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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

肠道菌群相关代谢物在胃肠道癌症中的影响研究

卷 24, 期 6, 2024

发表于: 11 January, 2024

页: [612 - 628] 页: 17

弟呕挨: 10.2174/0115680096274860231111210214

价格: $65

摘要

胃肠道(GI)癌症由于其患病率、对福祉的影响、高死亡率、经济负担以及预防和早期发现的潜力而成为一个主要的健康问题。胃肠道癌症研究在了解生物学、风险因素和治疗选择方面取得了显著进展。一个新兴的研究领域是肠道微生物组在胃肠道癌症发展和治疗反应中的作用。肠道微生物群对消化、代谢和免疫功能至关重要，与胃肠道癌症的关系越来越密切。生态失调和肠道微生物组成的改变可能导致癌症的发展。科学家研究特定细菌或微生物代谢物如何影响癌症进展和治疗反应。调节肠道微生物群在提高治疗效果和预防胃肠道癌症方面显示出希望。肠道菌群失调可通过炎症、代谢物产生、遗传毒性和免疫调节影响胃肠道癌症。微生物产生代谢物，如短链脂肪酸、胆汁酸和次级代谢物。它们影响宿主细胞，影响细胞增殖、细胞凋亡、DNA损伤和免疫调节等过程，这些过程都与癌症的发展有关。本文综述了胃肠道肿瘤中肠道微生物代谢产物及其分子机制的最新研究进展。希望这一尝试将有助于开展其他相关研究，以揭示所涉及的确切机制，识别与胃肠道癌症相关的微生物特征，并开发靶点。

关键词: 微生物衍生代谢物，胃肠道癌症，双重作用，肠道微生物群，肠道微生物群失调，代谢物产生。

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