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Review Article

生物功能介孔二氧化硅纳米粒子作为癌症纳米结构载体的研究进展

卷 24, 期 12, 2023

发表于: 25 August, 2023

页: [934 - 944] 页: 11

弟呕挨: 10.2174/1389450124666230817103122

价格: $65

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摘要

背景：癌症在世界范围内是一种危及生命的疾病，但目前尚未开发出合适的治疗方法。许多疗法可用于治疗癌症疾病，如化疗、手术、激素治疗和免疫疗法。化疗通常依赖于有害的、剧毒的铂基化合物的组合。此外，化疗药物和细胞毒性对大多数细胞的分布也很差，这会导致对其他健康细胞的损伤，也有产生耐药性的机会。 目的：本研究的主要目的是开发介孔二氧化硅纳米粒子。介孔二氧化硅纳米颗粒被认为是具有高载药能力和显著功能化表面积的载体，用于靶向药物递送。介孔二氧化硅纳米颗粒具有形状、粒径、孔体积、较高的表面积和表面改性的可能性。因此产生了热稳定性和化学稳定性的纳米材料。对于靶向药物递送，MSN与多种配体偶联，包括单克隆抗体、透明质酸、转铁蛋白、叶酸等，这些配体对恶性细胞表面过表达的受体具有特殊的亲和力，因此使用这种纳米载体可以降低正常细胞的剂量相关毒性。 方法：综述了合成中孔二氧化硅纳米颗粒的不同方法。采用溶胶-凝胶法和改良的stobber法合成了该纳米颗粒。 结果：成功合成了粒径在50-200nm左右的介孔二氧化硅纳米粒子，载药效率约为71%。 结论：介孔二氧化硅纳米粒子是细胞内和靶向药物递送系统的良好载体。

关键词: 介孔二氧化硅，纳米颗粒吸收机制，合成方法，应用，表征，毒性，安全性。

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