摘要
胶质母细胞瘤(GBM)是主要类型的原发性脑肿瘤中最具侵袭性和致命性的。它表现出恶性生长,浸润脑组织,并对治疗表现出耐药性。GBM是一种复杂的疾病,具有高度的异质性。在肿瘤生长过程中,小胶质细胞和星形胶质细胞等细胞浸润肿瘤微环境,广泛参与胶质瘤的形成。肿瘤相关巨噬细胞(tam),无论是来自外周还是代表脑内小胶质细胞,都是GBM肿瘤微环境中数量最多的非肿瘤性群体。局部炎性肿瘤微环境促进了GBM细胞复杂的异质性,主要诱导肿瘤侵袭性和耐药。GBM的免疫抑制肿瘤微环境为肿瘤免疫逃避提供了多种途径,促进了肿瘤的进展。此外,tam和星形胶质细胞可以通过释放细胞因子和激活信号通路促进肿瘤进展。在这篇综述中,我们总结了微环境在GBM进展中的作用,重点是神经炎症。这些微环境研究的最新进展有可能在未来的时间里为GBM的治疗提供一个有希望的方法。
关键词: 胶质母细胞瘤,肿瘤微环境,神经炎症,tam,小胶质细胞,星形胶质细胞。
[http://dx.doi.org/10.1001/jama.2013.280319] [PMID: 24193082]
[http://dx.doi.org/10.1056/NEJM200101113440207] [PMID: 11150363]
[http://dx.doi.org/10.1016/j.neuroscience.2022.03.030] [PMID: 35395355]
[http://dx.doi.org/10.1007/s11060-022-03974-0] [PMID: 35267132]
[http://dx.doi.org/10.1016/j.joim.2023.01.005] [PMID: 36805391]
[http://dx.doi.org/10.1093/neuonc/noy131] [PMID: 30445539]
[http://dx.doi.org/10.1101/gad.1596707] [PMID: 17974913]
[http://dx.doi.org/10.1007/s12094-016-1497-x] [PMID: 26960561]
[http://dx.doi.org/10.3389/fimmu.2020.01402] [PMID: 32765498]
[http://dx.doi.org/10.3390/cells10030607] [PMID: 33803414]
[http://dx.doi.org/10.3389/fphar.2021.680021] [PMID: 34084145]
[http://dx.doi.org/10.3389/fncel.2022.941263] [PMID: 35722623]
[PMID: 19969634]
[http://dx.doi.org/10.1002/glia.21136] [PMID: 21446047]
[http://dx.doi.org/10.1016/j.ccell.2017.02.009] [PMID: 28292436]
[http://dx.doi.org/10.1016/j.stem.2017.10.002] [PMID: 29100012]
[http://dx.doi.org/10.1007/s12035-018-0880-8] [PMID: 29363044]
[http://dx.doi.org/10.3389/fimmu.2018.02924] [PMID: 30619286]
[http://dx.doi.org/10.1016/j.biopha.2020.110086] [PMID: 32172060]
[http://dx.doi.org/10.1080/21645515.2017.1303582] [PMID: 28362548]
[http://dx.doi.org/10.1038/labinvest.2017.19] [PMID: 28287634]
[http://dx.doi.org/10.1186/s12974-022-02630-8] [PMID: 36403059]
[http://dx.doi.org/10.1158/1078-0432.CCR-18-1627] [PMID: 30804019]
[http://dx.doi.org/10.3390/ijms23052509] [PMID: 35269652]
[http://dx.doi.org/10.1038/nn.4185] [PMID: 26713745]
[http://dx.doi.org/10.1038/s41416-018-0258-8] [PMID: 30393372]
[http://dx.doi.org/10.1186/s40035-020-00221-2] [PMID: 33239064]
[http://dx.doi.org/10.3389/fphar.2020.00368] [PMID: 32322199]
[http://dx.doi.org/10.1186/s40478-021-01156-z] [PMID: 33766119]
[http://dx.doi.org/10.1002/path.4133] [PMID: 23096265]
[http://dx.doi.org/10.3390/ijms22073301] [PMID: 33804873]
[http://dx.doi.org/10.3389/fncel.2018.00235] [PMID: 30123112]
[http://dx.doi.org/10.3390/ijms19020436] [PMID: 29389898]
[http://dx.doi.org/10.1093/brain/awac222] [PMID: 35899587]
[http://dx.doi.org/10.1093/neuonc/noq082] [PMID: 20667896]
[http://dx.doi.org/10.1002/glia.22298] [PMID: 22290798]
[http://dx.doi.org/10.1016/j.lungcan.2017.01.003] [PMID: 28285690]
[http://dx.doi.org/10.3390/biom7020034] [PMID: 28346397]
[http://dx.doi.org/10.1007/s13577-021-00619-8] [PMID: 34591282]
[http://dx.doi.org/10.1016/j.jprot.2014.01.024] [PMID: 24503185]
[http://dx.doi.org/10.1111/bph.12008] [PMID: 23062197]
[http://dx.doi.org/10.1016/j.semcdb.2019.05.004] [PMID: 31077796]
[http://dx.doi.org/10.1038/s41416-021-01515-6] [PMID: 34349251]
[http://dx.doi.org/10.1111/j.1600-065X.2008.00607.x] [PMID: 18364000]
[http://dx.doi.org/10.1073/pnas.1007654108] [PMID: 21118979]
[http://dx.doi.org/10.1002/jcp.24260] [PMID: 23065796]
[http://dx.doi.org/10.1155/2017/9634172] [PMID: 28630875]
[http://dx.doi.org/10.1002/glia.23696] [PMID: 31400163]
[http://dx.doi.org/10.1158/2159-8290.CD-20-1808] [PMID: 33811125]
[http://dx.doi.org/10.1016/j.biomaterials.2018.01.053] [PMID: 29421553]
[http://dx.doi.org/10.3389/fimmu.2018.02750] [PMID: 30542347]
[http://dx.doi.org/10.1186/s12974-023-02766-1] [PMID: 36944954]
[http://dx.doi.org/10.20892/j.issn.2095-3941.2019.0353] [PMID: 32296583]
[http://dx.doi.org/10.3390/ijms22115775] [PMID: 34071306]
[http://dx.doi.org/10.1093/carcin/bgr289] [PMID: 22159219]
[http://dx.doi.org/10.1016/j.neuint.2016.12.013] [PMID: 28025034]
[http://dx.doi.org/10.1038/s41467-019-10493-6] [PMID: 31186414]
[http://dx.doi.org/10.3892/or_00000574] [PMID: 19885586]
[http://dx.doi.org/10.1038/onc.2015.210] [PMID: 26165844]
[http://dx.doi.org/10.1158/0008-5472.CAN-12-1600] [PMID: 23090120]
[http://dx.doi.org/10.1523/JNEUROSCI.5048-07.2008] [PMID: 18448647]
[http://dx.doi.org/10.1177/1073858413504466] [PMID: 24106265]
[http://dx.doi.org/10.1093/carcin/bgw068] [PMID: 27287871]
[http://dx.doi.org/10.1002/glia.10147] [PMID: 12379912]
[http://dx.doi.org/10.1038/nature21029] [PMID: 28099414]
[http://dx.doi.org/10.1007/s11481-007-9070-6] [PMID: 18040839]
[http://dx.doi.org/10.3389/fimmu.2019.00865] [PMID: 31130944]
[http://dx.doi.org/10.1098/rstb.2016.0477] [PMID: 29158308]
[http://dx.doi.org/10.1098/rstb.2013.0592] [PMID: 25225086]
[http://dx.doi.org/10.4049/jimmunol.0901352] [PMID: 20622113]
[http://dx.doi.org/10.1007/978-94-007-4719-7_10] [PMID: 22879070]
[http://dx.doi.org/10.1038/nri2506] [PMID: 19197294]
[http://dx.doi.org/10.1158/1535-7163.MCT-09-0734] [PMID: 20053772]
[http://dx.doi.org/10.1007/s11060-014-1382-9] [PMID: 24477623]
[http://dx.doi.org/10.1016/j.canlet.2014.07.034] [PMID: 25079688]
[http://dx.doi.org/10.14336/AD.2018.0720] [PMID: 31165009]
[http://dx.doi.org/10.18632/oncotarget.11515] [PMID: 27613828]
[http://dx.doi.org/10.4161/jkst.22925] [PMID: 24058789]
[http://dx.doi.org/10.1002/ijc.29380] [PMID: 25487790]
[http://dx.doi.org/10.1007/s11060-010-0273-y] [PMID: 20589525]
[http://dx.doi.org/10.1146/annurev-pathol-012513-104720] [PMID: 23937437]
[http://dx.doi.org/10.1084/jem.20100587] [PMID: 20876310]
[PMID: 27774466]
[http://dx.doi.org/10.18632/oncotarget.11825] [PMID: 27602954]
[http://dx.doi.org/10.1038/onc.2017.404] [PMID: 29155422]
[http://dx.doi.org/10.1016/j.clineuro.2013.12.004] [PMID: 24582432]
[http://dx.doi.org/10.4049/jimmunol.166.12.7282] [PMID: 11390478]
[http://dx.doi.org/10.1007/s00262-021-02872-0] [PMID: 33576874]
[http://dx.doi.org/10.3389/fimmu.2019.02453] [PMID: 31681327]
[http://dx.doi.org/10.3390/cells10010056] [PMID: 33401460]
[http://dx.doi.org/10.1074/jbc.M111.292540] [PMID: 21896488]
[http://dx.doi.org/10.1016/j.canlet.2020.09.028] [PMID: 33022290]
[http://dx.doi.org/10.1093/neuonc/now258] [PMID: 28339582]
[http://dx.doi.org/10.1038/s41419-017-0061-0] [PMID: 29371595]
[http://dx.doi.org/10.3389/fimmu.2020.00737] [PMID: 32391020]
[http://dx.doi.org/10.3389/fimmu.2019.00475] [PMID: 30936876]
[http://dx.doi.org/10.1158/0008-5472.CAN-16-0144] [PMID: 27530322]
[http://dx.doi.org/10.1002/stem.2393] [PMID: 27145382]
[http://dx.doi.org/10.3389/fimmu.2022.1050484] [PMID: 36458011]
[http://dx.doi.org/10.2741/2692] [PMID: 17981560]
[http://dx.doi.org/10.1016/bs.ircmb.2016.09.007] [PMID: 28215534]
[http://dx.doi.org/10.1016/j.semcancer.2012.01.011] [PMID: 22313874]
[http://dx.doi.org/10.1515/revneuro-2017-0032] [PMID: 28822229]
[http://dx.doi.org/10.1016/j.humimm.2009.03.011] [PMID: 19332096]
[http://dx.doi.org/10.1002/path.5569] [PMID: 33044746]
[http://dx.doi.org/10.1111/j.1749-6632.2009.05024.x] [PMID: 19845620]
[http://dx.doi.org/10.1007/s00109-010-0683-5] [PMID: 20865400]
[http://dx.doi.org/10.1007/s00109-010-0706-2] [PMID: 21161499]
[http://dx.doi.org/10.1038/cddis.2013.562] [PMID: 24457964]
[PMID: 24966838]
[http://dx.doi.org/10.2174/1871520615666150824153032]
[http://dx.doi.org/10.18632/oncotarget.13295] [PMID: 27863376]
[http://dx.doi.org/10.1227/01.NEU.0000324896.26088.EF] [PMID: 18812968]
[http://dx.doi.org/10.3389/fnins.2017.00590] [PMID: 29123467]
[http://dx.doi.org/10.1016/j.yexcr.2020.111893] [PMID: 32035133]
[http://dx.doi.org/10.1002/path.2908] [PMID: 21618540]
[http://dx.doi.org/10.1038/nature05236] [PMID: 17051156]
[http://dx.doi.org/10.4049/jimmunol.1103248] [PMID: 22664874]
[http://dx.doi.org/10.1038/ncb3090] [PMID: 25580734]
[http://dx.doi.org/10.7150/thno.41692] [PMID: 33391498]
[http://dx.doi.org/10.1007/s11010-007-9517-3] [PMID: 17551671]
[http://dx.doi.org/10.1074/jbc.M115.664037] [PMID: 26245897]
[http://dx.doi.org/10.1002/cjp2.7] [PMID: 27499894]
[http://dx.doi.org/10.1007/s13311-017-0524-0] [PMID: 28374184]
[http://dx.doi.org/10.1016/j.jocn.2009.05.006] [PMID: 19926287]
[http://dx.doi.org/10.1016/j.stem.2022.09.009] [PMID: 36265493]
[http://dx.doi.org/10.3390/ijms23052646] [PMID: 35269788]
[http://dx.doi.org/10.3390/ijms21061932] [PMID: 32178267]
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