MicroRNAs Targeting Critical Molecular Pathways in Diabetic Cardiomyopathy Emerging Valuable for Therapy

Title:MicroRNAs Targeting Critical Molecular Pathways in Diabetic Cardiomyopathy Emerging Valuable for Therapy

Volume: 22 Issue: 3

Author(s): Priyanka Mathur, Sharad Saxena, Bhawna Saxena and Vibha Rani*

Affiliation:

• Center for Emerging Diseases, Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector- 62, Noida, 201307, Uttar Pradesh, India

Keywords: MicroRNAs, diabetes, cardiomyopathy, sarcomere, stress, glucose transporter.

Abstract:

MicroRNAs have emerged as an important regulator of post-transcriptional gene expression studied extensively in many cancers, fetal development, and cardiovascular diseases. Their endogenous nature and easy manipulation have made them potential diagnostic and therapeutic molecules. Diseases with complex pathophysiology such as Diabetic Cardiomyopathy display symptoms at a late stage when the risk of heart failure has become very high. Therefore, the utilization of microRNAs as a tool to study pathophysiology and device-sustainable treatments for DCM could be considered. The present review focuses on the mechanistic insights of diabetic cardiomyopathy and the potential role of microRNAs..

Cite this article as:

Mathur Priyanka, Saxena Sharad, Saxena Bhawna and Rani Vibha*, MicroRNAs Targeting Critical Molecular Pathways in Diabetic Cardiomyopathy Emerging Valuable for Therapy, Cardiovascular & Hematological Agents in Medicinal Chemistry 2024; 22 (3) . https://dx.doi.org/10.2174/0118715257265947231129074526