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Pharmaceutical Nanotechnology

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ISSN (Print): 2211-7385
ISSN (Online): 2211-7393

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Review Article

Pharmaceutical/Biomedical Applications of Electrospun Nanofibers - Comprehensive Review, Attentive to Process Parameters and Patent Landscape

Author(s): Varshini Hemmanahalli Ramesh, Prakash Goudanavar, Bevenahalli Ramesh, Nimbagal Raghavendra Naveen* and Buduru Gowthami

Volume 12, Issue 5, 2024

Published on: 06 October, 2023

Page: [412 - 427] Pages: 16

DOI: 10.2174/2211738511666230911163249

Price: $65

Abstract

Nanotechnology is a new science and business endeavour with worldwide economic benefits. Growing knowledge of nanomaterial fabrication techniques has increased the focus on nanomaterial preparation for various purposes. Nanofibers are one-dimensional nanomaterials having distinct physicochemical properties and characteristics. Nanofibers are nanomaterial types with a cross-sectional dimension of tens to hundreds of nanometres. They may create high porosity mesh networks with significant interconnections among pores, making them suitable for advanced applications. Electrospinning stands out for its ease of use, flexibility, low cost, and variety among the approaches described in the literature. The most common method for making nanofibers is electrospinning. This article extensively describes and summarizes the impact of various process variables on the fabrication of nanofibers. Special attention has been given to scientific and patent prospection to confirm the research interests in nanofibers.

Keywords: Nanofibers, electrospinning, patent prospection, nanotechnology, biomedical applications, one-dimensional.

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Hardwicke J.T.; Hart J.; Bell A.; Duncan R.; Thomas D.W.; Moseley R.; The effect of dextrin–rhEGF on the healing of full-thickness, excisional wounds in the (db/db) diabetic mouse. J Control Release 2011,152(3),411-417 10.1016/j.jconrel.2011.03.016 21435363 Kaufman M.W.; Wigley D.; Recurring wounds in a diabetic with multiple medical problems: Lower extremity wound care. Int J Low Extrem Wounds 2004,3(1),43-46 10.1177/1534734604263477 15866787 Ganie F.A.; The increasing rate of secondary amputation in popliteal arterial injury associated with multi-organ injuries and hypotension. Int Cardiovasc Res J 2012,6(4),124-127 Winkler M.A.; Dib C.; Ljubimov A.V.; Saghizadeh M.; Targeting miR-146a to treat delayed wound healing in human diabetic organ-cultured corneas. PLoS One 2014,9(12),e114692 10.1371/journal.pone.0114692 25490205 Leung V.; Hartwell R.; Elizei S.S.; Yang H.; Ghahary A.; Ko F.; Postelectrospinning modifications for alginate nanofiber-based wound dressings. J Biomed Mater Res B Appl Biomater 2014,102(3),508-515 10.1002/jbm.b.33028 24155096 Ahire J.J.; Dicks L.M.T.; 2,3-dihydroxybenzoic acid-containing nanofiber wound dressings inhibit biofilm formation by Pseudomonas aeruginosa. Antimicrob Agents Chemother 2014,58(4),2098-2104 10.1128/AAC.02397-13 24449781 Ketabchi N.; Naghibzadeh M.; Adabi M.; Esnaashari S.S.; Faridi-Majidi R.; Preparation and optimization of chitosan/polyethylene oxide nanofiber diameter using artificial neural networks. Neural Comput Appl 2017,28(11),3131-3143 10.1007/s00521-016-2212-0 Çalamak S.; Erdoğdu C, Özalp M, Ulubayram K. Silk fibroin based antibacterial bionanotextiles as wound dressing materials. Mater Sci Eng C 2014,43,11-20 10.1016/j.msec.2014.07.001 25175182 Huang Z.M.; Zhang Y.Z.; Kotaki M.; Ramakrishna S.; A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Compos Sci Technol 2003,63(15),2223-2253 10.1016/S0266-3538(03)00178-7 Wang X.; Sng M.K.; Foo S.; Early controlled release of peroxisome proliferator-activated receptor β/δ agonist GW501516 improves diabetic wound healing through redox modulation of wound microenvironment. J Control Release 2015,197,138-147 10.1016/j.jconrel.2014.11.001 25449811 Gilchrist S.E.; Lange D.; Letchford K.; Bach H.; Fazli L.; Burt H.M.; Fusidic acid and rifampicin co-loaded PLGA nanofibers for the prevention of orthopedic implant associated infections. J Control Release 2013,170(1),64-73 10.1016/j.jconrel.2013.04.012 23639451 Cash K.J.; Clark H.A.; Nanosensors and nanomaterials for monitoring glucose in diabetes. Trends Mol Med 2010,16(12),584-593 10.1016/j.molmed.2010.08.002 20869318 Manesh K.M.; Santhosh P.; Gopalan A.; Lee K.P.; Electrospun poly(vinylidene fluoride)/poly(aminophenylboronic acid) composite nanofibrous membrane as a novel glucose sensor. Anal Biochem 2007,360(2),189-195 10.1016/j.ab.2006.09.021 17123457 Sill T.J.; von Recum H.A.; Electrospinning: Applications in drug delivery and tissue engineering. Biomaterials 2008,29(13),1989-2006 10.1016/j.biomaterials.2008.01.011 18281090 Hu X.; Liu S.; Zhou G.; Huang Y.; Xie Z.; Jing X.; Electrospinning of polymeric nanofibers for drug delivery applications. J Control Release 2014,185,12-21 10.1016/j.jconrel.2014.04.018 24768792 Pilehvar-Soltanahmadi Y.; Dadashpour M.; Mohajeri A.; Fattahi A.; Sheervalilou R.; Zarghami N.; An overview on application of natural substances incorporated with electrospun nanofibrous scaffolds to development of innovative wound dressings. Mini Rev Med Chem 2018,18(5),414-427 10.2174/1389557517666170308112147 28271816 Mele E.; Electrospinning of natural polymers for advanced wound care: Towards responsive and adaptive dressings. J Mater Chem B Mater Biol Med 2016,4(28),4801-4812 10.1039/C6TB00804F 32263137 Zahedi P.; Rezaeian I.; Ranaei-Siadat S.O.; Jafari S.H.; Supaphol P.; A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polym Adv Technol 2010,21(2),77-95 10.1002/pat.1625 Gunn J.; Zhang M.; Polyblend nanofibers for biomedical applications: Perspectives and challenges. Trends Biotechnol 2010,28(4),189-197 10.1016/j.tibtech.2009.12.006 20116113 Abrigo M.; McArthur S.L.; Kingshott P.; Electrospun nanofibers as dressings for chronic wound care: Advances, challenges, and future prospects. Macromol Biosci 2014,14(6),772-792 10.1002/mabi.201300561 24678050 Rieger K.A.; Birch N.P.; Schiffman J.D.; Designing electrospun nanofiber mats to promote wound healing – a review. J Mater Chem B Mater Biol Med 2013,1(36),4531-4541 10.1039/c3tb20795a 32261196 Xia Y.; Yang P.; Sun Y.; One-Dimensional Nanostructures: Synthesis, Characterization, and Applications. Adv Mater 2003,15 Li D.; Xia Y.; Electrospinning of nanofibers: Reinventing the wheel? Adv Mater 2004,16(14),1151-1170 Ramakrishna S.; Fujihara K.; Teo W.E.; Lim T.C.; Ma Z.; An Introduction to Electrospinning and Nanofibers 2005 10.1142/5894 Sahoo S.; Ouyang H.W.; Goh J.C-H.; Tay T-E.; Toh S.L.; Towards an ideal polymer scaffold for tendon/ligament tissue engineering. Third International Conference on Experimental Mechanics and Third Conference of the Asian Committee on Experimental Mechanics 2005 Li W.J.; Laurencin C.T.; Caterson E.J.; Tuan R.S.; Ko F.K.; Electrospun nanofibrous structure: A novel scaffold for tissue engineering. J Biomed Mater Res 2002,60(4),613-621 10.1002/jbm.10167 11948520 Barhate R.S.; Loong C.K.; Ramakrishna S.; Preparation and characterization of nanofibrous filtering media. J Membr Sci 2006,283(1-2),209-218 10.1016/j.memsci.2006.06.030 Bergshoef M.M.; Vancso G.J.; Transparent nanocomposites with ultrathin, electrospun Nylon-4,6 fiber reinforcement. Adv Mater 1999,11(16),1362-1365 10.1002/(SICI)1521-4095(199911)11:16<1362:AID-ADMA1362>3.0.CO;2-X Schultz G.S.; Sibbald R.G.; Falanga V.; Wound bed preparation: A systematic approach to wound management. Wound Repair Regen 2003,11(S1),S1-S28 10.1046/j.1524-475X.11.s2.1.x 12654015 Long Y.Z.; Li M.M.; Gu C.; Recent Advances in Synthesis, Physical Properties and Applications of Conducting Polymer Nanotubes and Nanofibers 2011,36 Abe K.; Iwamoto S.; Yano H.; Obtaining cellulose nanofibers with a uniform width of 15 nm from wood. Biomacromolecules 2007,8(10),3276-3278 10.1021/bm700624p 17784769 Prabu G.T.V.; Dhurai B.; A novel profiled multi-pin electrospinning system for nanofiber production and encapsulation of nanoparticles into nanofibers. Sci Rep 2020,10(1),4302 10.1038/s41598-020-60752-6 32152364 Luo C.J.; Stoyanov S.D.; Stride E.; Pelan E.; Edirisinghe M.; Electrospinning versus fibre production methods: From specifics to technological convergence. Chem Soc Rev 2012,41(13),4708-4735 10.1039/c2cs35083a 22618026 Khan N.; Applications of electrospun nanofibers in the biomedical field. Surg J 2012,5(2),63-73 10.21083/surg.v5i2.1471 Fatehi P.; Abbasi M.; Medicinal plants used in wound dressings made of electrospun nanofibers. J Tissue Eng Regen Med 2020,14(11),1527-1548 10.1002/term.3119 32841495 Gholipour K.A.; Bahrami H.S.; Review on electrospun nanofibres scaffold and biomedical applications. Trends Biomater Artif Organs 2010,24(2),93 Li F.; Kang Z.; Huang X.; Zhang G.J.; Fabrication of zirconium carbide nanofibers by electrospinning. Ceram Int 2014,40(7),10137-10141 10.1016/j.ceramint.2014.02.011 Li X.; Kanjwal M.A.; Lin L.; Chronakis I.S.; Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin. Colloids Surf B Biointerfaces 2013,103,182-188 10.1016/j.colsurfb.2012.10.016 23201736 Guarino V.; Cruz-Maya I.; Altobelli R.; Electrospun polycaprolactone nanofibres decorated by drug loaded chitosan nano-reservoirs for antibacterial treatments. Nanotechnology 2017,28(50),505103 10.1088/1361-6528/aa9542 29058684 Ren L.; Ozisik R.; Kotha S.P.; Rapid and efficient fabrication of multilevel structured silica micro-/nanofibers by centrifugal jet spinning. J Colloid Interface Sci 2014,425,136-142 10.1016/j.jcis.2014.03.039 24776675 Elakkiya T.; Malarvizhi G.; Rajiv S.; Natarajan T.S.; Curcumin loaded electrospun Bombyx mori silk nanofibers for drug delivery. Polym Int 2014,63(1),100-105 10.1002/pi.4499 Zhao L.; Chen D.; Yao Q.; Li M.; Studies on the use of recombinant spider silk protein/polyvinyl alcohol electrospinning membrane as wound dressing. Int J Nanomedicine 2017,12,8103-8114 10.2147/IJN.S47256 29138566 Varshosaz J.; Jannesari M.; Morshed M.; Zamani M.; Composite poly(vinyl alcohol)/poly(vinyl acetate) electrospun nanofibrous mats as a novel wound dressing matrix for controlled release of drugs. Int J Nanomedicine 2011,6,993-1003 10.2147/IJN.S17595 21720511 Zhou Y.; Yang D.; Chen X.; Xu Q.; Lu F.; Nie J.; Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Biomacromolecules 2008,9(1),349-354 10.1021/bm7009015 18067266 Saquing C.D.; Tang C.; Monian B.; Alginate–polyethylene oxide blend nanofibers and the role of the carrier polymer in electrospinning. Ind Eng Chem Res 2013,52(26),8692-8704 10.1021/ie302385b Li J.; He A.; Zheng J.; Han C.C.; Gelatin and gelatin−hyaluronic acid nanofibrous membranes produced by electrospinning of their aqueous solutions. Biomacromolecules 2006,7(7),2243-2247 10.1021/bm0603342 Wang X.; Zhao H.; Turng L.S.; Li Q.; Crystalline morphology of electrospun poly(ε-caprolactone) (PCL) nanofibers. Ind Eng Chem Res 2013,52(13),4939-4949 10.1021/ie302185e Bui H.T.; Chung O.H.; Dela Cruz J.; Park J.S.; Fabrication and characterization of electrospun curcumin-loaded polycaprolactone-polyethylene glycol nanofibers for enhanced wound healing. Macromol Res 2014,22(12),1288-1296 10.1007/s13233-014-2179-6 El-Aassar M.R.; El fawal GF, El-Deeb NM, Hassan HS, Mo X. Electrospun polyvinyl alcohol/pluronic f127 blended nanofibers containing titanium dioxide for antibacterial wound dressing. Appl Biochem Biotechnol 2016,178(8),1488-1502 10.1007/s12010-015-1962-y 26686499 Pires L.R.; Guarino V.; Oliveira M.J.; Ibuprofen-loaded poly(trimethylene carbonate-co-ε-caprolactone) electrospun fibres for nerve regeneration. J Tissue Eng Regen Med 2016,10(3),E154-E166 10.1002/term.1792 23950030 Shi Y.; Wei Z.; Zhao H.; Liu T.; Dong A.; Zhang J.; Electrospinning of ibuprofen-loaded composite nanofibers for improving the performances of transdermal patches. J Nanosci Nanotechnol 2013,13(6),3855-3863 10.1166/jnn.2013.7157 23862418 Chaturvedi T.P.; Srivastava R.; Srivastava A.K.; Gupta V.; Verma P.K.; Doxycycline poly e-caprolactone nanofibers in patients with chronic periodontitis - a clinical evaluation. J Clin Diagn Res 2013,7(10),2339-2342 10.7860/JCDR/2013/5858.3519 24298524 Krogstad E.A.; Woodrow K.A.; Manufacturing scale-up of electrospun poly(vinyl alcohol) fibers containing tenofovir for vaginal drug delivery. Int J Pharm 2014,475(1-2),282-291 10.1016/j.ijpharm.2014.08.039 25169075 Huang C.; Soenen S.J.; van Gulck E.; Electrospun cellulose acetate phthalate fibers for semen induced anti-HIV vaginal drug delivery. Biomaterials 2012,33(3),962-969 10.1016/j.biomaterials.2011.10.004 22018388 Rychter M.; Baranowska-Korczyc A.; Milanowski B.; Cilostazol-loaded poly(ε-Caprolactone) electrospun drug delivery system for cardiovascular applications. Pharm Res 2018,35(2),32 10.1007/s11095-017-2314-0 29368067 Jiang Y.N.; Mo H.Y.; Yu D.G.; Electrospun drug-loaded core–sheath PVP/zein nanofibers for biphasic drug release. Int J Pharm 2012,438(1-2),232-239 10.1016/j.ijpharm.2012.08.053 22981688 Kim K.; Luu Y.K.; Chang C.; Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J Control Release 2004,98(1),47-56 10.1016/j.jconrel.2004.04.009 15245888 Zamani M.; Morshed M.; Varshosaz J.; Jannesari M.; Controlled release of metronidazole benzoate from poly ε-caprolactone electrospun nanofibers for periodontal diseases. Eur J Pharm Biopharm 2010,75(2),179-185 10.1016/j.ejpb.2010.02.002 20144711 Park C.G.; Kim E.; Park M.; Park J.H.; Choy Y.B.; Bin A.; A nanofibrous sheet-based system for linear delivery of nifedipine. J Control Release 2011,149(3),250-257 10.1016/j.jconrel.2010.10.023 21035511 Zhang H.; Lou S.; Williams G.R.; A systematic study of captopril-loaded polyester fiber mats prepared by electrospinning. Int J Pharm 2012,439(1-2),100-108 10.1016/j.ijpharm.2012.09.055 23043960 Badawi M.A.; El-Khordagui L.K.; A quality by design approach to optimization of emulsions for electrospinning using factorial and D-optimal designs. Eur J Pharm Sci 2014,58,44-54 10.1016/j.ejps.2014.03.004 24704153 Paneva D.; Manolova N.; Argirova M.; Rashkov I.; Antibacterial electrospun poly(ε-caprolactone)/ascorbyl palmitate nanofibrous materials. Int J Pharm 2011,416(1),346-355 10.1016/j.ijpharm.2011.06.032 21726615 Kenawy E.R.; Bowlin G.L.; Mansfield K.; Release of tetracycline hydrochloride from electrospun poly(ethylene-co-vinylacetate), poly(lactic acid), and a blend. J Control Release 2002,81(1-2),57-64 10.1016/S0168-3659(02)00041-X 11992678 Xie J.; Wang C.H.; Electrospun micro- and nanofibers for sustained delivery of paclitaxel to treat C6 glioma in vitro. Pharm Res 2006,23(8),1817-1826 10.1007/s11095-006-9036-z 16841195 Xu X.; Chen X.; Ma P.; Wang X.; Jing X.; The release behavior of doxorubicin hydrochloride from medicated fibers prepared by emulsion-electrospinning. Eur J Pharm Biopharm 2008,70(1),165-170 10.1016/j.ejpb.2008.03.010 18472256 Vrbata P; Berka P; Stránská D; Doležal P; Musilová M; Čižinská L. Electrospun drug loaded membranes for sublingual administration of sumatriptan and naproxen. Int J Pharm 2013,457(1),168-176 10.1016/j.ijpharm.2013.08.085 24050988 Illangakoon U.E.; Nazir T.; Williams G.R.; Chatterton N.P.; Mebeverine-loaded electrospun nanofibers: Physicochemical characterization and dissolution studies. J Pharm Sci 2014,103(1),283-292 10.1002/jps.23759 24258335 Jafari-Aghdam N.; Adibkia K.; Payab S.; Methylprednisolone acetate–Eudragit ® RS100 electrospuns: Preparation and physicochemical characterization. Artif Cells Nanomed Biotechnol 2016,44(2),497-503 10.3109/21691401.2014.965309 25289448 Canbolat M.F.; Celebioglu A.; Uyar T.; Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun polycaprolactone nanofibers. Colloids Surf B Biointerfaces 2014,115,15-21 10.1016/j.colsurfb.2013.11.021 24316584 Matabola K.P.; Moutloali R.M.; The influence of electrospinning parameters on the morphology and diameter of poly(vinyledene fluoride) nanofibers- effect of sodium chloride. J Mater Sci 2013,48(16),5475-5482 10.1007/s10853-013-7341-6 Bhardwaj N.; Kundu S.C.; Electrospinning: A fascinating fiber fabrication technique. Biotechnol Adv 2010,28(3),325-347 10.1016/j.biotechadv.2010.01.004 20100560 Baumgarten P.K.; Electrostatic spinning of acrylic microfibers. J Colloid Interface Sci 1971,36(1),71-79 10.1016/0021-9797(71)90241-4 Wang T.; Kumar S.; Electrospinning of polyacrylonitrile nanofibers. J Appl Polym Sci 2006,102(2),1023-1029 10.1002/app.24123 Zhao P.; Chen W.; Feng Z.; Electrospun nanofibers for periodontal treatment: A recent progress. Int J Nanomedicine 2022,17,4137-4162 10.2147/IJN.S370340 36118177 Li Z.; Zhang M.; Chitosan-alginate as scaffolding material for cartilage tissue engineering. J Biomed Mater Res A 2005,75A(2),485-493 10.1002/jbm.a.30449 16092113 Liu X.; Lin T.; Gao Y.; Antimicrobial electrospun nanofibers of cellulose acetate and polyester urethane composite for wound dressing. J Biomed Mater Res B Appl Biomater 2012,100(6),1556-1565 10.1002/jbm.b.32724 Chen L.; Bromberg L.; Hatton T.A.; Rutledge G.C.; Electrospun cellulose acetate fibers containing chlorhexidine as a bactericide. Polymer 2008,49(5),1266-1275 10.1016/j.polymer.2008.01.003 Au H.T.; Pham L.N.; Vu T.H.T.; Park J.S.; Fabrication of an antibacterial non-woven mat of a poly(lactic acid)/chitosan blend by electrospinning. Macromol Res 2012,20(1),51-58 10.1007/s13233-012-0010-9 Zhang L.; Aboagye A.; Kelkar A.; Lai C.; Fong H.; A review: carbon nanofibers from electrospun polyacrylonitrile and their applications. J Mater Sci 2014,49(2),463-480 10.1007/s10853-013-7705-y Zhang Y.Z.; Wang X.; Feng Y.; Li J.; Lim C.T.; Ramakrishna S.; Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly(ε-caprolactone) nanofibers for sustained release. Biomacromolecules 2006,7(4),1049-1057 10.1021/bm050743i 16602720 Zhang Y.Z.; Feng Y.; Huang Z-M.; Ramakrishna S.; Lim C.T.; Fabrication of porous electrospun nanofibres. Nanotechnology 2006,17(3),901-908 10.1088/0957-4484/17/3/047 Chinthaka Silva G.W.; Kercher A.A.; Hunn J.D.; Martin R.C.; Jellison G.E.; Meyer H.M.; Characterization of zirconium carbides using electron microscopy, optical anisotropy, Auger depth profiles, X-ray diffraction, and electron density calculated by charge flipping method. J Solid State Chem 2012,194,91-99 10.1016/j.jssc.2012.04.047 Katoh Y.; Vasudevamurthy G.; Nozawa T.; Snead L.L.; Properties of zirconium carbide for nuclear fuel applications. J Nucl Mater 2013,441(1-3),718-742 10.1016/j.jnucmat.2013.05.037 Preiss H.; Schierhorn E.; Brzezinka K.W.; Synthesis of polymeric titanium and zirconium precursors and preparation of carbide fibres and films. J Mater Sci 1998,33(19),4697-4706 10.1023/A:1004428818457 Nam Y.S.; Cui X.M.; Jeong L.; Lee J.Y.; Park W.H.; Fabrication and characterization of zirconium carbide (ZrC) nanofibers with thermal storage property. Thin Solid Films 2009,517(24),6531-6538 10.1016/j.tsf.2009.04.021 Thangapazham R.L.; Sharad S.; Maheshwari R.K.; Phytochemicals in wound healing. Adv Wound Care 2016,5(5),230-241 10.1089/wound.2013.0505 27134766 Grassian V.H.; O’Shaughnessy P.T.; Adamcakova-Dodd A.; Pettibone J.M.; Thorne P.S.; Inhalation exposure study of titanium dioxide nanoparticles with a primary particle size of 2 to 5 nm. Environ Health Perspect 2007,115(3),397-402 10.1289/ehp.9469 17431489 Ulubayram K.; Nur Cakar A.; Korkusuz P.; Ertan C.; Hasirci N.; EGF containing gelatin-based wound dressings. Biomaterials 2001,22(11),1345-1356 10.1016/S0142-9612(00)00287-8 11336307 Kurakula M; N NR. Prospection of recent chitosan biomedical trends: Evidence from patent analysis (2009–2020). Int J Biol Macromol 2020,165(Pt B),1924-38 10.1016/j.ijbiomac.2020.10.043 33068625 Islam M.M.; Naveen N.R.; Anitha P.; The race to replace PDE5i: Recent advances and interventions to treat or manage erectile dysfunction: Evidence from patent landscape (2016–2021). J Clin Med 2022,11(11),3140 10.3390/jcm11113140 35683526 Rao G.S.N.K.; Gowthami B.; Naveen N.R.; Samudrala P.K.; An updated review on potential therapeutic drug candidates, vaccines and an insight on patents filed for COVID-19. Current Research in Pharmacology and Drug Discovery 2021,2,100063 10.1016/j.crphar.2021.100063 34870158 Gowthami B.; Krishna S.V.G.; Rao D.S.; Application of coating technology to chronotherapeutic drug delivery systems: Recent publications and patents. CRPHAR 2021,2,100015 10.1016/j.crphar.2021.100015 34909650 Fonseca L.M.; Cruxen C.E.S.; Bruni G.P.; Development of antimicrobial and antioxidant electrospun soluble potato starch nanofibers loaded with carvacrol. Int J Biol Macromol 2019,139,1182-1190 10.1016/j.ijbiomac.2019.08.096 31415859 Raeisi M.; Mohammadi M.A.; Bagheri V.; Fabrication of electrospun nanofibres of soy protein isolate/polyvinyl alcohol embedded with cinnamon zeylanicum and zataria multiflora essential oils and their antibacterial effect. Biointerface Res Appl Chem 2023,13 10.33263/BRIAC135.486 Hermosilla J.; Pastene-Navarrete E.; Acevedo F.; Electrospun fibers loaded with natural bioactive compounds as a biomedical system for skin burn treatment. a review. Pharmaceutics 2021,13(12),2054 10.3390/pharmaceutics13122054 34959336 Hinderer S.; Schesny M.; Bayrak A.; Engineering of fibrillar decorin matrices for a tissue-engineered trachea. Biomaterials 2012,33(21),5259-5266 10.1016/j.biomaterials.2012.03.075 22521489 Kador K.E.; Montero R.B.; Venugopalan P.; Tissue engineering the retinal ganglion cell nerve fiber layer. Biomaterials 2013,34(17),4242-4250 10.1016/j.biomaterials.2013.02.027 23489919 Gustafsson Y.; Haag J.; Jungebluth P.; Viability and proliferation of rat MSCs on adhesion protein-modified PET and PU scaffolds. Biomaterials 2012,33(32),8094-8103 10.1016/j.biomaterials.2012.07.060 22901964 Vaquette C.; Fan W.; Xiao Y.; Hamlet S.; Hutmacher D.W.; Ivanovski S.; A biphasic scaffold design combined with cell sheet technology for simultaneous regeneration of alveolar bone/periodontal ligament complex. Biomaterials 2012,33(22),5560-5573 10.1016/j.biomaterials.2012.04.038 22575832 Xi Y.; Ge J.; Guo Y.; Lei B.; Ma P.X.; Biomimetic elastomeric polypeptide-based nanofibrous matrix for overcoming multidrug-resistant bacteria and enhancing full-thickness wound healing/skin regeneration. ACS Nano 2018,12(11),10772-10784 10.1021/acsnano.8b01152 30481960 Luo B.; Tian L.; Chen N.; Ramakrishna S.; Thakor N.; Yang I.H.; Electrospun nanofibers facilitate better alignment, differentiation, and long-term culture in an in vitro model of the neuromuscular junction (NMJ). Biomater Sci 2018,6(12),3262-3272 10.1039/C8BM00720A 30402630 Wang Y.; Cui W.; Chou J.; Wen S.; Sun Y.; Zhang H.; Electrospun nanosilicates-based organic/inorganic nanofibers for potential bone tissue engineering. Colloids Surf B Biointerfaces 2018,172,90-97 10.1016/j.colsurfb.2018.08.032 30142529 Jing X.; Mi H.Y.; Wang X.C.; Peng X.F.; Turng L.S.; Shish-kebab-structured poly(ε-caprolactone) nanofibers hierarchically decorated with chitosan-poly(ε-caprolactone) copolymers for bone tissue engineering. ACS Appl Mater Interfaces 2015,7(12),6955-6965 10.1021/acsami.5b00900 25761418 Mirzaei S.; Karkhaneh A.; Soleimani M.; Ardeshirylajimi A.; Seyyed Z.H.; Hanaee-Ahvaz H.; Enhanced chondrogenic differentiation of stem cells using an optimized electrospun nanofibrous PLLA/PEG scaffolds loaded with glucosamine. J Biomed Mater Res A 2017,105(9),2461-2474 10.1002/jbm.a.36104 28481047 Piai J.F.; da Silva M.A.; Martins A.; Chondroitin sulfate immobilization at the surface of electrospun nanofiber meshes for cartilage tissue regeneration approaches. Appl Surf Sci 2017,403,112-125 10.1016/j.apsusc.2016.12.135

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