Abstract
The cinnoline nucleus is a bicyclic ring and is an isosteric precursor to quinolone or isoquinoline. Cinnoline analogs are aromatic heterocyclic compounds having diverse therapeutic activities, such as antimicrobial, analgesic, anti-inflammatory, anti-tuberculosis, antimalarial, anticonvulsant, antioxidant, anticancer, antihypertensive, anti-anxiety, and other activities. This heterocyclic nucleus is attracting a lot of attention in medicinal chemistry and is used as a structural subunit in various compounds with attractive medicinal and chemical properties. In this review, we focus on the biological activities of cinnoline analogs with various substitutions.
Keywords: Cinnoline, heterocyclic compounds, cyclization, biological activities.
Mini-Reviews in Organic Chemistry
Title:An Overview of Diverse Biological Activities of Cinnoline Scaffold
Volume: 21
Author(s): Mohammad Asif*, Mamdouh Allahyani, Abdulelah Aljuaid, Mazen M. Almehmadi, Ahad Alsaiari and Abdulaziz Alsharif
Affiliation:
- Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
Keywords: Cinnoline, heterocyclic compounds, cyclization, biological activities.
Abstract: The cinnoline nucleus is a bicyclic ring and is an isosteric precursor to quinolone or isoquinoline. Cinnoline analogs are aromatic heterocyclic compounds having diverse therapeutic activities, such as antimicrobial, analgesic, anti-inflammatory, anti-tuberculosis, antimalarial, anticonvulsant, antioxidant, anticancer, antihypertensive, anti-anxiety, and other activities. This heterocyclic nucleus is attracting a lot of attention in medicinal chemistry and is used as a structural subunit in various compounds with attractive medicinal and chemical properties. In this review, we focus on the biological activities of cinnoline analogs with various substitutions.
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Cite this article as:
Asif Mohammad*, Allahyani Mamdouh, Aljuaid Abdulelah, M. Almehmadi Mazen, Alsaiari Ahad and Alsharif Abdulaziz, An Overview of Diverse Biological Activities of Cinnoline Scaffold, Mini-Reviews in Organic Chemistry 2024; 21 () . https://dx.doi.org/10.2174/0118756298265037231119063008
DOI https://dx.doi.org/10.2174/0118756298265037231119063008 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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