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Central Nervous System Agents in Medicinal Chemistry

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ISSN (Print): 1871-5249
ISSN (Online): 1875-6166

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Review Article

Effect of Flavonoids against Parkinson’s Disease

Author(s): Himanshi Varshney and Yasir Hasan Siddique*

Volume 24, Issue 2, 2024

Published on: 16 January, 2024

Page: [145 - 165] Pages: 21

DOI: 10.2174/0118715249264078231214074107

Price: $65

Abstract

Parkinson's disease (PD) is the second most common neurodegenerative disorder. It is characterized by the depletion of striatal dopamine content and aggregation of alphasynuclein in the substantia nigra (SN). It is possible to treat the symptoms of PD with a variety of medications, but they often result in complications and are not able to cure or stop the progression of the disease. Flavonoids (the phytocomponents present in almost all fruits and vegetables) are the class of secondary metabolites that have generated a peak of interest because of their medicinal properties, including a reduction in the risk of PD. Several flavonoids such as quercetin, kaempferol, hesperitin, anthocyanin and many more have been reported for their anti- Parkinson’s effect. This review deals with the neuroprotective benefits of different classes of flavonoids against PD.

Keywords: Parkinson's disease, flavonoids, oxidative stress, neurodegenerative disorders, synuclein, dopamine.

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