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Review Article

人类猴痘病毒感染的预防和管理研究进展

卷 24, 期 13, 2023

发表于: 12 October, 2023

页: [1032 - 1045] 页: 14

弟呕挨: 10.2174/0113894501258154231008194028

价格: $65

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摘要

背景：在过去几十年中，有几种被忽视的传染性病原体再次出现，包括猴痘病毒，这是一种来自正痘病毒属的病毒，可导致猴痘，并在动物和人类之间传播。人类猴痘疫情已经蔓延到几个不同的国家。由于此次疫情的病例数异常高，而且与流行国家缺乏联系，人们担心猴痘的传播模式可能已经改变。 目的：本研究旨在提供人类猴痘病毒预防和管理的最新进展。 方法：我们在这项工作中强调了在预防和管理人类猴痘病毒方面的最新进展。 结果：为了治疗和预防猴痘，正在使用新的药物和疫苗，需要进行更多的研究来了解猴痘流行地区的流行病学、生物学和生态学，并阻止未来的全球疫情。市场上可用于治疗病毒的疫苗有JYNEOS和ACAM2000。一些抗病毒药物，如替卡韦、布林西多福韦、西多福韦、三氟吡啶和牛痘免疫球蛋白，用于治疗猴痘病毒。一些疫苗，如NIOCH-14、西多福韦、CMX-001和ST-246，目前正在进行临床试验。 结论：本文涵盖了猴痘病毒生物学的特征，这些特征对风险评估和猴痘病毒爆发的准备工作很重要，重点介绍了病毒宿主范围、进化潜力和潜在中和靶点的最新进展。

关键词: 猴痘病毒，病理生理学，预防，治疗，临床试验化合物，感染。

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