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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

胶质母细胞瘤中的神经炎症:微环境在肿瘤进展中的作用

卷 24, 期 6, 2024

发表于: 17 January, 2024

页: [579 - 594] 页: 16

弟呕挨: 10.2174/0115680096265849231031101449

价格: $65

摘要

胶质母细胞瘤(GBM)是主要类型的原发性脑肿瘤中最具侵袭性和致命性的。它表现出恶性生长，浸润脑组织，并对治疗表现出耐药性。GBM是一种复杂的疾病，具有高度的异质性。在肿瘤生长过程中，小胶质细胞和星形胶质细胞等细胞浸润肿瘤微环境，广泛参与胶质瘤的形成。肿瘤相关巨噬细胞(tam)，无论是来自外周还是代表脑内小胶质细胞，都是GBM肿瘤微环境中数量最多的非肿瘤性群体。局部炎性肿瘤微环境促进了GBM细胞复杂的异质性，主要诱导肿瘤侵袭性和耐药。GBM的免疫抑制肿瘤微环境为肿瘤免疫逃避提供了多种途径，促进了肿瘤的进展。此外，tam和星形胶质细胞可以通过释放细胞因子和激活信号通路促进肿瘤进展。在这篇综述中，我们总结了微环境在GBM进展中的作用，重点是神经炎症。这些微环境研究的最新进展有可能在未来的时间里为GBM的治疗提供一个有希望的方法。

关键词: 胶质母细胞瘤，肿瘤微环境，神经炎症，tam，小胶质细胞，星形胶质细胞。

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图形摘要

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