Immunologic Crosstalk of Endoplasmic Reticulum Stress Signaling in Bladder Cancer

Siegel, R.L.; Miller, K.D.; Fuchs, H.E.; Jemal, A. Cancer statistics, 2022. CA Cancer J. Clin., 2022, 72(1), 7-33.
[http://dx.doi.org/10.3322/caac.21708] [PMID: 35020204]

Chauhan, P.S.; Chen, K.; Babbra, R.K.; Feng, W.; Pejovic, N.; Nallicheri, A.; Harris, P.K.; Dienstbach, K.; Atkocius, A.; Maguire, L.; Qaium, F.; Szymanski, J.J.; Baumann, B.C.; Ding, L.; Cao, D.; Reimers, M.A.; Kim, E.H.; Smith, Z.L.; Arora, V.K.; Chaudhuri, A.A. Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study. PLoS Med., 2021, 18(8), e1003732.
[http://dx.doi.org/10.1371/journal.pmed.1003732] [PMID: 34464379]

Sung, H.; Ferlay, J.; Siegel, R.L.; Laversanne, M.; Soerjomataram, I.; Jemal, A.; Bray, F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 2021, 71(3), 209-249.
[http://dx.doi.org/10.3322/caac.21660] [PMID: 33538338]

Lenis, A.T.; Lec, P.M.; Chamie, K.; Mshs, M. Bladder cancer. JAMA, 2020, 324(19), 1980-1991.
[http://dx.doi.org/10.1001/jama.2020.17598] [PMID: 33201207]

Pettenati, C.; Ingersoll, M.A. Mechanisms of BCG immunotherapy and its outlook for bladder cancer. Nat. Rev. Urol., 2018, 15(10), 615-625.
[http://dx.doi.org/10.1038/s41585-018-0055-4] [PMID: 29991725]

Drake, C.G. Myeloid Resistance is not Futile: Biomarkers of Immunotherapy in Bladder Cancer. Clin. Cancer Res., 2021, 27(15), 4139-4141.
[http://dx.doi.org/10.1158/1078-0432.CCR-21-1011] [PMID: 34045294]

Kartolo, A.; Kassouf, W.; Vera-Badillo, F.E. Adjuvant immune checkpoint inhibition in muscle-invasive bladder cancer: Is it ready for prime time? Eur. Urol., 2021, 80(6), 679-681.
[http://dx.doi.org/10.1016/j.eururo.2021.07.019] [PMID: 34366212]

Trevisani, F.; Di Marco, F.; Raggi, D.; Bettiga, A.; Vago, R.; Larcher, A.; Cinque, A.; Salonia, A.; Briganti, A.; Capitanio, U.; Necchi, A.; Montorsi, F. Renal function outcomes in patients with muscle-invasive bladder cancer treated with neoadjuvant pembrolizumab and radical cystectomy in the PURE-01 study. Int. J. Cancer, 2021, 149(1), 186-190.
[http://dx.doi.org/10.1002/ijc.33554] [PMID: 33720424]

Mok, T.S.K.; Wu, Y.L.; Kudaba, I.; Kowalski, D.M.; Cho, B.C.; Turna, H.Z.; Castro, G., Jr; Srimuninnimit, V.; Laktionov, K.K.; Bondarenko, I.; Kubota, K.; Lubiniecki, G.M.; Zhang, J.; Kush, D.; Lopes, G.; Adamchuk, G.; Ahn, M-J.; Alexandru, A.; Altundag, O.; Alyasova, A.; Andrusenko, O.; Aoe, K.; Araujo, A.; Aren, O.; Arrieta Rodriguez, O.; Ativitavas, T.; Avendano, O.; Barata, F.; Barrios, C.H.; Beato, C.; Bergstrom, P.; Betticher, D.; Bolotina, L.; Bondarenko, I.; Botha, M.; Buddu, S.; Caglevic, C.; Cardona, A.; Castro, G., Jr; Castro, H.; Cay Senler, F.; Cerny, C.A.S.; Cesas, A.; Chan, G-C.; Chang, J.; Chen, G.; Chen, X.; Cheng, S.; Cheng, Y.; Cherciu, N.; Chiu, C-H.; Cho, B.C.; Cicenas, S.; Ciurescu, D.; Cohen, G.; Costa, M.A.; Danchaivijitr, P.; De Angelis, F.; de Azevedo, S.J.; Dediu, M.; Deliverski, T.; De Marchi, P.R.M.; de The Bustamante Valles, F.; Ding, Z.; Doganov, B.; Dreosti, L.; Duarte, R.; Edusma-Dy, R.; Emelyanov, S.; Erman, M.; Fan, Y.; Fein, L.; Feng, J.; Fenton, D.; Fernandes, G.; Ferreira, C.; Franke, F.A.; Freitas, H.; Fujisaka, Y.; Galindo, H.; Galvez, C.; Ganea, D.; Gil, N.; Girotto, G.; Goker, E.; Goksel, T.; Gomez Aubin, G.; Gomez Wolff, L.; Griph, H.; Gumus, M.; Hall, J.; Hart, G.; Havel, L.; He, J.; He, Y.; Hernandez Hernandez, C.; Hespanhol, V.; Hirashima, T.; Ho, C.M.J.; Horiike, A.; Hosomi, Y.; Hotta, K.; Hou, M.; How, S.H.; Hsia, T-C.; Hu, Y.; Ichiki, M.; Imamura, F.; Ivashchuk, O.; Iwamoto, Y.; Jaal, J.; Jassem, J.; Jordaan, C.; Juergens, R.A.; Kaen, D.; Kalinka-Warzocha, E.; Karaseva, N.; Karaszewska, B.; Kazarnowicz, A.; Kasahara, K.; Katakami, N.; Kato, T.; Kawaguchi, T.; Kim, J.H.; Kishi, K.; Kolek, V.; Koleva, M.; Kolman, P.; Koubkova, L.; Kowalyszyn, R.; Kowalski, D.; Koynov, K.; Ksienski, D.; Kubota, K.; Kudaba, I.; Kurata, T.; Kuusk, G.; Kuzina, L.; Laczo, I.; Ladrera, G.E.I.; Laktionov, K.; Landers, G.; Lazarev, S.; Lerzo, G.; Lesniewski Kmak, K.; Li, W.; Liam, C.K.; Lifirenko, I.; Lipatov, O.; Liu, X.; Liu, Z.; Lo, S.H.; Lopes, V.; Lopez, K.; Lu, S.; Martinengo, G.; Mas, L.; Matrosova, M.; Micheva, R.; Milanova, Z.; Miron, L.; Mok, T.; Molina, M.; Murakami, S.; Nakahara, Y.; Nguyen, T.Q.; Nishimura, T.; Ochsenbein, A.; Ohira, T.; Ohman, R.; Ong, C.K.; Ostoros, G.; Ouyang, X.; Ovchinnikova, E.; Ozyilkan, O.; Petruzelka, L.; Pham, X.D.; Picon, P.; Piko, B.; Poltoratsky, A.; Ponomarova, O.; Popelkova, P.; Purkalne, G.; Qin, S.; Ramlau, R.; Rappaport, B.; Rey, F.; Richardet, E.; Roubec, J.; Ruff, P.; Rusyn, A.; Saka, H.; Salas, J.; Sandoval, M.; Santos, L.; Sawa, T.; Seetalarom, K.; Seker, M.; Seki, N.; Seolwane, F.; Shepherd, L.; Shevnya, S.; Shimada, A.K.; Shparyk, Y.; Sinielnikov, I.; Sirbu, D.; Smaletz, O.; Soares, J.P.H.; Sookprasert, A.; Speranza, G.; Srimuninnimit, V.; Sriuranpong, V.; Stara, Z.; Su, W-C.; Sugawara, S.; Szpak, W.; Takahashi, K.; Takigawa, N.; Tanaka, H.; Tan Chun Bing, J.; Tang, Q.; Taranov, P.; Tejada, H.; Tho, L.M.; Torii, Y.; Trukhyn, D.; Turdean, M.; Turna, H.; Ursol, G.; Vanasek, J.; Varela, M.; Vallejo, M.; Vera, L.; Victorino, A-P.; Vlasek, T.; Vynnychenko, I.; Wang, B.; Wang, J.; Wang, K.; Wu, Y.; Yamada, K.; Yang, C-H.; Yokoyama, T.; Yokoyama, T.; Yoshioka, H.; Yumuk, F.; Zambrano, A.; Zarba, J.J.; Zarubenkov, O.; Zemaitis, M.; Zhang, L.; Zhang, L.; Zhang, X.; Zhao, J.; Zhou, C.; Zhou, J.; Zhou, Q.; Zippelius, A. Pembrolizumab versus chemotherapy for previously untreated, PD-L1-expressing, locally advanced or metastatic non-small-cell lung cancer (KEYNOTE-042): A randomised, open-label, controlled, phase 3 trial. Lancet, 2019, 393(10183), 1819-1830.
[http://dx.doi.org/10.1016/S0140-6736(18)32409-7] [PMID: 30955977]

Powles, T.; Kockx, M.; Rodriguez-Vida, A.; Duran, I.; Crabb, S.J.; Van Der Heijden, M.S.; Szabados, B.; Pous, A.F.; Gravis, G.; Herranz, U.A.; Protheroe, A.; Ravaud, A.; Maillet, D.; Mendez, M.J.; Suarez, C.; Linch, M.; Prendergast, A.; van Dam, P.J.; Stanoeva, D.; Daelemans, S.; Mariathasan, S.; Tea, J.S.; Mousa, K.; Banchereau, R.; Castellano, D. Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial. Nat. Med., 2019, 25(11), 1706-1714.
[http://dx.doi.org/10.1038/s41591-019-0628-7] [PMID: 31686036]

Necchi, A.; Raggi, D.; Gallina, A.; Madison, R.; Colecchia, M.; Lucianò, R.; Montironi, R.; Giannatempo, P.; Farè, E.; Pederzoli, F.; Bandini, M.; Bianchi, M.; Colombo, R.; Gandaglia, G.; Fossati, N.; Marandino, L.; Capitanio, U.; Dehò, F.; Ali, S.M.; Chung, J.H.; Ross, J.S.; Salonia, A.; Briganti, A.; Montorsi, F. Updated results of PURE-01 with preliminary activity of neoadjuvant pembrolizumab in patients with muscle-invasive bladder carcinoma with variant histologies. Eur. Urol., 2020, 77(4), 439-446.
[http://dx.doi.org/10.1016/j.eururo.2019.10.026] [PMID: 31708296]

Li, R.; Zhang, J.; Gilbert, S.M.; Conejo-Garcia, J.; Mulé, J.J. Using oncolytic viruses to ignite the tumour immune microenvironment in bladder cancer. Nat. Rev. Urol., 2021, 18(9), 543-555.
[http://dx.doi.org/10.1038/s41585-021-00483-z] [PMID: 34183833]

King, A.P.; Wilson, J.J. Endoplasmic reticulum stress: An arising target for metal-based anticancer agents. Chem. Soc. Rev., 2020, 49(22), 8113-8136.
[http://dx.doi.org/10.1039/D0CS00259C] [PMID: 32597908]

Akman, M.; Belisario, D.C.; Salaroglio, I.C.; Kopecka, J.; Donadelli, M.; De Smaele, E.; Riganti, C. Hypoxia, endoplasmic reticulum stress and chemoresistance: Dangerous liaisons. J. Exp. Clin. Cancer Res., 2021, 40(1), 28.
[http://dx.doi.org/10.1186/s13046-020-01824-3] [PMID: 33423689]

Song, M.; Cubillos-Ruiz, J.R. Endoplasmic reticulum stress responses in intratumoral immune cells: Implications for cancer immunotherapy. Trends Immunol., 2019, 40(2), 128-141.
[http://dx.doi.org/10.1016/j.it.2018.12.001] [PMID: 30612925]

Katoh, Y.; Yaguchi, T.; Kubo, A.; Iwata, T.; Morii, K.; Kato, D.; Ohta, S.; Satomi, R.; Yamamoto, Y.; Oyamada, Y.; Ouchi, K.; Takahashi, S.; Ishioka, C.; Matoba, R.; Suematsu, M.; Kawakami, Y. Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody. J. Immunother. Cancer, 2022, 10(7), e004616.
[http://dx.doi.org/10.1136/jitc-2022-004616] [PMID: 35793868]

Li, X.; Zheng, J.; Chen, S.; Meng, F.; Ning, J.; Sun, S. Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer. Cell Death Dis., 2021, 12(4), 314.
[http://dx.doi.org/10.1038/s41419-021-03605-y] [PMID: 33762577]

Li, W.; Yang, J.; Luo, L.; Jiang, M.; Qin, B.; Yin, H.; Zhu, C.; Yuan, X.; Zhang, J.; Luo, Z.; Du, Y.; Li, Q.; Lou, Y.; Qiu, Y.; You, J. Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death. Nat. Commun., 2019, 10(1), 3349.
[http://dx.doi.org/10.1038/s41467-019-11269-8] [PMID: 31350406]

Lau, T.S.; Chan, L.K.Y.; Man, G.C.W.; Wong, C.H.; Lee, J.H.S.; Yim, S.F.; Cheung, T.H.; McNeish, I.A.; Kwong, J. Paclitaxel Induces Immunogenic Cell Death in Ovarian Cancer via TLR4/IKK2/SNARE-Dependent Exocytosis. Cancer Immunol. Res., 2020, 8(8), 1099-1111.
[http://dx.doi.org/10.1158/2326-6066.CIR-19-0616] [PMID: 32354736]

Chen, X.; Cubillos-Ruiz, J.R. Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat. Rev. Cancer, 2021, 21(2), 71-88.
[http://dx.doi.org/10.1038/s41568-020-00312-2] [PMID: 33214692]

Dong, H.; Adams, N.M.; Xu, Y.; Cao, J.; Allan, D.S.J.; Carlyle, J.R.; Chen, X.; Sun, J.C.; Glimcher, L.H. The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc. Nat. Immunol., 2019, 20(7), 865-878.
[http://dx.doi.org/10.1038/s41590-019-0388-z] [PMID: 31086333]

Raines, L.N.; Zhao, H.; Wang, Y.; Chen, H.Y.; Gallart-Ayala, H.; Hsueh, P.C.; Cao, W.; Koh, Y.; Alamonte-Loya, A.; Liu, P.S.; Ivanisevic, J.; Lio, C.W.J.; Ho, P.C.; Huang, S.C.C. PERK is a critical metabolic hub for immunosuppressive function in macrophages. Nat. Immunol., 2022, 23(3), 431-445.
[http://dx.doi.org/10.1038/s41590-022-01145-x] [PMID: 35228694]

Hurst, K.E.; Lawrence, K.A.; Essman, M.T.; Walton, Z.J.; Leddy, L.R.; Thaxton, J.E. Endoplasmic reticulum stress contributes to mitochondrial exhaustion of CD8⁺ T Cells. Cancer Immunol. Res., 2019, 7(3), 476-486.
[http://dx.doi.org/10.1158/2326-6066.CIR-18-0182] [PMID: 30659052]

Marciniak, S.J.; Chambers, J.E.; Ron, D. Pharmacological targeting of endoplasmic reticulum stress in disease. Nat. Rev. Drug Discov., 2022, 21(2), 115-140.
[http://dx.doi.org/10.1038/s41573-021-00320-3] [PMID: 34702991]

Bhardwaj, M.; Leli, N.M.; Koumenis, C.; Amaravadi, R.K. Regulation of autophagy by canonical and non-canonical ER stress responses. Semin. Cancer Biol., 2020, 66, 116-128.
[http://dx.doi.org/10.1016/j.semcancer.2019.11.007] [PMID: 31838023]

Oakes, S.A. Endoplasmic reticulum stress signaling in cancer cells. Am. J. Pathol., 2020, 190(5), 934-946.
[http://dx.doi.org/10.1016/j.ajpath.2020.01.010] [PMID: 32112719]

Cerezo, M.; Rocchi, S. New anti-cancer molecules targeting HSPA5/BIP to induce endoplasmic reticulum stress, autophagy and apoptosis. Autophagy, 2017, 13(1), 216-217.
[http://dx.doi.org/10.1080/15548627.2016.1246107] [PMID: 27791469]

Hetz, C.; Zhang, K.; Kaufman, R.J. Mechanisms, regulation and functions of the unfolded protein response. Nat. Rev. Mol. Cell Biol., 2020, 21(8), 421-438.
[http://dx.doi.org/10.1038/s41580-020-0250-z] [PMID: 32457508]

da Silva, D.C.; Valentão, P.; Andrade, P.B.; Pereira, D.M. Endoplasmic reticulum stress signaling in cancer and neurodegenerative disorders: Tools and strategies to understand its complexity. Pharmacol. Res., 2020, 155, 104702.
[http://dx.doi.org/10.1016/j.phrs.2020.104702] [PMID: 32068119]

Madden, E.; Logue, S.E.; Healy, S.J.; Manie, S.; Samali, A. The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance. Biol. Cell, 2019, 111(1), 1-17.
[http://dx.doi.org/10.1111/boc.201800050] [PMID: 30302777]

Salaroglio, I.C.; Panada, E.; Moiso, E.; Buondonno, I.; Provero, P.; Rubinstein, M.; Kopecka, J.; Riganti, C. PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy. Mol. Cancer, 2017, 16(1), 91.
[http://dx.doi.org/10.1186/s12943-017-0657-0] [PMID: 28499449]

Zundell, J.A.; Fukumoto, T.; Lin, J.; Fatkhudinov, N.; Nacarelli, T.; Kossenkov, A.V.; Liu, Q.; Cassel, J.; Hu, C.C.A.; Wu, S.; Zhang, R. Targeting the IRE1α/XBP1 endoplasmic reticulum stress response pathway in ARID1A -mutant ovarian cancers. Cancer Res., 2021, 81(20), 5325-5335.
[http://dx.doi.org/10.1158/0008-5472.CAN-21-1545] [PMID: 34548333]

Stengel, S.T.; Fazio, A.; Lipinski, S.; Jahn, M.T.; Aden, K.; Ito, G.; Wottawa, F.; Kuiper, J.W.P.; Coleman, O.I.; Tran, F.; Bordoni, D.; Bernardes, J.P.; Jentzsch, M.; Luzius, A.; Bierwirth, S.; Messner, B.; Henning, A.; Welz, L.; Kakavand, N.; Falk-Paulsen, M.; Imm, S.; Hinrichsen, F.; Zilbauer, M.; Schreiber, S.; Kaser, A.; Blumberg, R.; Haller, D.; Rosenstiel, P. Activating transcription factor 6 mediates inflammatory signals in intestinal epithelial cells upon endoplasmic reticulum stress. Gastroenterology, 2020, 159(4), 1357-1374.e10.
[http://dx.doi.org/10.1053/j.gastro.2020.06.088] [PMID: 32673694]

Louessard, M.; Bardou, I.; Lemarchand, E.; Thiebaut, A.M.; Parcq, J.; Leprince, J.; Terrisse, A.; Carraro, V.; Fafournoux, P.; Bruhat, A.; Orset, C.; Vivien, D.; Ali, C.; Roussel, B.D. Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death. Cell Death Differ., 2017, 24(9), 1518-1529.
[http://dx.doi.org/10.1038/cdd.2017.35] [PMID: 28644439]

Xia, S.; Duan, W.; Liu, W.; Zhang, X.; Wang, Q. GRP78 in lung cancer. J. Transl. Med., 2021, 19(1), 118.
[http://dx.doi.org/10.1186/s12967-021-02786-6] [PMID: 33743739]

Fernandez, P.M.; Tabbara, S.O.; Jacobs, L.K.; Manning, F.C.R.; Tsangaris, T.N.; Schwartz, A.M.; Kennedy, K.A.; Patierno, S.R. Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions. Breast Cancer Res. Treat., 2000, 59(1), 15-26.
[http://dx.doi.org/10.1023/A:1006332011207] [PMID: 10752676]

Austgen, K.; Oakes, S.A.; Ganem, D. Multiple defects, including premature apoptosis, prevent Kaposi’s sarcoma-associated herpesvirus replication in murine cells. J. Virol., 2012, 86(3), 1877-1882.
[http://dx.doi.org/10.1128/JVI.06600-11] [PMID: 22130538]

Wang, M.; Kaufman, R.J. The impact of the endoplasmic reticulum protein-folding environment on cancer development. Nat. Rev. Cancer, 2014, 14(9), 581-597.
[http://dx.doi.org/10.1038/nrc3800] [PMID: 25145482]

Han, J.; Back, S.H.; Hur, J.; Lin, Y.H.; Gildersleeve, R.; Shan, J.; Yuan, C.L.; Krokowski, D.; Wang, S.; Hatzoglou, M.; Kilberg, M.S.; Sartor, M.A.; Kaufman, R.J. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nat. Cell Biol., 2013, 15(5), 481-490.
[http://dx.doi.org/10.1038/ncb2738] [PMID: 23624402]

Kepp, O.; Menger, L.; Vacchelli, E.; Locher, C.; Adjemian, S.; Yamazaki, T.; Martins, I.; Sukkurwala, A.Q.; Michaud, M.; Senovilla, L.; Galluzzi, L.; Kroemer, G.; Zitvogel, L. Crosstalk between ER stress and immunogenic cell death. Cytokine Growth Factor Rev., 2013, 24(4), 311-318.
[http://dx.doi.org/10.1016/j.cytogfr.2013.05.001] [PMID: 23787159]

Cubillos-Ruiz, J.R.; Bettigole, S.E.; Glimcher, L.H. Tumorigenic and immunosuppressive effects of endoplasmic reticulum stress in cancer. Cell, 2017, 168(4), 692-706.
[http://dx.doi.org/10.1016/j.cell.2016.12.004] [PMID: 28187289]

Chevet, E.; Hetz, C.; Samali, A. Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis. Cancer Discov., 2015, 5(6), 586-597.
[http://dx.doi.org/10.1158/2159-8290.CD-14-1490] [PMID: 25977222]

Görlach, A.; Bertram, K.; Hudecova, S.; Krizanova, O. Calcium and ROS: A mutual interplay. Redox Biol., 2015, 6, 260-271.
[http://dx.doi.org/10.1016/j.redox.2015.08.010] [PMID: 26296072]

Dong, L.; Krewson, E.; Yang, L. Acidosis activates endoplasmic reticulum stress pathways through GPR4 in human vascular endothelial cells. Int. J. Mol. Sci., 2017, 18(2), 278.
[http://dx.doi.org/10.3390/ijms18020278] [PMID: 28134810]

Song, M.; Sandoval, T.A.; Chae, C.S.; Chopra, S.; Tan, C.; Rutkowski, M.R.; Raundhal, M.; Chaurio, R.A.; Payne, K.K.; Konrad, C.; Bettigole, S.E.; Shin, H.R.; Crowley, M.J.P.; Cerliani, J.P.; Kossenkov, A.V.; Motorykin, I.; Zhang, S.; Manfredi, G.; Zamarin, D.; Holcomb, K.; Rodriguez, P.C.; Rabinovich, G.A.; Conejo-Garcia, J.R.; Glimcher, L.H.; Cubillos-Ruiz, J.R. IRE1α–XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity. Nature, 2018, 562(7727), 423-428.
[http://dx.doi.org/10.1038/s41586-018-0597-x] [PMID: 30305738]

Riesenberg, B.P.; Hunt, E.G.; Tennant, M.D.; Hurst, K.E.; Andrews, A.M.; Leddy, L.R.; Neskey, D.M.; Hill, E.G.; Rivera, G.O.R.; Paulos, C.M.; Gao, P.; Thaxton, J.E. Stress-mediated attenuation of translation undermines t-cell activity in cancer. Cancer Res., 2022, 82(23), 4386-4399.
[http://dx.doi.org/10.1158/0008-5472.CAN-22-1744] [PMID: 36126165]

Carew, J.S.; Nawrocki, S.T.; Krupnik, Y.V.; Dunner, K., Jr; McConkey, D.J.; Keating, M.J.; Huang, P. Targeting endoplasmic reticulum protein transport: A novel strategy to kill malignant B cells and overcome fludarabine resistance in CLL. Blood, 2006, 107(1), 222-231.
[http://dx.doi.org/10.1182/blood-2005-05-1923] [PMID: 16144803]

Chen, T.C.; Wang, W.; Golden, E.B.; Thomas, S.; Sivakumar, W.; Hofman, F.M.; Louie, S.G.; Schönthal, A.H. Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models. Cancer Lett., 2011, 302(2), 100-108.
[http://dx.doi.org/10.1016/j.canlet.2010.11.008] [PMID: 21257259]

Lu, T.; Gu, M.; Zhao, Y.; Zheng, X.; Xing, C. Autophagy contributes to falcarindiol-induced cell death in breast cancer cells with enhanced endoplasmic reticulum stress. PLoS One, 2017, 12(4), e0176348.
[http://dx.doi.org/10.1371/journal.pone.0176348] [PMID: 28441457]

Yardim, A.; Kandemir, F.M.; Ozdemir, S.; Kucukler, S.; Comakli, S.; Gur, C.; Celik, H. Quercetin provides protection against the peripheral nerve damage caused by vincristine in rats by suppressing caspase 3, NF-κB, ATF-6 pathways and activating Nrf2, Akt pathways. Neurotoxicology, 2020, 81, 137-146.
[http://dx.doi.org/10.1016/j.neuro.2020.10.001] [PMID: 33038355]

Yamamoto, S.; Egashira, N. Pathological mechanisms of bortezomib-induced peripheral neuropathy. Int. J. Mol. Sci., 2021, 22(2), 888.
[http://dx.doi.org/10.3390/ijms22020888] [PMID: 33477371]

Tanimukai, H.; Kanayama, D.; Omi, T.; Takeda, M.; Kudo, T. Paclitaxel induces neurotoxicity through endoplasmic reticulum stress. Biochem. Biophys. Res. Commun., 2013, 437(1), 151-155.
[http://dx.doi.org/10.1016/j.bbrc.2013.06.057] [PMID: 23806691]

Bezu, L.; Sauvat, A.; Humeau, J.; Gomes-da-Silva, L.C.; Iribarren, K.; Forveille, S.; Garcia, P.; Zhao, L.; Liu, P.; Zitvogel, L.; Senovilla, L.; Kepp, O.; Kroemer, G. eIF2α phosphorylation is pathognomonic for immunogenic cell death. Cell Death Differ., 2018, 25(8), 1375-1393.
[http://dx.doi.org/10.1038/s41418-017-0044-9] [PMID: 29358668]

Panaretakis, T.; Kepp, O.; Brockmeier, U.; Tesniere, A.; Bjorklund, A.C.; Chapman, D.C.; Durchschlag, M.; Joza, N.; Pierron, G.; van Endert, P.; Yuan, J.; Zitvogel, L.; Madeo, F.; Williams, D.B.; Kroemer, G. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J., 2009, 28(5), 578-590.
[http://dx.doi.org/10.1038/emboj.2009.1] [PMID: 19165151]

Kepp, O.; Galluzzi, L.; Giordanetto, F.; Tesniere, A.; Vitale, I.; Martins, I.; Schlemmer, F.; Adjemian, S.; Zitvogel, L.; Kroemer, G. Disruption of the PP1/GADD34 complex induces calreticulin exposure. Cell Cycle, 2009, 8(23), 3971-3977.
[http://dx.doi.org/10.4161/cc.8.23.10191] [PMID: 19901557]

Xiang, Y.; Chen, L.; Liu, C.; Yi, X.; Li, L.; Huang, Y. Redirecting chemotherapeutics to the endoplasmic reticulum increases tumor immunogenicity and potentiates anti-PD-L1 therapy. Small, 2022, 18(6), 2104591.
[http://dx.doi.org/10.1002/smll.202104591] [PMID: 34859582]

Shen, X.; Deng, Y.; Chen, L.; Liu, C.; Li, L.; Huang, Y. Modulation of autophagy direction to enhance antitumor effect of endoplasmic-reticulum-targeted therapy: Left or right? Adv. Sci., 2023, 10(23), 2301434.
[http://dx.doi.org/10.1002/advs.202301434] [PMID: 37290058]

Jeon, J.; Yoon, B.; Dey, A.; Song, S.H.; Li, Y.; Joo, H.; Park, J.H. Self-immolative polymer-based immunogenic cell death inducer for regulation of redox homeostasis. Biomaterials, 2023, 295, 122064.
[http://dx.doi.org/10.1016/j.biomaterials.2023.122064] [PMID: 36827894]

Hartmann, L.; Osen, W.; Eichmüller, O.L.; Kordaß, T.; Furkel, J.; Dickes, E.; Reid, C.; Debus, J.; Brons, S.; Abdollahi, A.; Moustafa, M.; Rieken, S.; Eichmüller, S.B. Carbon ion irradiation plus CTLA4 blockade elicits therapeutic immune responses in a murine tumor model. Cancer Lett., 2022, 550, 215928.
[http://dx.doi.org/10.1016/j.canlet.2022.215928] [PMID: 36183858]

Chaurasia, M.; Gupta, S.; Das, A.; Dwarakanath, B.S.; Simonsen, A.; Sharma, K. Radiation induces EIF2AK3/PERK and ERN1/IRE1 mediated pro-survival autophagy. Autophagy, 2019, 15(8), 1391-1406.
[http://dx.doi.org/10.1080/15548627.2019.1582973] [PMID: 30773986]

Pang, X.L.; He, G.; Liu, Y.B.; Wang, Y.; Zhang, B. Endoplasmic reticulum stress sensitizes human esophageal cancer cell to radiation. World J. Gastroenterol., 2013, 19(11), 1736-1748.
[http://dx.doi.org/10.3748/wjg.v19.i11.1736] [PMID: 23555162]

Xiu, Z.; Sun, T.; Yang, Y.; He, Y.; Yang, S.; Xue, X.; Yang, W. Curcumin enhanced ionizing radiation-induced immunogenic cell death in glioma cells through endoplasmic reticulum stress signaling pathways. Oxid. Med. Cell. Longev., 2022, 2022, 1-17.
[http://dx.doi.org/10.1155/2022/5424411] [PMID: 36238646]

Zheng, X.; Jin, X.; Li, F.; Liu, X.; Liu, Y.; Ye, F.; Li, P.; Zhao, T.; Li, Q. Inhibiting autophagy with chloroquine enhances the anti-tumor effect of high-LET carbon ions via ER stress-related apoptosis. Med. Oncol., 2017, 34(2), 25.
[http://dx.doi.org/10.1007/s12032-017-0883-8] [PMID: 28070729]

Yang, P.; Feng, X.; Li, J.; Zhang, T.; Sheng, C.; Zhang, L.; Hua, J.; Wei, W.; Ding, N.; He, J.; Zhang, Y.; Wang, J.; Zhou, H. Ionizing radiation downregulates estradiol synthesis via endoplasmic reticulum stress and inhibits the proliferation of estrogen receptor- positive breast cancer cells. Cell Death Dis., 2021, 12(11), 1029.
[http://dx.doi.org/10.1038/s41419-021-04328-w] [PMID: 34716300]

Feng, X.P.; Yi, H.; Li, M.Y.; Li, X.H.; Yi, B.; Zhang, P.F.; Li, C.; Peng, F.; Tang, C.E.; Li, J.L.; Chen, Z.C.; Xiao, Z.Q. Identification of biomarkers for predicting nasopharyngeal carcinoma response to radiotherapy by proteomics. Cancer Res., 2010, 70(9), 3450-3462.
[http://dx.doi.org/10.1158/0008-5472.CAN-09-4099] [PMID: 20406978]

Biau, J.; Chautard, E.; De Koning, L.; Court, F.; Pereira, B.; Verrelle, P.; Dutreix, M. Predictive biomarkers of resistance to hypofractionated radiotherapy in high grade glioma. Radiat. Oncol., 2017, 12(1), 123.
[http://dx.doi.org/10.1186/s13014-017-0858-0] [PMID: 28754127]

Wang, K.; Klionsky, D.J. Mitochondria removal by autophagy. Autophagy, 2011, 7(3), 297-300.
[http://dx.doi.org/10.4161/auto.7.3.14502] [PMID: 21252623]

Zheng, X.; Jin, X.; Liu, X.; Liu, B.; Li, P.; Ye, F.; Zhao, T.; Chen, W.; Li, Q. Inhibition of endoplasmic reticulum stress-induced autophagy promotes the killing effect of X-rays on sarcoma in mice. Biochem. Biophys. Res. Commun., 2020, 522(3), 612-617.
[http://dx.doi.org/10.1016/j.bbrc.2019.11.160] [PMID: 31785812]

Ramirez, M.U.; Hernandez, S.R.; Soto-Pantoja, D.R.; Cook, K.L. Endoplasmic reticulum stress pathway, the unfolded protein response, modulates immune function in the tumor microenvironment to impact tumor progression and therapeutic response. Int. J. Mol. Sci., 2019, 21(1), 169.
[http://dx.doi.org/10.3390/ijms21010169] [PMID: 31881743]

Li, A.; Song, N.J.; Riesenberg, B.P.; Li, Z. The emerging roles of endoplasmic reticulum stress in balancing immunity and tolerance in health and diseases: Mechanisms and opportunities. Front. Immunol., 2020, 10, 3154.
[http://dx.doi.org/10.3389/fimmu.2019.03154] [PMID: 32117210]

Xiong, X.; Huang, K.B.; Wang, Y.; Cao, B.; Luo, Y.; Chen, H.; Yang, Y.; Long, Y.; Liu, M.; Chan, A.S.C.; Liang, H.; Zou, T. Target profiling of an iridium(III)-based immunogenic cell death inducer unveils the engagement of unfolded protein response regulator BiP. J. Am. Chem. Soc., 2022, 144(23), 10407-10416.
[http://dx.doi.org/10.1021/jacs.2c02435] [PMID: 35658433]

Wu, J.; Rutkowski, D.T.; Dubois, M.; Swathirajan, J.; Saunders, T.; Wang, J.; Song, B.; Yau, G.D.Y.; Kaufman, R.J. ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev. Cell, 2007, 13(3), 351-364.
[http://dx.doi.org/10.1016/j.devcel.2007.07.005] [PMID: 17765679]

Jiang, M.; Jia, K.; Wang, L.; Li, W.; Chen, B.; Liu, Y.; Wang, H.; Zhao, S.; He, Y.; Zhou, C. Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy. Acta Pharm. Sin. B, 2021, 11(10), 2983-2994.
[http://dx.doi.org/10.1016/j.apsb.2021.01.003] [PMID: 34729299]

Welz, L.; Kakavand, N.; Hang, X.; Laue, G.; Ito, G.; Silva, M.G.; Plattner, C.; Mishra, N.; Tengen, F.; Ogris, C.; Jesinghaus, M.; Wottawa, F.; Arnold, P.; Kaikkonen, L.; Stengel, S.; Tran, F.; Das, S.; Kaser, A.; Trajanoski, Z.; Blumberg, R.; Roecken, C.; Saur, D.; Tschurtschenthaler, M.; Schreiber, S.; Rosenstiel, P.; Aden, K. Epithelial X-box binding protein 1 coordinates tumor protein p53-driven DNA damage responses and suppression of intestinal carcinogenesis. Gastroenterology, 2022, 162(1), 223-237.e11.
[http://dx.doi.org/10.1053/j.gastro.2021.09.057] [PMID: 34599932]

Zheng, Y.; Liu, P.; Wang, N.; Wang, S.; Yang, B.; Li, M.; Chen, J.; Situ, H.; Xie, M.; Lin, Y.; Wang, Z. Betulinic acid suppresses breast cancer metastasis by targeting grp78-mediated glycolysis and er stress apoptotic pathway. Oxid. Med. Cell. Longev., 2019, 2019, 1-15.
[http://dx.doi.org/10.1155/2019/8781690] [PMID: 31531187]

Féral, K.; Jaud, M.; Philippe, C.; Di Bella, D.; Pyronnet, S.; Rouault-Pierre, K.; Mazzolini, L.; Touriol, C. ER stress and unfolded protein response in leukemia: Friend, foe, or both? Biomolecules, 2021, 11(2), 199.
[http://dx.doi.org/10.3390/biom11020199] [PMID: 33573353]

Brewer, J.W.; Diehl, J.A. PERK mediates cell-cycle exit during the mammalian unfolded protein response. Proc. Natl. Acad. Sci., 2000, 97(23), 12625-12630.
[http://dx.doi.org/10.1073/pnas.220247197] [PMID: 11035797]

Deng, Z.; Sun, R.; Han, X.; Zhang, Y.; Zhou, Y.; Shan, Y.; Xu, J.; Li, X.; He, F.; Fang, W. Porcine circovirus 2 activates the PERK-reactive oxygen species axis to induce p53 phosphorylation with subsequent cell cycle arrest at S phase in favor of its replication. J. Virol., 2022, 96(22), e01274-22.
[http://dx.doi.org/10.1128/jvi.01274-22] [PMID: 36300938]

Rojas-Rivera, D.; Delvaeye, T.; Roelandt, R.; Nerinckx, W.; Augustyns, K.; Vandenabeele, P.; Bertrand, M.J.M. When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157. Cell Death Differ., 2017, 24(6), 1100-1110.
[http://dx.doi.org/10.1038/cdd.2017.58] [PMID: 28452996]

Wang, Z.; Yin, F.; Xu, J.; Zhang, T.; Wang, G.; Mao, M.; Wang, Z.; Sun, W.; Han, J.; Yang, M.; Jiang, Y.; Hua, Y.; Cai, Z. CYT997(Lexibulin) induces apoptosis and autophagy through the activation of mutually reinforced ER stress and ROS in osteosarcoma. J. Exp. Clin. Cancer Res., 2019, 38(1), 44.
[http://dx.doi.org/10.1186/s13046-019-1047-9] [PMID: 30704503]

Wei, W.; Li, Y.; Wang, C.; Gao, S.; Zhao, Y.; Yang, Z.; Wang, H.; Gao, Z.; Jiang, Y.; He, Y.; Zhao, L.; Gao, H.; Yao, X.; Hu, Y. Diterpenoid Vinigrol specifically activates ATF4/DDIT3-mediated PERK arm of unfolded protein response to drive non-apoptotic death of breast cancer cells. Pharmacol. Res., 2022, 182, 106285.
[http://dx.doi.org/10.1016/j.phrs.2022.106285] [PMID: 35662627]

Nguyen, H.G.; Conn, C.S.; Kye, Y.; Xue, L.; Forester, C.M.; Cowan, J.E.; Hsieh, A.C.; Cunningham, J.T.; Truillet, C.; Tameire, F.; Evans, M.J.; Evans, C.P.; Yang, J.C.; Hann, B.; Koumenis, C.; Walter, P.; Carroll, P.R.; Ruggero, D. Development of a stress response therapy targeting aggressive prostate cancer. Sci. Transl. Med., 2018, 10(439), eaar2036.
[http://dx.doi.org/10.1126/scitranslmed.aar2036] [PMID: 29720449]

Urra, H.; Dufey, E.; Avril, T.; Chevet, E.; Hetz, C. Endoplasmic reticulum stress and the hallmarks of cancer. Trends Cancer, 2016, 2(5), 252-262.
[http://dx.doi.org/10.1016/j.trecan.2016.03.007] [PMID: 28741511]

Wheeler, M.A.; Jaronen, M.; Covacu, R.; Zandee, S.E.J.; Scalisi, G.; Rothhammer, V.; Tjon, E.C.; Chao, C.C.; Kenison, J.E.; Blain, M.; Rao, V.T.S.; Hewson, P.; Barroso, A.; Gutiérrez-Vázquez, C.; Prat, A.; Antel, J.P.; Hauser, R.; Quintana, F.J. Environmental control of astrocyte pathogenic activities in CNS Inflammation. Cell, 2019, 176(3), 581-596.e18.
[http://dx.doi.org/10.1016/j.cell.2018.12.012] [PMID: 30661753]

Lin, J.; Liu, H.; Fukumoto, T.; Zundell, J.; Yan, Q.; Tang, C.H.A.; Wu, S.; Zhou, W.; Guo, D.; Karakashev, S.; Hu, C.C.A.; Sarma, K.; Kossenkov, A.V.; Zhang, R. Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer. Nat. Commun., 2021, 12(1), 5321.
[http://dx.doi.org/10.1038/s41467-021-25684-3] [PMID: 34493732]

Gao, Q.; Li, X.; Xu, Y.; Zhang, J.; Rong, S.; Qin, Y.; Fang, J. IRE1α-targeting downregulates ABC transporters and overcomes drug resistance of colon cancer cells. Cancer Lett., 2020, 476, 67-74.
[http://dx.doi.org/10.1016/j.canlet.2020.02.007] [PMID: 32061752]

Xiao, R.; You, L.; Zhang, L.; Guo, X.; Guo, E.; Zhao, F.; Yang, B.; Li, X.; Fu, Y.; Lu, F.; Wang, Z.; Liu, C.; Peng, W.; Li, W.; Yang, X.; Dou, Y.; Liu, J.; Wang, W.; Qin, T.; Cui, Y.; Zhang, X.; Li, F.; Jin, Y.; Zeng, Q.; Wang, B.; Mills, G.B.; Chen, G.; Sheng, X.; Sun, C. Inhibiting the IRE1 α axis of the unfolded protein response enhances the antitumor effect of AZD1775 in TP53 mutant ovarian cancer. Adv. Sci., 2022, 9(21), 2105469.
[http://dx.doi.org/10.1002/advs.202105469] [PMID: 35619328]

Liang, Y.; Liang, L.; Liu, Z.; Wang, Y.; Dong, X.; Qu, L.; Gou, R.; Wang, Y.; Wang, Q.; Liu, Z.; Tang, L. Inhibition of IRE1/JNK pathway in HK-2 cells subjected to hypoxia-reoxygenation attenuates mesangial cells-derived extracellular matrix production. J. Cell. Mol. Med., 2020, 24(22), 13408-13420.
[http://dx.doi.org/10.1111/jcmm.15964] [PMID: 33043579]

Rufo, N.; Korovesis, D.; Van Eygen, S.; Derua, R.; Garg, A.D.; Finotello, F.; Vara-Perez, M.; Rožanc, J.; Dewaele, M.; de Witte, P.A.; Alexopoulos, L.G.; Janssens, S.; Sinkkonen, L.; Sauter, T.; Verhelst, S.H.L.; Agostinis, P. Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting. Cell Death Differ., 2022, 29(1), 230-245.
[http://dx.doi.org/10.1038/s41418-021-00853-5] [PMID: 34453119]

Sheng, X.; Nenseth, H.Z.; Qu, S.; Kuzu, O.F.; Frahnow, T.; Simon, L.; Greene, S.; Zeng, Q.; Fazli, L.; Rennie, P.S.; Mills, I.G.; Danielsen, H.; Theis, F.; Patterson, J.B.; Jin, Y.; Saatcioglu, F. IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling. Nat. Commun., 2019, 10(1), 323.
[http://dx.doi.org/10.1038/s41467-018-08152-3] [PMID: 30679434]

Kny, M.; Fielitz, J. Hidden Agenda - the involvement of endoplasmic reticulum stress and unfolded protein response in inflammation-induced muscle wasting. Front. Immunol., 2022, 13, 878755.
[http://dx.doi.org/10.3389/fimmu.2022.878755] [PMID: 35615361]

Di Conza, G.; Ho, P.C. ER stress responses: An emerging modulator for innate immunity. Cells, 2020, 9(3), 695.
[http://dx.doi.org/10.3390/cells9030695] [PMID: 32178254]

Van Campenhout, S.; Tilleman, L.; Lefere, S.; Vandierendonck, A.; Raevens, S.; Verhelst, X.; Geerts, A.; Van Nieuwerburgh, F.; Van Vlierberghe, H.; Devisscher, L. Myeloid-specific IRE1alpha deletion reduces tumour development in a diabetic, non-alcoholic steatohepatitis-induced hepatocellular carcinoma mouse model. Metabolism, 2020, 107, 154220.
[http://dx.doi.org/10.1016/j.metabol.2020.154220] [PMID: 32243868]

Gupta, S.; McGrath, B.; Cavener, D.R. PERK regulates the proliferation and development of insulin-secreting beta-cell tumors in the endocrine pancreas of mice. PLoS One, 2009, 4(11), e8008.
[http://dx.doi.org/10.1371/journal.pone.0008008] [PMID: 19956728]

Sunami, Y.; Ringelhan, M.; Kokai, E.; Lu, M.; O’Connor, T.; Lorentzen, A.; Weber, A.; Rodewald, A.K.; Müllhaupt, B.; Terracciano, L.; Gul, S.; Wissel, S.; Leithäuser, F.; Krappmann, D.; Riedl, P.; Hartmann, D.; Schirmbeck, R.; Strnad, P.; Hüser, N.; Kleeff, J.; Friess, H.; Schmid, R.M.; Geisler, F.; Wirth, T.; Heikenwalder, M. Canonical NF-κB signaling in hepatocytes acts as a tumor-suppressor in hepatitis B virus surface antigen-driven hepatocellular carcinoma by controlling the unfolded protein response. Hepatology, 2016, 63(5), 1592-1607.
[http://dx.doi.org/10.1002/hep.28435] [PMID: 26892811]

Hillary, R.F.; FitzGerald, U. A lifetime of stress: ATF6 in development and homeostasis. J. Biomed. Sci., 2018, 25(1), 48.
[http://dx.doi.org/10.1186/s12929-018-0453-1] [PMID: 29801500]

Harapas, C.R.; Idiiatullina, E.; Al-Azab, M.; Hrovat-Schaale, K.; Reygaerts, T.; Steiner, A.; Laohamonthonkul, P.; Davidson, S.; Yu, C.H.; Booty, L.; Masters, S.L. Organellar homeostasis and innate immune sensing. Nat. Rev. Immunol., 2022, 22(9), 535-549.
[http://dx.doi.org/10.1038/s41577-022-00682-8] [PMID: 35197578]

Rashid, F.; Dzakah, E.E.; Wang, H.; Tang, S. The ORF8 protein of SARS-CoV-2 induced endoplasmic reticulum stress and mediated immune evasion by antagonizing production of interferon beta. Virus Res., 2021, 296, 198350.
[http://dx.doi.org/10.1016/j.virusres.2021.198350] [PMID: 33626380]

Iida, J.; Ishii, S.; Nakajima, Y.; Sessler, D.I.; Teramae, H.; Kageyama, K.; Maeda, S.; Anada, N.; Shibasaki, M.; Sawa, T.; Nakayama, Y. Hyperglycaemia augments lipopolysaccharide-induced reduction in rat and human macrophage phagocytosis via the endoplasmic stress-C/EBP homologous protein pathway. Br. J. Anaesth., 2019, 123(1), 51-59.
[http://dx.doi.org/10.1016/j.bja.2019.03.040] [PMID: 31084986]

Stadhouders, R.; Lubberts, E.; Hendriks, R.W. A cellular and molecular view of T helper 17 cell plasticity in autoimmunity. J. Autoimmun., 2018, 87, 1-15.
[http://dx.doi.org/10.1016/j.jaut.2017.12.007] [PMID: 29275836]

Wu, H.; Zheng, S.; Zhang, J.; Xu, S.; Miao, Z. Cadmium induces endoplasmic reticulum stress-mediated apoptosis in pig pancreas via the increase of Th1 cells. Toxicology, 2021, 457, 152790.
[http://dx.doi.org/10.1016/j.tox.2021.152790] [PMID: 33891997]

Lu, G.; Li, Q.; Liu, J.; Jia, Y.; Tang, J.; Zhang, X. Inhibition of endoplasmic reticulum stress and the downstream pathways protects CD4⁺ T cells against apoptosis and immune dysregulation in sepsis. IUBMB Life, 2022, 74(11), 1070-1080.
[http://dx.doi.org/10.1002/iub.2666] [PMID: 35859520]

So, J.S. Roles of endoplasmic reticulum stress in immune responses. Mol. Cells, 2018, 41(8), 705-716.
[PMID: 30078231]

Thaxton, J.E.; Wallace, C.; Riesenberg, B.; Zhang, Y.; Paulos, C.M.; Beeson, C.C.; Liu, B.; Li, Z. Modulation of endoplasmic reticulum stress controls CD4⁺ T-cell activation and antitumor function. Cancer Immunol. Res., 2017, 5(8), 666-675.
[http://dx.doi.org/10.1158/2326-6066.CIR-17-0081] [PMID: 28642246]

Xu, Y.; Melo-Cardenas, J.; Zhang, Y.; Gau, I.; Wei, J.; Montauti, E.; Zhang, Y.; Gao, B.; Jin, H.; Sun, Z.; Lee, S.M.; Fang, D. The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine–induced ER stress response. JCI Insight, 2019, 4(5), e121887.
[http://dx.doi.org/10.1172/jci.insight.121887] [PMID: 30843874]

Cao, Y.; Trillo-Tinoco, J.; Sierra, R.A.; Anadon, C.; Dai, W.; Mohamed, E.; Cen, L.; Costich, T.L.; Magliocco, A.; Marchion, D.; Klar, R.; Michel, S.; Jaschinski, F.; Reich, R.R.; Mehrotra, S.; Cubillos-Ruiz, J.R.; Munn, D.H.; Conejo-Garcia, J.R.; Rodriguez, P.C. ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. Nat. Commun., 2019, 10(1), 1280.
[http://dx.doi.org/10.1038/s41467-019-09263-1] [PMID: 30894532]

Thevenot, P.T.; Sierra, R.A.; Raber, P.L.; Al-Khami, A.A.; Trillo-Tinoco, J.; Zarreii, P.; Ochoa, A.C.; Cui, Y.; Del Valle, L.; Rodriguez, P.C. The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors. Immunity, 2014, 41(3), 389-401.
[http://dx.doi.org/10.1016/j.immuni.2014.08.015] [PMID: 25238096]

Barrow, A.D.; Edeling, M.A.; Trifonov, V.; Luo, J.; Goyal, P.; Bohl, B.; Bando, J.K.; Kim, A.H.; Walker, J.; Andahazy, M.; Bugatti, M.; Melocchi, L.; Vermi, W.; Fremont, D.H.; Cox, S.; Cella, M.; Schmedt, C.; Colonna, M. Natural killer cells control tumor growth by sensing a growth factor. Cell, 2018, 172(3), 534-548.e19.
[http://dx.doi.org/10.1016/j.cell.2017.11.037] [PMID: 29275861]

Van Elssen, C.H.M.J.; Ciurea, S.O. NK cell alloreactivity in acute myeloid leukemia in the post-transplant cyclophosphamide era. Am. J. Hematol., 2020, 95(12), 1590-1598.
[http://dx.doi.org/10.1002/ajh.25983] [PMID: 32857869]

Zakiryanova, G.; Kustova, E.; Urazalieva, N.; Baimuchametov, E.; Nakisbekov, N.; Shurin, M. Abnormal expression of c-Myc oncogene in NK cells in patients with cancer. Int. J. Mol. Sci., 2019, 20(3), 756.
[http://dx.doi.org/10.3390/ijms20030756] [PMID: 30754645]

Wang, Y.; Zhang, Y.; Yi, P.; Dong, W.; Nalin, A.P.; Zhang, J.; Zhu, Z.; Chen, L.; Benson, D.M.; Mundy-Bosse, B.L.; Freud, A.G.; Caligiuri, M.A.; Yu, J. The IL-15–AKT–XBP1s signaling pathway contributes to effector functions and survival in human NK cells. Nat. Immunol., 2019, 20(1), 10-17.
[http://dx.doi.org/10.1038/s41590-018-0265-1] [PMID: 30538328]

Manoury, B.; Maisonneuve, L.; Podsypanina, K. The role of endoplasmic reticulum stress in the MHC class I antigen presentation pathway of dendritic cells. Mol. Immunol., 2022, 144, 44-48.
[http://dx.doi.org/10.1016/j.molimm.2022.02.007] [PMID: 35184022]

Mogilenko, D.A.; Haas, J.T.; L’homme, L.; Fleury, S.; Quemener, S.; Levavasseur, M.; Becquart, C.; Wartelle, J.; Bogomolova, A.; Pineau, L.; Molendi-Coste, O.; Lancel, S.; Dehondt, H.; Gheeraert, C.; Melchior, A.; Dewas, C.; Nikitin, A.; Pic, S.; Rabhi, N.; Annicotte, J.S.; Oyadomari, S.; Velasco-Hernandez, T.; Cammenga, J.; Foretz, M.; Viollet, B.; Vukovic, M.; Villacreces, A.; Kranc, K.; Carmeliet, P.; Marot, G.; Boulter, A.; Tavernier, S.; Berod, L.; Longhi, M.P.; Paget, C.; Janssens, S.; Staumont-Sallé, D.; Aksoy, E.; Staels, B.; Dombrowicz, D. Metabolic and innate immune cues merge into a specific inflammatory response via the UPR. Cell, 2019, 177(5), 1201-1216.e19.
[http://dx.doi.org/10.1016/j.cell.2019.03.018] [PMID: 31031005]

Cubillos-Ruiz, J.R.; Bettigole, S.E.; Glimcher, L.H. Molecular pathways: Immunosuppressive roles of IRE1α-XBP1 signaling in dendritic cells of the tumor microenvironment. Clin. Cancer Res., 2016, 22(9), 2121-2126.
[http://dx.doi.org/10.1158/1078-0432.CCR-15-1570] [PMID: 26979393]

Tian, S.; Liu, Z.; Donahue, C.; Falo, L.D., Jr; You, Z. Genetic targeting of the active transcription factor XBP1s to dendritic cells potentiates vaccine-induced prophylactic and therapeutic antitumor immunity. Mol. Ther., 2012, 20(2), 432-442.
[http://dx.doi.org/10.1038/mt.2011.183] [PMID: 21934655]

Cubillos-Ruiz, J.R.; Silberman, P.C.; Rutkowski, M.R.; Chopra, S.; Perales-Puchalt, A.; Song, M.; Zhang, S.; Bettigole, S.E.; Gupta, D.; Holcomb, K.; Ellenson, L.H.; Caputo, T.; Lee, A.H.; Conejo-Garcia, J.R.; Glimcher, L.H. ER stress sensor XBP1 controls anti-tumor immunity by disrupting dendritic cell homeostasis. Cell, 2015, 161(7), 1527-1538.
[http://dx.doi.org/10.1016/j.cell.2015.05.025] [PMID: 26073941]

Tognarelli, E.I.; Retamal-Díaz, A.; Farías, M.A.; Duarte, L.F.; Palomino, T.F.; Ibañez, F.J.; Riedel, C.A.; Kalergis, A.M.; Bueno, S.M.; González, P.A. Pharmacological inhibition of IRE-1 alpha activity in herpes simplex virus type 1 and type 2-infected dendritic cells enhances t cell activation. Front. Immunol., 2022, 12, 764861.
[http://dx.doi.org/10.3389/fimmu.2021.764861] [PMID: 35069537]

Lu, C.; Liu, Z.; Klement, J.D.; Yang, D.; Merting, A.D.; Poschel, D.; Albers, T.; Waller, J.L.; Shi, H.; Liu, K. WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape. J. Immunother. Cancer, 2021, 9(7), e002624.
[http://dx.doi.org/10.1136/jitc-2021-002624] [PMID: 34326167]

Song, D.; Zhou, Z.; Zhang, D.; Wu, J.; Hao, Q.; Zhao, L.; Ren, H.; Zhang, B. Identification of an endoplasmic reticulum stress-related gene signature to evaluate the immune status and predict the prognosis of hepatocellular carcinoma. Front. Genet., 2022, 13, 850200.
[http://dx.doi.org/10.3389/fgene.2022.850200] [PMID: 35711939]

Liu, J.; Fan, L.; Yu, H.; Zhang, J.; He, Y.; Feng, D.; Wang, F.; Li, X.; Liu, Q.; Li, Y.; Guo, Z.; Gao, B.; Wei, W.; Wang, H.; Sun, G. Endoplasmic reticulum stress causes liver cancer cells to release exosomal miR-23a-3p and up-regulate programmed death ligand 1 expression in macrophages. Hepatology, 2019, 70(1), 241-258.
[http://dx.doi.org/10.1002/hep.30607] [PMID: 30854665]

Chen, Z.; Wu, Q.; Ding, Y.; Zhou, W.; Liu, R.; Chen, H.; Zhou, J.; Feng, J.; Chen, C. YD277 suppresses triple-negative breast cancer partially through activating the endoplasmic reticulum stress pathway. Theranostics, 2017, 7(8), 2339-2349.
[http://dx.doi.org/10.7150/thno.17555] [PMID: 28740556]

Vieri, M.; Preisinger, C.; Schemionek, M.; Salimi, A.; Patterson, J.B.; Samali, A.; Brümmendorf, T.H.; Appelmann, I.; Kharabi Masouleh, B. Targeting of BCR-ABL1 and IRE1α induces synthetic lethality in Philadelphia-positive acute lymphoblastic leukemia. Carcinogenesis, 2021, 42(2), 272-284.
[http://dx.doi.org/10.1093/carcin/bgaa095] [PMID: 32915195]

Papandreou, I.; Denko, N.C.; Olson, M.; Van Melckebeke, H.; Lust, S.; Tam, A.; Solow-Cordero, D.E.; Bouley, D.M.; Offner, F.; Niwa, M.; Koong, A.C. Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood, 2011, 117(4), 1311-1314.
[http://dx.doi.org/10.1182/blood-2010-08-303099] [PMID: 21081713]

Jain, B.P. An overview of unfolded protein response signaling and its role in cancer. Cancer Biother. Radiopharm., 2017, 32(8), 275-281.
[http://dx.doi.org/10.1089/cbr.2017.2309] [PMID: 29053418]

Brewer, J.W.; Hendershot, L.M.; Sherr, C.J.; Diehl, J.A. Mammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression. Proc. Natl. Acad. Sci. USA, 1999, 96(15), 8505-8510.
[http://dx.doi.org/10.1073/pnas.96.15.8505] [PMID: 10411905]

Christianson, J.C.; Ye, Y. Cleaning up in the endoplasmic reticulum: Ubiquitin in charge. Nat. Struct. Mol. Biol., 2014, 21(4), 325-335.
[http://dx.doi.org/10.1038/nsmb.2793] [PMID: 24699081]

Wu, Z.; Wang, C.; Zhang, Z.; Liu, W.; Xu, H.; Wang, H.; Wang, Y.; Zhang, W.; Wang, S.L. High expression of derlin-1 is associated with the malignancy of bladder cancer in a chinese han population. PLoS One, 2016, 11(12), e0168351.
[http://dx.doi.org/10.1371/journal.pone.0168351] [PMID: 27977784]

Wu, C.H.; Silvers, C.R.; Messing, E.M.; Lee, Y.F. Bladder cancer extracellular vesicles drive tumorigenesis by inducing the unfolded protein response in endoplasmic reticulum of nonmalignant cells. J. Biol. Chem., 2019, 294(9), 3207-3218.
[http://dx.doi.org/10.1074/jbc.RA118.006682] [PMID: 30593508]

Yan, X.; Chen, M.; Xiao, C.; Fu, J.; Sun, X.; Hu, Z.; Zhou, H. Effect of unfolded protein response on the immune infiltration and prognosis of transitional cell bladder cancer. Ann. Med., 2021, 53(1), 1049-1059.
[http://dx.doi.org/10.1080/07853890.2021.1918346] [PMID: 34187252]

Zhang, H.H.; Li, C.; Ren, J.W.; Liu, L.; Du, X.H.; Gao, J.; Liu, T.; Li, S.Z. OTUB1 facilitates bladder cancer progression by stabilizing ATF6 in response to endoplasmic reticulum stress. Cancer Sci., 2021, 112(6), 2199-2209.
[http://dx.doi.org/10.1111/cas.14876] [PMID: 33686769]

Wong, R.S.Y. Apoptosis in cancer: From pathogenesis to treatment. J. Exp. Clin. Cancer Res., 2011, 30(1), 87.
[http://dx.doi.org/10.1186/1756-9966-30-87] [PMID: 21943236]

Liu, Z.; Gu, S.; Lu, T.; Wu, K.; Li, L.; Dong, C.; Zhou, Y. IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress. J. Exp. Clin. Cancer Res., 2020, 39(1), 144.
[http://dx.doi.org/10.1186/s13046-020-01646-3] [PMID: 32727517]

Yin, X.M. Signal transduction mediated by Bid, a pro-death Bcl-2 family proteins, connects the death receptor and mitochondria apoptosis pathways. Cell Res., 2000, 10(3), 161-167.
[http://dx.doi.org/10.1038/sj.cr.7290045] [PMID: 11032168]

Wong, B.S.; Hsiao, Y.C.; Lin, T.W.; Chen, K.S.; Chen, P.N.; Kuo, W.H.; Chu, S.C.; Hsieh, Y.S. The in vitro and in vivo apoptotic effects of Mahonia oiwakensis on human lung cancer cells. Chem. Biol. Interact., 2009, 180(2), 165-174.
[http://dx.doi.org/10.1016/j.cbi.2009.02.011] [PMID: 19497414]

Sato, A.; Asano, T.; Okubo, K.; Isono, M.; Asano, T. Nelfinavir and ritonavir kill bladder cancer cells synergistically by inducing endoplasmic reticulum stress. Oncol. Res., 2018, 26(2), 323-332.
[http://dx.doi.org/10.3727/096504017X14957929842972] [PMID: 28560953]

Xu, Y.; Tong, Y.; Ying, J.; Lei, Z.; Wan, L.; Zhu, X.; Ye, F.; Mao, P.; Wu, X.; Pan, R.; Peng, B.; Liu, Y.; Zhu, J. Chrysin induces cell growth arrest, apoptosis, and ER stress and inhibits the activation of STAT3 through the generation of ROS in bladder cancer cells. Oncol. Lett., 2018, 15(6), 9117-9125.
[http://dx.doi.org/10.3892/ol.2018.8522] [PMID: 29805643]

Zhang, M.; Du, H.; Huang, Z.; Zhang, P.; Yue, Y.; Wang, W.; Liu, W.; Zeng, J.; Ma, J.; Chen, G.; Wang, X.; Fan, J. Thymoquinone induces apoptosis in bladder cancer cell via endoplasmic reticulum stress-dependent mitochondrial pathway. Chem. Biol. Interact., 2018, 292, 65-75.
[http://dx.doi.org/10.1016/j.cbi.2018.06.013] [PMID: 29981725]

Wu, Y.J.; Su, T.R.; Dai, G.F.; Su, J.H.; Liu, C.I. Flaccidoxide-13-acetate-induced apoptosis in human bladder cancer cells is through activation of p38/JNK, mitochondrial dysfunction, and endoplasmic reticulum stress regulated pathway. Mar. Drugs, 2019, 17(5), 287.
[http://dx.doi.org/10.3390/md17050287] [PMID: 31086026]

Cui, J.; Sun, W.; Hao, X.; Wei, M.; Su, X.; Zhang, Y.; Su, L.; Liu, X. EHMT2 inhibitor BIX-01294 induces apoptosis through PMAIP1-USP9X-MCL1 axis in human bladder cancer cells. Cancer Cell Int., 2015, 15(1), 4.
[http://dx.doi.org/10.1186/s12935-014-0149-x] [PMID: 25685062]

Zhang, J.; Sun, A.; Xu, R.; Tao, X.; Dong, Y.; Lv, X.; Wei, D. Cell-penetrating and endoplasmic reticulum-locating TAT-IL-24-KDEL fusion protein induces tumor apoptosis. J. Cell. Physiol., 2016, 231(1), 84-93.
[http://dx.doi.org/10.1002/jcp.25054] [PMID: 26031207]

Xi, H.; Wang, S.; Wang, B.; Hong, X.; Liu, X.; Li, M.; Shen, R.; Dong, Q. The role of interaction between autophagy and apoptosis in tumorigenesis (Review). Oncol. Rep., 2022, 48(6), 208.
[http://dx.doi.org/10.3892/or.2022.8423] [PMID: 36222296]

Fernández, A.; Ordóñez, R.; Reiter, R.J.; González-Gallego, J.; Mauriz, J.L. Melatonin and endoplasmic reticulum stress: Relation to autophagy and apoptosis. J. Pineal Res., 2015, 59(3), 292-307.
[http://dx.doi.org/10.1111/jpi.12264] [PMID: 26201382]

Song, S.; Tan, J.; Miao, Y.; Li, M.; Zhang, Q. Crosstalk of autophagy and apoptosis: Involvement of the dual role of autophagy under ER stress. J. Cell. Physiol., 2017, 232(11), 2977-2984.
[http://dx.doi.org/10.1002/jcp.25785] [PMID: 28067409]

Cybulsky, A.V. Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases. Nat. Rev. Nephrol., 2017, 13(11), 681-696.
[http://dx.doi.org/10.1038/nrneph.2017.129] [PMID: 28970584]

Qi, Z.; Chen, L. Endoplasmic reticulum stress and autophagy. Adv. Exp. Med. Biol., 2019, 1206, 167-177.
[http://dx.doi.org/10.1007/978-981-15-0602-4_8] [PMID: 31776985]

Wadgaonkar, P.; Chen, F. Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis. Semin. Cancer Biol., 2021, 76, 258-266.
[http://dx.doi.org/10.1016/j.semcancer.2021.04.004] [PMID: 33836253]

Buytaert, E.; Matroule, J.Y.; Durinck, S.; Close, P.; Kocanova, S.; Vandenheede, J.R.; de Witte, P.A.; Piette, J.; Agostinis, P. Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells. Oncogene, 2008, 27(13), 1916-1929.
[http://dx.doi.org/10.1038/sj.onc.1210825] [PMID: 17952126]

Vallianou, N.G.; Evangelopoulos, A.; Schizas, N.; Kazazis, C. Potential anticancer properties and mechanisms of action of curcumin. Anticancer Res., 2015, 35(2), 645-651.
[PMID: 25667441]

Sang, J.; Gan, L.; Zou, M.F.; Lin, Z.J.; Fan, R.Z.; Huang, J.L.; Li, W.; Tang, G.H.; Yin, S. Jolkinolide B sensitizes bladder cancer to mTOR inhibitors via dual inhibition of Akt signaling and autophagy. Cancer Lett., 2022, 526, 352-362.
[http://dx.doi.org/10.1016/j.canlet.2021.11.014] [PMID: 34798195]

Lyu, L.; Xiang, W.; Zheng, F.; Huang, T.; Feng, Y.; Yuan, J.; Zhang, C. Significant prognostic value of the autophagy-related gene P4HB in bladder urothelial carcinoma. Front. Oncol., 2020, 10, 1613.
[http://dx.doi.org/10.3389/fonc.2020.01613] [PMID: 32903592]

Bednova, O.; Leyton, J.V. Targeted molecular therapeutics for bladder cancer—a new option beyond the mixed fortunes of immune checkpoint inhibitors? Int. J. Mol. Sci., 2020, 21(19), 7268.
[http://dx.doi.org/10.3390/ijms21197268] [PMID: 33019653]

Kong, Y.; Jiang, J.; Huang, Y.; Li, L.; Liu, X.; Jin, Z.; Wei, F.; Liu, X.; Zhang, S.; Duan, X.; Zhang, Y.; Tong, Q.; Chen, H. Endoplasmic reticulum stress in melanoma pathogenesis and resistance. Biomed. Pharmacother., 2022, 155, 113741.
[http://dx.doi.org/10.1016/j.biopha.2022.113741] [PMID: 36271543]

Prevo, R.; Tiwana, G.S.; Maughan, T.S.; Buffa, F.M.; McKenna, W.G.; Higgins, G.S. Depletion of signal recognition particle 72kDa increases radiosensitivity. Cancer Biol. Ther., 2017, 18(6), 425-432.
[http://dx.doi.org/10.1080/15384047.2017.1323587] [PMID: 28494188]

Wang, X.; Bai, Y.; Zhang, F.; Yang, Y.; Feng, D.; Li, A.; Yang, Z.; Li, D.; Tang, Y.; Wei, X.; Wei, W.; Han, P. Targeted inhibition of P4HB promotes cell sensitivity to gemcitabine in urothelial carcinoma of the bladder. OncoTargets Ther., 2020, 13, 9543-9558.
[http://dx.doi.org/10.2147/OTT.S267734] [PMID: 33061438]

Su, S-F.; Chang, Y-W.; Andreu-Vieyra, C.; Fang, J.Y.; Yang, Z.; Han, B.; Lee, A.S.; Liang, G. miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. Oncogene, 2013, 32(39), 4694-4701.
[http://dx.doi.org/10.1038/onc.2012.483] [PMID: 23085757]

Whang, Y.M.; Yoon, D.H.; Hwang, G.Y.; Yoon, H.; Park, S.I.; Choi, Y.W.; Chang, I.H. Liposome-encapsulated bacillus calmette–guérin cell wall skeleton enhances antitumor efficiency for bladder cancer in vitro and in vivo via induction of AMP-activated protein kinase. Cancers, 2020, 12(12), 3679.
[http://dx.doi.org/10.3390/cancers12123679] [PMID: 33302414]

Tcyganov, E.N.; Hanabuchi, S.; Hashimoto, A.; Campbell, D.; Kar, G.; Slidel, T.W.F.; Cayatte, C.; Landry, A.; Pilataxi, F.; Hayes, S.; Dougherty, B.; Hicks, K.C.; Mulgrew, K.; Tang, C.H.A.; Hu, C.C.A.; Guo, W.; Grivennikov, S.; Ali, M.A.A.; Beltra, J.C.; Wherry, E.J.; Nefedova, Y.; Gabrilovich, D.I. Distinct mechanisms govern populations of myeloid-derived suppressor cells in chronic viral infection and cancer. J. Clin. Invest., 2021, 131(16), e145971.
[http://dx.doi.org/10.1172/JCI145971] [PMID: 34228641]

Iurlaro, R.; Muñoz-Pinedo, C. Cell death induced by endoplasmic reticulum stress. FEBS J., 2016, 283(14), 2640-2652.
[http://dx.doi.org/10.1111/febs.13598] [PMID: 26587781]

León-Annicchiarico, C.L.; Ramírez-Peinado, S.; Domínguez-Villanueva, D.; Gonsberg, A.; Lampidis, T.J.; Muñoz-Pinedo, C. ATF 4 mediates necrosis induced by glucose deprivation and apoptosis induced by 2-deoxyglucose in the same cells. FEBS J., 2015, 282(18), 3647-3658.
[http://dx.doi.org/10.1111/febs.13369] [PMID: 26172539]

Chevalier, M.F.; Trabanelli, S.; Racle, J.; Salomé, B.; Cesson, V.; Gharbi, D.; Bohner, P.; Domingos-Pereira, S.; Dartiguenave, F.; Fritschi, A.S.; Speiser, D.E.; Rentsch, C.A.; Gfeller, D.; Jichlinski, P.; Nardelli-Haefliger, D.; Jandus, C.; Derré, L. ILC2-modulated T cell–to-MDSC balance is associated with bladder cancer recurrence. J. Clin. Invest., 2017, 127(8), 2916-2929.
[http://dx.doi.org/10.1172/JCI89717] [PMID: 28650339]

Condamine, T.; Kumar, V.; Ramachandran, I.R.; Youn, J.I.; Celis, E.; Finnberg, N.; El-Deiry, W.S.; Winograd, R.; Vonderheide, R.H.; English, N.R.; Knight, S.C.; Yagita, H.; McCaffrey, J.C.; Antonia, S.; Hockstein, N.; Witt, R.; Masters, G.; Bauer, T.; Gabrilovich, D.I. ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R–mediated apoptosis. J. Clin. Invest., 2014, 124(6), 2626-2639.
[http://dx.doi.org/10.1172/JCI74056] [PMID: 24789911]

Huang, S.; Song, Z.; Zhang, T.; He, X.; Huang, K.; Zhang, Q.; Shen, J.; Pan, J. Identification of immune cell infiltration and immune-related genes in the tumor microenvironment of glioblastomas. Front. Immunol., 2020, 11, 585034.
[http://dx.doi.org/10.3389/fimmu.2020.585034] [PMID: 33193404]

Ledderose, S.; Rodler, S.; Eismann, L.; Ledderose, G.; Ledderose, C. Tumor-infiltrating lymphocytes predict survival in ≥ pT2 urothelial bladder cancer. Pathol. Res. Pract., 2022, 237, 154037.
[http://dx.doi.org/10.1016/j.prp.2022.154037] [PMID: 35908386]

Nie, Z.; Chen, M.; Wen, X.; Gao, Y.; Huang, D.; Cao, H.; Peng, Y.; Guo, N.; Ni, J.; Zhang, S. Endoplasmic reticulum stress and tumor microenvironment in bladder cancer: The missing link. Front. Cell Dev. Biol., 2021, 9, 683940.
[http://dx.doi.org/10.3389/fcell.2021.683940] [PMID: 34136492]

Deng, H.; Zhou, Z.; Yang, W.; Lin, L.; Wang, S.; Niu, G.; Song, J.; Chen, X. Endoplasmic reticulum targeting to amplify immunogenic cell death for cancer immunotherapy. Nano Lett., 2020, 20(3), 1928-1933.
[http://dx.doi.org/10.1021/acs.nanolett.9b05210] [PMID: 32073871]

Jacob, J.S.; Dutra, B.E.; Garcia-Rodriguez, V.; Panneerselvam, K.; Abraham, F.O.; Zou, F.; Ma, W.; Grivas, P.; Thompson, J.A.; Altan, M.; Oliva, I.C.G.; Zhang, H.C.; Thomas, A.S.; Wang, Y. Clinical characteristics and outcomes of oral mucositis associated with immune checkpoint inhibitors in patients with cancer. J. Natl. Compr. Canc. Netw., 2021, 19(12), 1415-1424.
[http://dx.doi.org/10.6004/jnccn.2020.7697] [PMID: 34348238]

Disis, M.L.N.; Guthrie, K.A.; Liu, Y.; Coveler, A.L.; Higgins, D.M.; Childs, J.S.; Dang, Y.; Salazar, L.G. Safety and outcomes of a plasmid DNA vaccine encoding the ERBB2 intracellular domain in patients with advanced-stage ERBB2-positive breast cancer: A phase 1 nonrandomized clinical trial. JAMA Oncol., 2022.
[PMID: 36326756]