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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Mini-Review Article

Recent Progress in the Synthetic Methods of Pyrazoloquinoline Derivatives

Author(s): Rita M. Borik, Mohamed S. Mostafa, Mohamed S. Behalo and Rizk E. Khidre*

Volume 28, Issue 2, 2024

Published on: 23 January, 2024

Page: [117 - 133] Pages: 17

DOI: 10.2174/0113852728285959240108060645

Price: $65

Abstract

The focus of this review is on the synthetic routes available for different types of pyrazoloquinoline derivatives. There are three types of synthetic methods: i) from pyrazole derivatives; ii) from quinoline derivatives; and iii) miscellaneous methods. The position of the linkage between pyrazole and quinoline rings determines the seven isomers of pyrazoloquinolines. The purpose of this review is to provide a guide for both synthetic and medicinal chemists to discover and design new pyrazoloquinolines for medical purposes.

Keywords: Synthesis methods, heterocycles, pyrazoloquinoline, pyrazole, quinolines, pharmacological activities.

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