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Review Article

The Anti-hypoxia Potentials of Trans-sodium Crocetinate in Hypoxiarelated Diseases: A Review

Author(s): Natalia S. Klunko, Harun Achmad, Tamara Muayad Abdullah, Sami Mohammed, Indranil Saha, Khulood Saadoon Salim, Rasha Fadhel Obaid, Rosario Mireya Romero-Parra, Shaker Shanawa Al-Hasnawi, Wissam Hamid Al-Janabi and Bagher Farhood*

Volume 17, Issue 1, 2024

Published on: 24 October, 2023

Page: [30 - 37] Pages: 8

DOI: 10.2174/0118744710268127231020083505

Price: $65

Abstract

Crocetin is a kind of apocarotenoid carboxylic acid extracted from saffron (Crocus sativus L.), which is effective in upregulating tissue oxygenation. However, crocetin is difficult to solubilize. It was shown that the trans isomer of crocetin is effective in improving oxygen diffusivity, while its cis isomer appears not to be. Hence, the isolated trans isomer of crocetin or trans-sodium crocetinate (TSC) can be used instead of crocetin. It is shown that TSC can upregulate hypoxic tissue oxygenation and be effective in treating some hypoxia-related diseases. Moreover, experimental and clinical studies have reported no adverse effects following TSC treatment, even at high doses. The current study will discuss the potential role of TSC in hemorrhagic shock, ischemia, brain tumor radiotherapy, and others.

Keywords: Trans sodium crocetinate, oxygenation, radiotherapy, brain tumor, ischemia, hemorrhagic shock.

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Graphical Abstract

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