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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Case Report

RAD54L突变与男性尿道勒氏透明细胞癌的新关联:关于一种罕见肿瘤分子机制的新见解

卷 24, 期 10, 2024

发表于: 25 January, 2024

页: [1080 - 1087] 页: 8

弟呕挨: 10.2174/0115680096260943231212043820

价格: $65

摘要

导读:男性尿道缪勒氏透明细胞癌在形态和免疫组化表达上与女性生殖道相似，但临床很少观察到。 病例介绍:在这里，我们报告一例65岁的男性被诊断为缪勒氏透明细胞癌，他携带RAD54L突变。该患者经电灼诊断，最终行前列腺切除术。经过六个月的随访，没有发现复发或其他恶性肿瘤的迹象。根据我们对现有文献的分析，迄今为止似乎没有报道过伴有RAD54L突变的缪勒氏透明细胞癌。 结论:本病例增强了我们对男性尿道缪勒氏透明细胞癌分子生物学的认识，这将有助于临床医生对这种具有特定驱动突变的罕见癌症患者选择最佳治疗方案。

关键词: 缪勒氏透明细胞癌，RAD54L基因，男性尿道，新一代测序，治疗，预后。

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