Abstract
Cancer stem cells (CSCs) play an essential role in tumour progression and metastasis. Stem cell ability of self-renewal enables it to persist over time, thereby contributing to cancer relapse or recurrence and also resistance to current therapies. Therefore, targeting CSCs emerged as a promising strategy of cancer treatment. CSCs exhibit differentiation, self-renewal, and plasticity, they contribute to formation of malignant tumours, also favors, metastasis, heterogeneity, multidrug resistance, and radiation resistance. Coventional cancer treatments predominantly target cancer cells that are not CSCs, CSCs frequently survive, eventually leading to relapse. This article focuses on the development of novel therapeutic strategies that combine conventional treatments and CSC inhibitors to eradicate cancer cells and CSCs, for the better and permanent treatment. However, the diversity of CSCs is a significant obstacle in the development of CSC-targeted therapies, necessitating extensive research for a better understanding and exploration of therapeutic approaches. Future development of CSC-targeted therapies will rely heavily on overcoming this obstacle.
Keywords: Cancer stem cells, cancer treatment, cancer remission, conventional treatments, tumour recurrence, therapy resistance .
Current Stem Cell Research & Therapy
Title:Cancer Stem Cells and Treatment of Cancer: An Update and Future Perspectives
Volume: 19 Issue: 10
Author(s): Mudassir Khan, Mashal Naeem, Sana Aftab Chaudary, Affan Ahmed and Aftab Ahmed*
Affiliation:
- School of Biological Sciences, Punjab University, Lahore, Pakistan
Keywords: Cancer stem cells, cancer treatment, cancer remission, conventional treatments, tumour recurrence, therapy resistance .
Abstract: Cancer stem cells (CSCs) play an essential role in tumour progression and metastasis. Stem cell ability of self-renewal enables it to persist over time, thereby contributing to cancer relapse or recurrence and also resistance to current therapies. Therefore, targeting CSCs emerged as a promising strategy of cancer treatment. CSCs exhibit differentiation, self-renewal, and plasticity, they contribute to formation of malignant tumours, also favors, metastasis, heterogeneity, multidrug resistance, and radiation resistance. Coventional cancer treatments predominantly target cancer cells that are not CSCs, CSCs frequently survive, eventually leading to relapse. This article focuses on the development of novel therapeutic strategies that combine conventional treatments and CSC inhibitors to eradicate cancer cells and CSCs, for the better and permanent treatment. However, the diversity of CSCs is a significant obstacle in the development of CSC-targeted therapies, necessitating extensive research for a better understanding and exploration of therapeutic approaches. Future development of CSC-targeted therapies will rely heavily on overcoming this obstacle.
Export Options
About this article
Cite this article as:
Khan Mudassir, Naeem Mashal, Chaudary Aftab Sana, Ahmed Affan and Ahmed Aftab*, Cancer Stem Cells and Treatment of Cancer: An Update and Future Perspectives, Current Stem Cell Research & Therapy 2024; 19 (10) . https://dx.doi.org/10.2174/011574888X247548230921063514
DOI https://dx.doi.org/10.2174/011574888X247548230921063514 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Meet Our Editorial Board Member
Recent Patents on Inflammation & Allergy Drug Discovery Biomedical Applications of Protein Microarrays
Current Medicinal Chemistry Evolutionary Computation and QSAR Research
Current Computer-Aided Drug Design Levosimendan: A Novel Agent in Heart Failure
Recent Patents on Cardiovascular Drug Discovery PEGylation of Proteins and Liposomes: a Powerful and Flexible Strategy to Improve the Drug Delivery
Current Drug Metabolism Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs
Recent Patents on Cardiovascular Drug Discovery Future Therapeutic Strategies in Inflammatory Cardiomyopathy: Insights from the Experimental Autoimmune Myocarditis Model
Cardiovascular & Hematological Disorders-Drug Targets Efficacy and Toxicological Studies of Cremophor EL Free Alternative Paclitaxel Formulation
Current Drug Safety SARS-CoV-2 Infection and C1-Esterase Inhibitor: Camouflage Pattern and New Perspective
Current Protein & Peptide Science Present and Future Prospects of the Anti-cancer Activities of Saikosaponins
Current Cancer Drug Targets An Outlook on Pathological Pathways of Diabetes and Molecular Mechanisms of Anti-diabetic Phytobioactives
Letters in Functional Foods The Accomplices of NF-κB Lead to Radioresistance
Current Protein & Peptide Science A Review of Inadequate and Excessive Weight Gain in Pregnancy
Current Women`s Health Reviews Agonists of the Tissue-Protective Erythropoietin Receptor in the Treatment of Parkinson’s Disease
Current Topics in Medicinal Chemistry CCR2 Antagonists
Current Topics in Medicinal Chemistry Therapeutic Drug Monitoring in Pediatric IBD: Current Application and Future Perspectives
Current Medicinal Chemistry Role of Probiotics and Functional Foods in Health: Gut Immune Stimulation by Two Probiotic Strains and a Potential Probiotic Yoghurt
Endocrine, Metabolic & Immune Disorders - Drug Targets A Critical Review of Bioactive Food Components, and of their Functional Mechanisms, Biological Effects and Health Outcomes
Current Pharmaceutical Design Melatonin Decreases Levels of S100β and NFκB, Increases Levels of Synaptophysinina Rat Model of Alzheimer's Disease
Current Aging Science Non-Alcoholic Steatohepatitis: New Insights from OMICS Studies
Current Pharmaceutical Biotechnology