Title:A Systematic Review on the Potential Applications of Theranostic
Nanoparticles in Diabetes and its Associated Complication Diabetic
Neuropathy
Volume: 14
Issue: 3
Author(s): Uddhav Patangia, Kalpita Bhatta, Himangi Vig, Sneh Priya, Ankita Wal, Lalit Kumar Tyagi and Pranay Wal*
Affiliation:
- Department of Pharmacy, Panveer Singh Institute of Technology, NH 19 Bhaunti Kanpur Uttar Pradesh, India
Keywords:
Diabetes neuropathy, theranostics, nanotechnology, nanoparticles, inhalable nanoparticles, multiwalled carbon nanotubes.
Abstract:
Background: Diabetes neuropathy is a frequent ailment that has a substantial impact
on patients by increasing the risk of falls and causing discomfort. The lower extremities are where
diabetic neuropathy patients first feel pain. This discomfort could seem like a pinprick, an electric
shock, or something else.
Objective: Here, we give a comprehensive overview of this quickly developing theranostic application
that includes all relevant imaging, diagnostic, therapeutic, and monitoring elements for the
management of diabetes and diabetes neuropathy.
Methods: The data for the current study was gathered by searching PubMed and Google Scholar.
Several research and review publications from various publishers, including Springer Nature,
Bentham Science, PLOS one, MDPI, and ACS Publishing Centre, were evaluated to compile the
data.
Result: Recent developments in theranostics have shown promise as alternate management approaches
for diabetes and ailments linked to diabetes. Numerous nanotechnology-built biosensors,
including multiwalled carbon nanotubes, copper nanowires, zinc oxide tetrapods, and nanoparticle-
embedded contact lenses, offer benefits in monitoring diabetic neuropathy.
Conclusion: The potency, usability, and dependability of insulin substitutes have been demonstrated
by a variety of innovative methods for the management of diabetes, which includes nanotechnology
approaches using Gene-Based Nanoparticles (siRNA), Liposomes, Exosomes/
Extracellular Vesicles, Neuromodulation, and Inhalable Nanoparticles. Over the past few
years, the development of various theranostic nanoparticles for Diabetic neuropathy has experienced
an unprecedented expansion. Even though much work needs to be done to precisely evaluate
the genuine benefits provided by these particles, such as issues with nanotoxicity, theranostic
nanoparticles will have a significant impact on the field of nanomedicine.
