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Review Article

芳香l-氨基酸脱羧酶和神经胶质源性神经营养因子靶向壳核治疗帕金森病的潜在治疗方法

卷 24, 期 4, 2024

发表于: 19 January, 2024

页: [278 - 291] 页: 14

弟呕挨: 10.2174/0115665232283842240102073002

价格: $65

摘要

帕金森病(PD)是一种以多巴胺能神经元特异性丧失为特征的神经退行性疾病，导致运动受损。其流行率是过去25年的两倍，影响到1000多万人。缺乏治疗仍然使用左旋多巴和其他选择作为疾病管理措施。治疗转向基因治疗(GT)，它利用在目标区域直接传递特定基因。因此，使用芳香l-氨基酸脱羧酶(AADC)和胶质源性神经营养因子(GDNF)治疗PD达到了有效的控制。通过减少给药频率，同时使用provasin和AADC作为多巴胺能保护治疗，诊断为PD的患者可能会获得更好的治疗效果。提高纹状体中酪氨酸羟化酶(TH)、糖皮质激素(GCH)和AADC的酶活性可能有助于外源性左旋多巴恢复多巴胺(DA)水平。谷氨酸脱羧酶(GAD)在丘脑底核(STN)中的表达增加也可能对PD有益。将GDNF特异性靶向于壳层区治疗在临床上是合理的，对保护多巴胺能神经元是有益的。此外，临床前和临床研究支持GDNF在神经系统疾病中显示其神经保护作用的作用。另一种Ret受体属于酪氨酸激酶家族，在多巴胺能神经元和声音中表达，在抑制PD的进展中起重要作用。GDNF与这些受体结合，形成受体-配体复合物。另一方面，通过脂质体和包封细胞途径静脉给药重组GDNF，可以安全有效地将神经营养因子分配到壳核和实质。目前的综述强调GT靶向GDNF和AADC治疗的率，以及相应的经验证据。

关键词: 帕金森病，神经胶质源性神经营养因子，芳香l -氨基酸脱羧酶，基因治疗，酪氨酸羟化酶，中性营养因子治疗。

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