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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Mini-Review Article

Soluble Factors Associated with Denervation-induced Skeletal Muscle Atrophy

Author(s): Marianny Portal Rodríguez and Claudio Cabello-Verrugio*

Volume 25, Issue 3, 2024

Published on: 24 November, 2023

Page: [189 - 199] Pages: 11

DOI: 10.2174/0113892037189827231018092036

Price: $65

Abstract

Skeletal muscle tissue has the critical function of mechanical support protecting the body. In addition, its functions are strongly influenced by the balanced synthesis and degradation processes of structural and regulatory proteins. The inhibition of protein synthesis and/or the activation of catabolism generally determines a pathological state or condition called muscle atrophy, a reduction in muscle mass that results in partial or total loss of function. It has been established that many pathophysiological conditions can cause a decrease in muscle mass. Skeletal muscle innervation involves stable and functional neural interactions with muscles via neuromuscular junctions and is essential for maintaining normal muscle structure and function. Loss of motor innervation induces rapid skeletal muscle fiber degeneration with activation of atrophy-related signaling and subsequent disassembly of sarcomeres, altering normal muscle function. After denervation, an inflammation stage is characterized by the increased expression of pro-inflammatory cytokines that determine muscle atrophy. In this review, we highlighted the impact of some soluble factors on the development of muscle atrophy by denervation.

Keywords: Muscular atrophy, denervation, soluble factors, cytokines, protein synthesis, muscle fiber degeneration, pro-inflammatory cytokines.

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Graphical Abstract

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