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Current Stem Cell Research & Therapy

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ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

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Review Article

Clinical Trials of Mesenchymal Stem Cells for the Treatment of COVID 19

Author(s): Elham Zendedel, Lobat Tayebi, Mohammad Nikbakht, Elham Hasanzadeh* and Shiva Asadpour*

Volume 19, Issue 8, 2024

Published on: 05 October, 2023

Page: [1055 - 1071] Pages: 17

DOI: 10.2174/011574888X260032230925052240

Price: $65

Abstract

Mesenchymal Stem Cells (MSCs) are being investigated as a treatment for a novel viral disease owing to their immunomodulatory, anti-inflammatory, tissue repair and regeneration characteristics, however, the exact processes are unknown. MSC therapy was found to be effective in lowering immune system overactivation and increasing endogenous healing after SARS-CoV-2 infection by improving the pulmonary microenvironment. Many studies on mesenchymal stem cells have been undertaken concurrently, and we may help speed up the effectiveness of these studies by collecting and statistically analyzing data from them. Based on clinical trial information found on clinicaltrials. gov and on 16 November 2020, which includes 63 clinical trials in the field of patient treatment with COVID-19 using MSCs, according to the trend of increasing studies in this field, and with the help of meta-analysis studies, it is possible to hope that the promise of MSCs will one day be realized. The potential therapeutic applications of MSCs for COVID-19 are investigated in this study.

Keywords: Covid-19, mesenchymal stem cell (MSCs), clinical trials, cell therapy, regenerative medicine, SARS-CoV-2.

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