Generic placeholder image

Current Drug Safety

Editor-in-Chief

ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

Case Report

Treatment Modalities for Trigeminal Neuralgia and the Need for Vigilance in Monitoring Adverse Drug Events: A Case Report

Author(s): Raja Narendra Divakar Addanki, Anjali Srikanth Mannava, Hemasri Velmurugan and Pugazhenthan Thangaraju*

Volume 19, Issue 4, 2024

Published on: 09 January, 2024

Page: [482 - 488] Pages: 7

DOI: 10.2174/0115748863215954231214073053

Price: $65

Abstract

Introduction: Trigeminal neuralgia is a rare condition characterised by paroxysms of intense pain in the distribution of the trigeminal nerve. This condition significantly diminishes the patient's quality of life, and the side effects from chronic use of medications for symptomatic relief further exacerbate their distress.

Case Description: The case report discusses a patient diagnosed with Trigeminal Neuralgia who commenced carbamazepine treatment. The report tracks the disease's progression, medication adjustments, and the eventual emergence of vertigo due to long-term carbamazepine use.

Conclusion: The article covers fundamental information about trigeminal neuralgia and its management and also offers a comprehensive review of the basics of vertigo. It delves into carbamazepine's mechanism of action and its associated side effects. The paper also looks at prospective therapy changes that could improve patients' quality of life.

Keywords: trigeminal neuralgia, vertigo, diagnosis, patient care management, carbamazepine, pregabalin.

Graphical Abstract
[1]
Cole CD, Liu JK, Apfelbaum RI. Historical perspectives on the diagnosis and treatment of trigeminal neuralgia. Neurosurg Focus 2005; 18(5): 1-10.
[http://dx.doi.org/10.3171/foc.2005.18.5.5] [PMID: 15913280]
[2]
Khawaja SN, Scrivani SJ. Trigeminal neuralgia. Dent Clin North Am 2023; 67(1): 99-115.
[http://dx.doi.org/10.1016/j.cden.2022.07.008] [PMID: 36404084]
[3]
Love S, Coakham HB. Trigeminal neuralgia: Pathology and pathogenesis. Brain 2001; 124(12, December): 2347-60.
[http://dx.doi.org/10.1093/brain/124.12.2347]
[4]
Rasmussen P. Facial pain. Acta Neurochir 1991; 108(3-4): 100-9.
[http://dx.doi.org/10.1007/BF01418516] [PMID: 2031469]
[5]
Luo Y, He M, Li C, Yang H. A research on quality of life score (QOLS) of patients with trigeminal neuralgia (TN). J Infect Public Health 2019; 12(5): 690-4.
[http://dx.doi.org/10.1016/j.jiph.2019.03.011] [PMID: 31101490]
[6]
Chimirri S, Aiello R, Mazzitello C, et al. Vertigo/dizziness as a Drugs’ adverse reaction. J Pharmacol Pharmacother 2013; 4(1_suppl): S104-9.
[http://dx.doi.org/10.4103/0976-500X.120969] [PMID: 24347974]
[7]
Misra S, Shukla AK, Jhaj R, Ahmed S, Nanda M, Chaudhary D. Agreement between WHO-UMC causality scale and the Naranjo algorithm for causality assessment of adverse drug reactions. J Family Med Prim Care 2021; 10(9): 3303-8.
[http://dx.doi.org/10.4103/jfmpc.jfmpc_831_21] [PMID: 34760748]
[8]
Eller JL, Raslan AM, Burchiel KJ. Trigeminal neuralgia: Definition and classification. Neurosurg Focus 2005; 18(5): 1-3.
[http://dx.doi.org/10.3171/foc.2005.18.5.4] [PMID: 15913279]
[9]
Cruccu G, Finnerup NB, Jensen TS, et al. Trigeminal neuralgia. Neurology 2016; 87(2): 220-8.
[http://dx.doi.org/10.1212/WNL.0000000000002840] [PMID: 27306631]
[10]
Maarbjerg S, Gozalov A, Olesen J, Bendtsen L. Trigeminal neuralgia-a prospective systematic study of clinical characteristics in 158 patients. Headache 2014; 54(10): 1574-82.
[http://dx.doi.org/10.1111/head.12441] [PMID: 25231219]
[11]
Maarbjerg S, Di Stefano G, Bendtsen L, Cruccu G. Trigeminal neuralgia-diagnosis and treatment. Cephalalgia 2017; 37(7): 648-57.
[http://dx.doi.org/10.1177/0333102416687280] [PMID: 28076964]
[12]
May A, Goadsby PJ. The trigeminovascular system in humans: pathophysiologic implications for primary headache syndromes of the neural influences on the cerebral circulation. J Cereb Blood Flow Metab 1999; 19(2): 115-27.
[http://dx.doi.org/10.1097/00004647-199902000-00001] [PMID: 10027765]
[13]
Simms HN, Honey CR. The importance of autonomic symptoms in trigeminal neuralgia. J Neurosurg 2011; 115(2): 210-6.
[http://dx.doi.org/10.3171/2011.4.JNS101843] [PMID: 21568653]
[14]
Karatas M. Central vertigo and dizziness: Epidemiology, differential diagnosis, and common causes. Neurologist 2008; 14(6): 355-64.
[http://dx.doi.org/10.1097/NRL.0b013e31817533a3] [PMID: 19008741]
[15]
Saccomano SJ. Dizziness, vertigo, and presyncope. Nurse Pract 2012; 37(12): 46-52.
[http://dx.doi.org/10.1097/01.NPR.0000422206.92550.5b] [PMID: 23165136]
[16]
Sura D, Newell S. Vertigo-diagnosis and management in the primary care. BMJ 2010; 3(4): a351.
[17]
Thompson TL, Amedee R. Vertigo: A review of common peripheral and central vestibular disorders. Ochsner J 2009; 9(1): 20-6.
[PMID: 21603405]
[18]
Rogers TS, Noel MA, Garcia B. Dizziness: Evaluation and management. Am Fam Physician 2023; 107(5): 514-23.
[PMID: 37192077]
[19]
Boniver R. Dizziness symptomatology: A functional disorder? Rev Med Liege 2023; 78(5-6): 281-4.
[PMID: 37350202]
[20]
Cianfrone G, Pentangelo D, Cianfrone F, et al. Pharmacological drugs inducing ototoxicity, vestibular symptoms and tinnitus: A reasoned and updated guide. Eur Rev Med Pharmacol Sci 2011; 15(6): 601-36.
[PMID: 21796866]
[21]
Muncie HL, Sirmans SM, James E. Dizziness: Approach to evaluation and management. Am Fam Physician 2017; 95(3): 154-62.
[PMID: 28145669]
[22]
Brandt T, Dieterich M. Vestibular paroxysmia: Vascular compression of the eighth nerve? Lancet 1994; 343(8900): 798-9.
[http://dx.doi.org/10.1016/S0140-6736(94)91879-1] [PMID: 7907760]
[23]
Al-Quliti KW. Update on neuropathic pain treatment for trigeminal neuralgia. Neurosciences 2015; 20(2): 107-14.
[http://dx.doi.org/10.17712/nsj.2015.2.20140501] [PMID: 25864062]
[24]
Cruccu G, Gronseth G, Alksne J, et al. AAN‐EFNS guidelines on trigeminal neuralgia management. Eur J Neurol 2008; 15(10): 1013-28.
[http://dx.doi.org/10.1111/j.1468-1331.2008.02185.x] [PMID: 18721143]
[25]
Zakrzewska JM, Patsalos PN. Long-term cohort study comparing medical (oxcarbazepine) and surgical management of intractable trigeminal neuralgia. Pain 2002; 95(3): 259-66.
[http://dx.doi.org/10.1016/S0304-3959(01)00406-7] [PMID: 11839425]
[26]
Barker FG II, Jannetta PJ, Bissonette DJ, Larkins MV, Jho HD. The long-term outcome of microvascular decompression for trigeminal neuralgia. N Engl J Med 1996; 334(17): 1077-84.
[http://dx.doi.org/10.1056/NEJM199604253341701] [PMID: 8598865]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy