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Review Article

钠-葡萄糖协同转运蛋白2抑制剂与病理性心肌肥厚

卷 24, 期 13, 2023

发表于: 08 September, 2023

页: [1009 - 1022] 页: 14

弟呕挨: 10.2174/1389450124666230907115831

open access plus

摘要

钠-葡萄糖协同转运蛋白2（SGLT2）抑制剂是一种新型口服降糖药物，通过阻断近端肾小管对葡萄糖的重吸收，从而促进葡萄糖从尿液中排出，从而发挥降血糖作用。它们的降血糖作用不依赖于胰岛素。越来越多的数据表明，SGLT2抑制剂可改善2型糖尿病患者的心血管预后。先前的研究已经证明，SGLT2抑制剂可以减轻伴有或不伴有糖尿病的病理性心肌肥大，但其确切机制仍有待阐明。为了阐明SGLT2抑制剂与病理性心肌肥大的关系，以期为未来的治疗提供参考，本研究综述了SGLT2抑制物减轻病理性心肌肥厚的可能机制。我们特别关注炎症、氧化应激、心肌纤维化、线粒体功能等方面的机制。

关键词: 钠-葡萄糖协同转运蛋白2抑制剂、心肌肥大、心肌纤维化、炎症、心外膜脂肪组织、Na+/H+交换器、胰岛素抵抗、自噬。

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图形摘要

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