, M.; Cavusoglu, Y.; Türkköylü, A.; Üçüncü, N.; Hackl, M.; Zborovskaya, A.A.; Aleinikova, O.V.; Henau, K.; Van Eycken, L.; Valerianova, Z.; Yordanova, M.R.; Šekerija, M.; Dušek, L.; Zvolský, M.; Storm, H.; Innos, K.; Mägi, M.; Malila, N.; Seppä, K.; Jégu, J.; Velten, M.; Cornet, E.; Troussard, X.; Bouvier, A.M.; Guizard, A.V.; Bouvier, V.; Launoy, G.; Arveux, P.; Maynadié, M.; Mounier, M.; Woronoff, A.S.; Daoulas, M.; Robaszkiewicz, M.; Clavel, J.; Goujon, S.; Lacour, B.; Baldi, I.; Pouchieu, C.; Amadeo, B.; Coureau, G.; Orazio, S.; Preux, P.M.; Rharbaoui, F.; Marrer, E.; Trétarre, B.; Colonna, M.; Delafosse, P.; Ligier, K.; Plouvier, S.; Cowppli-Bony, A.; Molinié, F.; Bara, S.; Ganry, O.; Lapôtre-Ledoux, B.; Grosclaude, P.; Bossard, N.; Uhry, Z.; Bray, F.; Piñeros, M.; Stabenow, R.; Wilsdorf-Köhler, H.; Eberle, A.; Luttmann, S.; Löhden, I.; Nennecke, A.L.; Kieschke, J.; Sirri, E.; Emrich, K.; Zeissig, S.R.; Holleczek, B.; Eisemann, N.; Katalinic, A.; Asquez, R.A.; Kumar, V.; Petridou, E.; Ólafsdóttir, E.J.; Tryggvadóttir, L.; Clough-Gorr, K.; Walsh, P.M.; Sundseth, H.; Mazzoleni, G.; Vittadello, F.; Coviello, E.; Cuccaro, F.; Galasso, R.; Sampietro, G.; Giacomin, A.; Magoni, M.; Ardizzone, A.; D’Argenzio, A.; Castaing, M.; Grosso, G.; Lavecchia, A.M.; Sutera Sardo, A.; Gola, G.; Gatti, L.; Ricci, P.; Ferretti, S.; Serraino, D.; Zucchetto, A.; Celesia, M.V.; Filiberti, R.A.; Pannozzo, F.; Melcarne, A.; Quarta, F.; Russo, A.G.; Carrozzi, G.; Cirilli, C.; Cavalieri d’Oro, L.; Rognoni, M.; Fusco, M.; Vitale, M.F.; Usala, M.; Cusimano, R.; Mazzucco, W.; Michiara, M.; Sgargi, P.; Boschetti, L.; Borciani, E.; Seghini, P.; Maule, M.M.; Merletti, F.; Tumino, R.; Mancuso, P.; Vicentini, M.; Cassetti, T.; Sassatelli, R.; Falcini, F.; Giorgetti, S.; Caiazzo, A.L.; Cavallo, R.; Cesaraccio, R.; Pirino, D.R.; Contrino, M.L.; Tisano, F.; Fanetti, A.C.; Maspero, S.; Carone, S.; Mincuzzi, A.; Candela, G.; Scuderi, T.; Gentilini, M.A.; Piffer, S.; Rosso, S.; Barchielli, A.; Caldarella, A.; Bianconi, F.; Stracci, F.; Contiero, P.; Tagliabue, G.; Rugge, M.; Zorzi, M.; Beggiato, S.; Brustolin, A.; Berrino, F.; Gatta, G.; Sant, M.; Buzzoni, C.; Mangone, L.; Capocaccia, R.; De Angelis, R.; Zanetti, R.; Maurina, A.; Pildava, S.; Lipunova, N.; Vincerževskiené, I.; Agius, D.; Calleja, N.; Siesling, S.; Larønningen, S.; Møller, B.; Dyzmann-Sroka, A.; Trojanowski, M.; Góźdź, S.; Mężyk, R.; Mierzwa, T.; Molong, L.; Rachtan, J.; Szewczyk, S.; Błaszczyk, J.; Kępska, K.; Kościańska, B.; Tarocińska, K.; Zwierko, M.; Drosik, K.; Maksimowicz, K.M.; Purwin-Porowska, E.; Reca, E.; Wójcik-Tomaszewska, J.; Tukiendorf, A.; Grądalska-Lampart, M.; Radziszewska, A.U.; Gos, A.; Talerczyk, M.; Wyborska, M.; Didkowska, J.A.; Wojciechowska, U.; Bielska-Lasota, M.; Forjaz de Lacerda, G.; Rego, R.A.; Bastos, J.; Silva, M.A.; Antunes, L.; Laranja Pontes, J.; Mayer-da-Silva, A.; Miranda, A.; Blaga, L.M.; Coza, D.; Gusenkova, L.; Lazarevich, O.; Prudnikova, O.; Vjushkov, D.M.; Egorova, A.G.; Orlov, A.E.; Kudyakov, L.A.; Pikalova, L.V.; Adamcik, J.; Safaei Diba, C.; Primic-Žakelj, M.; Zadnik, V.; Larrañaga, N.; Lopez de Munain, A.; Herrera, A.A.; Redondas, R.; Marcos-Gragera, R.; Vilardell Gil, M.L.; Molina, E.; Sánchez Perez, M.J.; Franch Sureda, P.; Ramos Montserrat, M.; Chirlaque, M.D.; Navarro, C.; Ardanaz, E.E.; Guevara, M.M.; Fernández-Delgado, R.; Peris-Bonet, R.; Carulla, M.; Galceran, J.; Alberich, C.; Vicente-Raneda, M.; Khan, S.; Pettersson, D.; Dickman, P.; Avelina, I.; Staehelin, K.; Camey, B.; Bouchardy, C.; Schaffar, R.; Frick, H.; Herrmann, C.; Bulliard, J.L.; Maspoli-Conconi, M.; Kuehni, C.E.; Redmond, S.M.; Bordoni, A.; Ortelli, L.; Chiolero, A.; Konzelmann, I.; Matthes, K.L.; Rohrmann, S.; Broggio, J.; Rashbass, J.; Fitzpatrick, D.; Gavin, A.; Clark, D.I.; Deas, A.J.; Huws, D.W.; White, C.; Montel, L.; Rachet, B.; Turculet, A.D.; Stephens, R.; Chalker, E.; Phung, H.; Walton, R.; You, H.; Guthridge, S.; Johnson, F.; Gordon, P.; D’Onise, K.; Priest, K.; Stokes, B.C.; Venn, A.; Farrugia, H.; Thursfield, V.; Dowling, J.; Currow, D.; Hendrix, J.; Lewis, C. Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): Analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet, 2018, 391(10125), 1023-1075.
[http://dx.doi.org/10.1016/S0140-6736(17)33326-3] [PMID: 29395269]

Monteiro, A.S.; Araújo, S.R.C.; Araujo, L.H.; Souza, M.C. Impact of microvascular invasion on 5-year overall survival of resected non-small cell lung cancer. J. Bras. Pneumol., 2022, 48(3), e20210283.
[http://dx.doi.org/10.36416/1806-3756/e20210283] [PMID: 35830051]

Pitale, P.M.; Howse, W.; Gorbatyuk, M. Neuronatin protein in health and disease. J. Cell. Physiol., 2017, 232(3), 477-481.
[http://dx.doi.org/10.1002/jcp.25498] [PMID: 27442611]

Xu, D.S.; Yang, C.; Proescholdt, M.; Bründl, E.; Brawanski, A.; Fang, X.; Lee, C.S.; Weil, R.J.; Zhuang, Z.; Lonser, R.R. Neuronatin in a subset of glioblastoma multiforme tumor progenitor cells is associated with increased cell proliferation and shorter patient survival. PLoS One, 2012, 7(5), e37811.
[http://dx.doi.org/10.1371/journal.pone.0037811] [PMID: 22624064]

Siu, I.M.; Bai, R.; Gallia, G.L.; Edwards, J.B.; Tyler, B.M.; Eberhart, C.G.; Riggins, G.J. Coexpression of neuronatin splice forms promotes medulloblastoma growth. Neuro-oncol., 2008, 10(5), 716-724.
[http://dx.doi.org/10.1215/15228517-2008-038] [PMID: 18701710]

Okubo, C.; Minami, Y.; Tanaka, R.; Uchihara, T.; Anami, Y.; Furuya, S.; Morishita, Y.; Iijima, T.; Noguchi, M. Analysis of differentially expressed genes in neuroendocrine carcinomas of the lung. J. Thorac. Oncol., 2006, 1(8), 780-786.
[http://dx.doi.org/10.1016/S1556-0864(15)30406-8] [PMID: 17409960]

Uchihara, T.; Okubo, C.; Tanaka, R.; Minami, Y.; Inadome, Y.; Iijima, T.; Morishita, Y.; Fujita, J.; Noguchi, M. Neuronatin expression and its clinicopathological significance in pulmonary non-small cell carcinoma. J. Thorac. Oncol., 2007, 2(9), 796-801.
[http://dx.doi.org/10.1097/JTO.0b013e318145af5e] [PMID: 17805055]

Cimino, I.; Rimmington, D.; Tung, Y.C.L.; Lawler, K.; Larraufie, P.; Kay, R.G.; Virtue, S.; Lam, B.Y.H.; Fagnocchi, L.; Ma, M.K.L.; Saudek, V.; Zvetkova, I.; Vidal-Puig, A.; Yeo, G.S.H.; Farooqi, I.S.; Pospisilik, J.A.; Gribble, F.M.; Reimann, F.; O’Rahilly, S.; Coll, A.P. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity. Sci. Rep., 2021, 11(1), 17571.
[http://dx.doi.org/10.1038/s41598-021-96278-8] [PMID: 34475432]

Braun, J.L.; Teng, A.C.T.; Geromella, M.S.; Ryan, C.R.; Fenech, R.K.; MacPherson, R.E.K.; Gramolini, A.O.; Fajardo, V.A. Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high-fat diet-fed mice. FEBS Lett., 2021, 595(22), 2756-2767.
[http://dx.doi.org/10.1002/1873-3468.14213] [PMID: 34693525]

Braun, J.L.; Geromella, M.S.; Hamstra, S.I.; Fajardo, V.A. Neuronatin regulates whole-body metabolism: Is thermogenesis involved? FASEB Bioadv., 2020, 2(10), 579-586.
[http://dx.doi.org/10.1096/fba.2020-00052] [PMID: 33089074]

Schulz, R.; McCole, R.B.; Woodfine, K.; Wood, A.J.; Chahal, M.; Monk, D.; Moore, G.E.; Oakey, R.J. Transcript- and tissue-specific imprinting of a tumour suppressor gene. Hum. Mol. Genet., 2009, 18(1), 118-127.
[http://dx.doi.org/10.1093/hmg/ddn322] [PMID: 18836209]

Higashi, M.; Tajiri, T.; Kinoshita, Y.; Tatsuta, K.; Souzaki, R.; Maehara, Y.; Suita, S.; Taguchi, T. High expressions of neuronatin isoforms in favorable neuroblastoma. J. Pediatr. Hematol. Oncol., 2007, 29(8), 551-556.
[http://dx.doi.org/10.1097/MPH.0b013e3181256b7b] [PMID: 17762496]

Deng, Y.; Lu, L.; Liang, X.; Li, J.; Zhu, D.; Huang, H.; Zhang, Y.; Zhang, X.; Chen, Y.; Liu, X.; Fu, Y. DNA methylation-mediated silencing of Neuronatin promotes hepatocellular carcinoma proliferation through the PI3K-Akt signaling pathway. Life Sci., 2023, 312, 121266.
[http://dx.doi.org/10.1016/j.lfs.2022.121266] [PMID: 36473542]

Saeed, H.; Sinha, S.; Mella, C.; Kuerbitz, J.S.; Cales, M.L.; Steele, M.A.; Stanke, J.; Damron, D.; Safadi, F.; Kuerbitz, S.J. Aberrant epigenetic silencing of neuronatin is a frequent event in human osteosarcoma. Oncotarget, 2020, 11(20), 1876-1893.
[http://dx.doi.org/10.18632/oncotarget.27583] [PMID: 32499872]

Pieper, W.; Ignatov, A.; Kalinski, T.; Haybaeck, J.; Czapiewski, P.; Nass, N. The predictive potential of Neuronatin for neoadjuvant chemotherapy of breast cancer. Cancer Biomark., 2021, 32(2), 161-173.
[http://dx.doi.org/10.3233/CBM-203127] [PMID: 34092612]

Ryu, S.; McDonnell, K.; Choi, H.; Gao, D.; Hahn, M.; Joshi, N.; Park, S.M.; Catena, R.; Do, Y.; Brazin, J.; Vahdat, L.T.; Silver, R.B.; Mittal, V. Suppression of miRNA-708 by polycomb group promotes metastases by calcium-induced cell migration. Cancer Cell, 2013, 23(1), 63-76.
[http://dx.doi.org/10.1016/j.ccr.2012.11.019] [PMID: 23328481]

Yang, J.; Wei, J.; Wu, Y.; Wang, Z.; Guo, Y.; Lee, P.; Li, X. Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer. Oncogenesis, 2015, 4(6), e158.
[http://dx.doi.org/10.1038/oncsis.2015.18] [PMID: 26075749]

Rasmi, R.R.; Sakthivel, K.M.; Guruvayoorappan, C. NF-κB inhibitors in treatment and prevention of lung cancer. Biomed. Pharmacother., 2020, 130, 110569.
[http://dx.doi.org/10.1016/j.biopha.2020.110569] [PMID: 32750649]

Pastor, M.D.; Nogal, A.; Molina-Pinelo, S.; Meléndez, R.; Salinas, A.; González De la Peña, M.; Martín-Juan, J.; Corral, J.; García-Carbonero, R.; Carnero, A.; Paz-Ares, L. Identification of proteomic signatures associated with lung cancer and COPD. J. Proteomics, 2013, 89, 227-237.
[http://dx.doi.org/10.1016/j.jprot.2013.04.037] [PMID: 23665002]

Guttridge, D.C.; Albanese, C.; Reuther, J.Y.; Pestell, R.G.; Baldwin, A.S., Jr NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol., 1999, 19(8), 5785-5799.
[http://dx.doi.org/10.1128/MCB.19.8.5785] [PMID: 10409765]

Gyrd-Hansen, M.; Meier, P. IAPs: From caspase inhibitors to modulators of NF-κB, inflammation and cancer. Nat. Rev. Cancer, 2010, 10(8), 561-574.
[http://dx.doi.org/10.1038/nrc2889] [PMID: 20651737]

Zhao, H.; Wu, L.; Yan, G.; Chen, Y.; Zhou, M.; Wu, Y.; Li, Y. Inflammation and tumor progression: Signaling pathways and targeted intervention. Signal Transduct. Target. Ther., 2021, 6(1), 263.
[http://dx.doi.org/10.1038/s41392-021-00658-5] [PMID: 34248142]

Yang, C.J.; Liu, Y.P.; Dai, H.Y.; Shiue, Y.L.; Tsai, C.J.; Huang, M.S.; Yeh, Y.T. Nuclear HDAC6 inhibits invasion by suppressing NF-κB/MMP2 and is inversely correlated with metastasis of non-small cell lung cancer. Oncotarget, 2015, 6(30), 30263-30276.
[http://dx.doi.org/10.18632/oncotarget.4749] [PMID: 26388610]

Mzhavia, N.; Yu, S.; Ikeda, S.; Chu, T.T.; Goldberg, I.; Dansky, H.M. Neuronatin: A new inflammation gene expressed on the aortic endothelium of diabetic mice. Diabetes, 2008, 57(10), 2774-2783.
[http://dx.doi.org/10.2337/db07-1746] [PMID: 18591389]

Gysler, S.M.; Drapkin, R. Tumor innervation: Peripheral nerves take control of the tumor microenvironment. J. Clin. Invest., 2021, 131(11), e147276.
[http://dx.doi.org/10.1172/JCI147276] [PMID: 34060481]

Saloman, J.L.; Albers, K.M.; Rhim, A.D.; Davis, B.M. Can stopping nerves, stop cancer? Trends Neurosci., 2016, 39(12), 880-889.
[http://dx.doi.org/10.1016/j.tins.2016.10.002] [PMID: 27832915]

Cervantes-Villagrana, R.D.; Albores-García, D.; Cervantes-Villagrana, A.R.; García-Acevez, S.J. Tumor-induced neurogenesis and immune evasion as targets of innovative anti-cancer therapies. Signal Transduct. Target. Ther., 2020, 5(1), 99.
[http://dx.doi.org/10.1038/s41392-020-0205-z] [PMID: 32555170]

Talmadge, J.E.; Fidler, I.J. AACR centennial series: The biology of cancer metastasis: historical perspective. Cancer Res., 2010, 70(14), 5649-5669.
[http://dx.doi.org/10.1158/0008-5472.CAN-10-1040] [PMID: 20610625]

Joseph, R.M. Neuronatin gene: Imprinted and misfolded. Genomics, 2014, 103(2-3), 183-188.
[http://dx.doi.org/10.1016/j.ygeno.2013.12.001] [PMID: 24345642]

Li, B.; Xu, H.; He, C.; Zou, W.; Tu, Y. Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation. J. Toxicol. Sci., 2021, 46(7), 329-339.
[http://dx.doi.org/10.2131/jts.46.329] [PMID: 34193770]